1,1’-(苯基亚氨基)双-2-丙醇 | 3077-13-2

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,1’-(苯基亚氨基)双-2-丙醇
• 中文别名: N,N-双(2-羟丙基)苯胺；N,N-二(2-羟丙基)苯胺；1,1'-(苯基亚氨基)双-2-丙醇
• 英文名称: N-phenyl-bis-(2-hydroxypropyl)amine
• 英文别名: 3,3'-(phenylazanediyl)bis(propan-2-ol)；N,N-bis(2-hydroxypropyl)aniline；N-(2-hydroxypropyl)aniline；N,N-bis(2-hydroxypropyl)-aniline；N,N-bis-(2-hydroxy-propyl)-aniline；N,N-Bis-(2-hydroxy-propyl)-anilin；1-[N-(2-hydroxypropyl)anilino]propan-2-ol
• CAS: 3077-13-2
• 化学式: C₁₂H₁₉NO₂
• mdl: MFCD00059141
• 分子量: 209.288
• InChiKey: FKOMNQCOHKHUCP-UHFFFAOYSA-N

物化性质

• 沸点：
  184-185 °C(Press: 10 Torr)
• 密度：
  1.0694 g/cm3(Temp: 23 °C)
• 物理描述：
  Liquid
• 稳定性/保质期：
  遵照规定使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090
• 储存条件：
  存放于阴凉干燥处。

SDS

N,N-Bis(2-hydroxypropyl)aniline (DL- and meso- Revision number: 6
mixture)
SAFETY DATA SHEET

---

Section 1. IDENTIFICATION
Product name: N,N-Bis(2-hydroxypropyl)aniline (DL- and meso- mixture)

Revision number: 6

---

Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
Not classified
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols None
Signal word No signal word
Hazard statements None
Precautionary statements: None

---

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance
Substance/mixture:
Components: N,N-Bis(2-hydroxypropyl)aniline (DL- and meso- mixture)
>85.0%(GC)
Percent:
CAS Number: 3077-13-2
Anilinodi-2-propanol (DL- and meso- mixture) , 1,1'-(Phenylimino)di-2-propanol (DL-
Synonyms:
and meso- mixture)
Chemical Formula: C12H19NO2

---

Section 4. FIRST AID MEASURES
Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Inhalation:
Get medical advice/attention if you feel unwell.
Remove/Take off immediately all contaminated clothing. Rinse skin with
Skin contact:
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Rinse cautiously with water for several minutes. Remove contact lenses, if present
Eye contact:
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

---

Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
from the chemical:
N,N-Bis(2-hydroxypropyl)aniline (DL- and
meso- mixture)

---

Section 5. FIRE-FIGHTING MEASURES
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

---

Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in a suitable absorbent (e.g. rag, dry sand, earth, saw-dust).
containment and cleaning In case of large amount of spillage, contain a spill by bunding. Adhered or collected
up: material should be promptly disposed of, in accordance with appropriate laws and
regulations.

---

Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Wash hands and face thoroughly after
handling.
Use a ventilation, local exhaust if vapour or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store under inert gas.
Store away from incompatible materials such as oxidizing agents.
Air-sensitive
Packaging material: Comply with laws.

---

Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Install a closed system or local exhaust as possible so that workers should not be
Engineering controls:
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Protective gloves.
Hand protection:
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: Clear
Colorless - Slightly pale yellow
Colour:
Odour: No data available
pH: No data available
Melting point/freezing point:No data available
No data available
Boiling point/range:
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: No data available
Solubility(ies):
N,N-Bis(2-hydroxypropyl)aniline (DL- and
meso- mixture)

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
[Water] No data available
[Other solvents] No data available

---

Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)
products:

---

Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
No data available
IARC =
NTP = No data available
Reproductive toxicity: No data available

---

Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
No data available
Crustacea:
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

---

Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

---

Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed

---

Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
N,N-Bis(2-hydroxypropyl)aniline (DL- and
meso- mixture)

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1,1’-(苯基亚氨基)双-2-丙醇 在 硫酸 作用下， 生成 2,6-dimethyl-4-phenylmorpholine
  参考文献：
  名称：

  Kuroki et al., Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1956, vol. 59, p. 909,910

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯丙酸甲酯 、 苯胺 在 lithium aluminium tetrahydride 作用下， 生成 1,1’-(苯基亚氨基)双-2-丙醇
  参考文献：
  名称：

  Nishiyama, Tomihiro; Iwasaki, Yoshiaki; Nishikawa, Takeshi, Journal of Heterocyclic Chemistry, 1991, vol. 28, # 5, p. 1369 - 1372

  摘要：

  DOI：

文献信息

• Zinc Tetrafluoroborate Hydrate as a Mild Catalyst for Epoxide Ring Opening with Amines: Scope and Limitations of Metal Tetrafluoroborates and Applications in the Synthesis of Antihypertensive Drugs (<i>RS</i>)/(<i>R</i>)/(<i>S</i>)-Metoprolols
  作者：Brahmam Pujala、Shivani Rana、Asit K. Chakraborti

  DOI：10.1021/jo201473f

  日期：2011.11.4

  reaction at the benzylic carbon of the epoxide ring. A reversal of regioselectivity (91:1–69:31) in favor of the reaction at the terminal carbon of the epoxide ring was observed for reaction with morpholine. The regioselectivity was dependent on the electronic and steric factors of the epoxide and the pKa of the amine and independent of amine nucleophilicity. The role of the metal tetrafluoroborates is

  已经研究了金属四氟硼酸盐与胺进行环氧化物开环反应的范围和局限性，并且发现Zn（BF 4）2 · x H 2 O是一种温和而有效的催化剂，在无溶剂条件下于200 ℃提供高收率。 rt具有出色的化学，区域和立体选择性。催化效率依次为Zn（BF 4）2 · x H 2 O≫ Cu（BF 4）2 · x H 2 O> Co（BF 4）2 ·6H 2 O≫ Fe（BF 4）2 ·6H2 O> LiBF 4与环己烯氧化物和Zn（BF 4）2 · x H 2 O≫ Co（BF 4）2 ·6H 2 O≫ Fe（BF 4）2 ·6H 2 O> Cu（BF 4）反应2 · x H 2 O，用于氧化二苯乙烯，但AgBF 4是无效的。对于苯乙烯氧化物与苯胺的反应，四氟硼酸金属具有相当的区域选择性（1：99–7：93），并且在环的苄基碳上具有优先反应。与吗啉反应时，观察到区域选择性的逆转（91：1–69：31），有
• Antibacterial water-soluble cutting fluids resistant to yeast-like fungi
  申请人：YUSHIRO CHEMICAL INDUSTRY CO. LTD.

  公开号：EP0388320A1

  公开（公告）日：1990-09-19

  A bactericide is added to conventional water-soluble cutting fluids to suppress deterioration by micro­organisms. Such fluids are however accompanied by the drawbacks that the bactericide has a narrow antibacterial spectrum and moreover its effects last a short time. It is the object of the present invention to offers water-­soluble cutting fluids which remain resistant to a wide variety of microorganisms for a long time. The present invention therefore offers water-soluble cutting fluids to which has been added a specific amine selected from amines known to date.

  将细菌杀灭剂添加到传统的水溶性切削液中，以抑制微生物的腐败。然而，这种液体伴随着细菌杀灭剂的缺点，即细菌杀灭剂的抗菌谱较窄，而且其效果持续时间较短。本发明的目的是提供一种长时间保持对各种微生物具有抗性的水溶性切削液。因此，本发明提供了一种水溶性切削液，其中添加了一种特定的胺，该胺是从迄今为止已知的胺中选择的。
• Fe(Cp)2BF4: An Efficient Lewis Acid Catalyst for the Aminolysis of Epoxides
  作者：Surendra Singh、Geeta Yadav、ManMohan Chauhan

  DOI：10.1055/s-0033-1340498

  日期：——

  yields at 60 °C under solvent-free conditions. Ferrocenium tetrafluoroborate [Fe(Cp)2BF4] is an efficient Lewis acid catalyst for the aminolysis of aromatic, aliphatic, and cyclic epoxides using aniline and substituted anilines as the nucleophile to provide regioselective β-amino alcohols in 61–97% yields under solvent-free conditions at room temperature. The ring opening of cyclohexene oxide with aliphatic

  摘要 四氟硼酸二铁硼[Fe（Cp）2 BF 4 ]是一种有效的路易斯酸催化剂，可使用苯胺和取代的苯胺作为亲核试剂对芳族，脂族和环状环氧化物进行氨解，在61-97％的产率下可提供区域选择性的β-氨基醇室温下无​​溶剂条件。在无溶剂条件下，于60°C时，环己烯氧化物与脂肪族胺的开环反应生成2-氨基环己醇，产率为33–98％。 四氟硼酸二铁硼[Fe（Cp）2 BF 4 ]是一种有效的路易斯酸催化剂，可使用苯胺和取代的苯胺作为亲核试剂对芳族，脂族和环状环氧化物进行氨解，在61-97％的产率下可提供区域选择性的β-氨基醇室温下无​​溶剂条件。在无溶剂条件下，于60°C时，环己烯氧化物与脂肪族胺的开环反应生成2-氨基环己醇，产率为33–98％。
• MULTIFUNCTIONAL (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD.

  公开号：US20170204044A1

  公开（公告）日：2017-07-20

  [Problem] The purpose of the present invention is to obtain a multifunctional (meth)acrylate with good yield by an ester exchange reaction of a polyhydric alcohol such as pentaerythritol or dipentaerythritol with a monofunctional (meth)acrylate. [Solution] A multifunctional (meth)acrylate manufacturing method characterized in that when manufacturing a multifunctional (meth)acrylate by an ester exchange reaction of a polyhydric alcohol with a monofunctional (meth)acrylate, catalyst (A) and catalyst (B) are used together. Catalyst (A): One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure or salts or complexes thereof, amidines or salts or complexes thereof, and compounds with a pyridine ring or salts or complexes thereof. Catalyst (B): One or more kinds of compounds selected from a group consisting of zinc-containing compounds.

  [问题] 本发明的目的是通过多元醇（如戊三醇或二戊三醇）与单官能基（甲基）丙烯酸酯的酯交换反应，获得产率高的多功能（甲基）丙烯酸酯。[解决方案] 一种多功能（甲基）丙烯酸酯制备方法，其特征在于，在通过多元醇与单官能基（甲基）丙烯酸酯的酯交换反应制备多功能（甲基）丙烯酸酯时，同时使用催化剂（A）和催化剂（B）。催化剂（A）：选自具有氮杂双环结构的环三胺或其盐或络合物、酰胺或其盐或络合物以及吡啶环或其盐或络合物组成的群中的一种或多种化合物。催化剂（B）：选自含锌化合物组成的群中的一种或多种化合物。
• METHOD FOR PRODUCING (METH)ACRYLATE
  申请人：TOAGOSEI CO., LTD.

  公开号：US20180105483A1

  公开（公告）日：2018-04-19

  A method for producing a (meth) acrylate comprises transesterification reaction of an alcohol and a monofunctional (meth) acrylate with catalysts in combination being cyclic tertiary amines having an azabicyclo structure and compounds containing zinc, separating a solid that contains the catalysts from a reaction product containing a (meth) acrylate, and producing a (meth) acrylate by transesterification reaction of an alcohol and a monofunctional (meth) acrylate, while using the recovered solid catalyst.

  生产（甲基）丙烯酸酯的方法包括使用具有氮杂双环结构的环状三级胺和含锌化合物作为催化剂，将醇和单官能团（甲基）丙烯酸酯进行酯交换反应，从含有催化剂的固体中分离出含有（甲基）丙烯酸酯的反应产物，然后通过将醇和单官能团（甲基）丙烯酸酯进行酯交换反应，并使用回收的固体催化剂来生产（甲基）丙烯酸酯。