1,2,3,4-噻三唑-5-胺 | 6630-99-5

• 物质功能分类: 医药中间体 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1,2,3,4-噻三唑-5-胺
• 中文别名: 1,2,3,4-硫噻唑-5-胺； 5-氨基-1,2,3,4-噻三唑
• 英文名称: 1,2,3,4-thiatriazole-5-amine
• 英文别名: 5-Amino-1,2,3,4-thiatriazol；5-amino-1,2,3,4-thiatriazole；1,2,3,4-Thiatriazol-5-amine；thiatriazol-5-amine
• CAS: 6630-99-5
• 化学式: CH₂N₄S
• mdl: MFCD00159813
• 分子量: 102.12
• InChiKey: NFSGFYBDMKUQJA-UHFFFAOYSA-N

物化性质

• 熔点：
  129°C
• 沸点：
  -91.3°C
• 密度：
  1.562 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933990090
• 包装等级：
  III
• 危险类别：
  4.1
• 危险性防范说明：
  P210,P240,P241,P280,P370+P378
• 危险品运输编号：
  1325
• 危险性描述：
  H228
• 储存条件：
  室温且干燥环境中保存。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 1,2,3,4-Thiatriazol-5-amine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 1,2,3,4-Thiatriazol-5-amine
CAS number: 6630-99-5

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: CH2N4S
Molecular weight: 102.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

类别：爆炸物品

• 毒性分级：高毒
• 急性毒性：
  • 腹腔注射（大鼠）LD50：200毫克/公斤
  • 腹腔注射（小鼠）LD50：6500毫克/公斤

爆炸物危险特性：

• 非常不稳定，自燃点为130℃

可燃性危险特性：

• 可燃；高温时产生有毒的氮氧化物和硫氧化物烟雾

储运特性：

• 库房需保持通风、低温及干燥

灭火剂：

• 干粉、泡沫、砂土、二氧化碳，以及雾状水

反应信息

• 作为反应物：
  描述：

  1,2,3,4-噻三唑-5-胺 生成 1-Methyl-3-(2-methyl-3-oxo-2,3-dihydro-[1,2,4]thiadiazol-5-yl)-urea
  参考文献：
  名称：

  GRAUBAUM, HEINZ;SEEBOTH, HELMUTH;BIGALKE, KRISTINA

  摘要：

  DOI：
• 作为产物：
  描述：

  氨基硫脲 在 盐酸 、 sodium nitrite 作用下， 生成 1,2,3,4-噻三唑-5-胺
  参考文献：
  名称：

  Lieber et al., Journal of Organic Chemistry, 1957, vol. 22, p. 440,442

  摘要：

  DOI：

文献信息

• A Model for Using Novel Nursing Interventions to Meet the Challenges of Community Health Needs
  作者：Julie A. Koehler、Jennifer Cha、Carol E. Smith

  DOI：10.1177/1084822302014002007

  日期：2002.2

  The aging population growth, shortened hospital stays, reduction in home care services reimbursement, and the looming nursing shortage will all drastically increase community health care needs and caregiving challenges. Unique and traditional methods of care delivery provided via innovative interventions can be used to address these needs. Many research-based nursing interventions can be administered at a distance (e.g., video, telehealth, and even robotic “nurses”) or without the nurse being present through volunteers or delegation, thus increasing communitybased care. A model categorizing and guiding use of these nursing interventions is described herein.

  人口老龄化增长、住院时间缩短、家庭护理服务费用减少以及迫在眉睫的护理人员短缺将大幅增加社区医疗需求和护理挑战。通过创新干预提供独特和传统的护理方法可以解决这些需求。许多基于研究的护理干预可以远程实施（例如视频、远程医疗，甚至是机器人“护士”），或者在护士不在场的情况下通过志愿者或委派进行，从而增加社区护理。本文描述了一个对这些护理干预进行分类和指导使用的模型。
• Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXII: Bisoxazol-, Bisimidazol-, Bisthiazol- and Oligo-1,2,4-thiadiazolimines
  作者：Klaus Rehse、Antje Martens

  DOI：10.1002/ardp.19933260706

  日期：——

  for their antiplatelet and anticoagulant activities. The most potent compound was the tris‐thiadiazole derivative 18m which inhibited the aggregation of platelets induced by collagen at a concentration of 10 μmol/L by 50 percent (Born‐test). No anticoagulant effects (Quick‐test) were observed up to 400 μmol/L. In the thiazolamine series combined antiplatelet and anticoagulant activities were seen.

  一个介离子4,4'-丙烯-双-恶唑-5-亚胺（5），两个2,2'-间-亚苯基-双-咪唑-4-亚胺（9a，b），五个4,4'-苯-双-（和三）-噻唑-2-胺（13a、b、14a-c）和 14 3,3'-苯-双-（和三）-1,2,4-噻二唑亚胺（18a-o）合成并测定了它们的抗血小板和抗凝活性。最有效的化合物是三噻二唑衍生物 18m，它在 10 μmol/L 的浓度下抑制了 50% 的胶原蛋白诱导的血小板聚集（Born 试验）。在高达 400 μmol/L 时未观察到抗凝作用（快速测试）。在噻唑胺系列中可以看到抗血小板和抗凝活性的结合。
• 5-Amino-1,2,3,4-thiatriazole: Its acylation with chloroformates and chlorothioformates as a route to 1,2,4-thiadiazoles and 1,6,6a,?4-trithia-3,4-diazapentalenes
  作者：Heinz Graubaum、Helmuth Seeboth、Peter Zalupsky

  DOI：10.1007/bf00808771

  日期：1989.11
• Goerdeler et al., Chemische Berichte, 1954, vol. 87, p. 68,74
  作者：Goerdeler et al.

  DOI：——

  日期：——
• Jensen; Pedersen, Advances in Heterocyclic Chemistry, 1964, vol. 3, p. 263,281
  作者：Jensen、Pedersen

  DOI：——

  日期：——