1,1-二甲氧基己烷-2-酮 | 6344-10-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,1-二甲氧基己烷-2-酮
• 英文名称: 1,1-Dimethoxy-2-hexanone
• 英文别名: 1,1-dimethoxy-hexan-2-one；1,1-Dimethoxy-hexan-2-on；1,1-Dimethoxyhexan-2-one
• CAS: 6344-10-1
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: KNZBHMSRULVCIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-二甲氧基己烷-2-酮 在 对甲苯磺酸 水 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 生成 2-氧代己醛
  参考文献：
  名称：

  Selenium-mediated conversion of alkynes into .alpha.-dicarbonyl compounds

  摘要：

  The reaction of terminal and internal alkynes with diphenyl diselenide and ammonium peroxydisulfate in methanol proceeds smoothly to give alpha-keto acetals and alpha-keto ketals, respectively. This one-pot procedure is suggested to proceed through the initial formation of phenylselenenyl sulfate, a strong electrophilic reagent which effects the methoxyselenenylation of the alkynes. The addition products thus formed suffer methoxydeselenenylation giving the observed products and regenerating the phenylselenenylating agent. In some cases the reaction can be carried out using only catalytic amounts of diphenyl diselenide. The same reaction carried out in the presence of water or of ethylene glycol gives the unprotected or the diprotected alpha-dicarbonyl compounds, respectively.

  DOI：

  10.1021/jo00014a038
• 作为产物：
  描述：

  2-己酮 在 苯乙烯 、 盐酸 、 ammonium persulfate 、 二苯基二硒醚 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 1,1-二甲氧基己烷-2-酮
  参考文献：
  名称：

  Selenium-catalyzed conversion of methyl ketones into .alpha.-keto acetals

  摘要：

  DOI：

  10.1021/jo00302a012

文献信息

• 1-Substituted-1-oxo-prostane-derivatives of the E, A and F series
  申请人：American Cyanamid Company

  公开号：US04297516A1

  公开（公告）日：1981-10-27

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: ##STR1## wherein R is C.sub.1 to C.sub.6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR.sub.16, SR.sub.16, F, or Cl, and R.sub.16 is C.sub.1 to C.sub.6 alkyl.

  本发明公开的药物活性前列腺素衍生物属于E、F或A系列，在α链的末端亚甲基碳上有一个取代基，该取代基从以下组中选择：##STR1## 其中R是C.sub.1至C.sub.6烷基，和苯基或苯基，苯基上带有1个或多个取代基，该取代基从以下组中选择：C.sub.1-C.sub.4烷基，OR.sub.16，SR.sub.16，F或Cl，R.sub.16是C.sub.1至C.sub.6烷基。
• 1-Hydroxymethyl-1-oxo-prostane-derivatives of the E, A and F-series
  申请人：American Cyanamid Company

  公开号：US04254036A1

  公开（公告）日：1981-03-03

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 -alkylamino, C.sub.1 -C.sub.4 alkoxy, and phenyl or phenyl substituted with one or more substituents from the group consisting of C.sub.1 -C.sub.4, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物：##STR1##其中R是烷基基团，R.sub.15是C.sub.1 -C.sub.4烷基，二C.sub.1 -C.sub.4-烷基氨基，C.sub.1 -C.sub.4烷氧基，苯基或苯基，其上取代基来自C.sub.1 -C.sub.4，OR，SR，F或Cl的组成，其中R如前所定义。
• 15-Deoxy-16-hydroxy-16-formyo or dimethoxy-methyl-prostane derivatives
  申请人：American Cyanamid Company

  公开号：US04230879A1

  公开（公告）日：1980-10-28

  The invention disclosed herein relates to pharmacologically active prostaglandins of the E and F series in which C-16 is substituted with hydroxyl and formyl or dimethoxymethyl as well as the pharmaceutically acceptable, non-toxic lower alkyl esters and salts thereof, and to the intermediates and processes for producing such compounds.

  本发明涉及具有C-16位被羟基、甲酰基或二甲氧甲基取代的E和F系列药理活性前列腺素，以及其药用可接受的、无毒的低烷基酯和盐，以及用于生产这些化合物的中间体和工艺。
• 1-Hydroxymethyl-1-oxo-prostane derivatives of the E, A and F series
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0015056A1

  公开（公告）日：1980-09-03

  The invention disclosed relates to pharmacologically active prostaglandin derivates of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: wherein R is an alkyl group and R13 is C1-C4 alkyl, di-C,-C. -alkylamino, C1-C4 alkoxy, and phenyl or phenyl substituted with one or more substituents from the group consisting of C1-C4, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有药理活性的 E、F 或 A 系列前列腺素衍生物，其 α 链的末端亚甲基碳上具有选自以下组别的取代基： 其中 R 是烷基，R13 是 C1-C4 烷基、二-C,-C.-烷基氨基、C1-C4 烷氧基和苯基或被一个或多个取代基取代的苯基，取代基可从 C1-C4、OR、SR、F 或 Cl 组成的组中选出，其中 R 如前定义。
• Studies in Mixed Ester Condensations. IV. Acylations with Methyl Dimethoxyacetate¹
  作者：E. Earl Royals、A. G. Robinson

  DOI：10.1021/ja01597a083

  日期：1956.8