(10Z,16E)-11,19,21-trihydroxy-22-[5-[5-(1-hydroxyethyl)-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (10Z,16E)-11,19,21-trihydroxy-22-[5-[5-(1-hydroxyethyl)-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
• 化学式: C₄₁H₇₂O₉
• 分子量: 709.0
• InChiKey: PGHMRUGBZOYCAA-LUEAQUJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  50
• 可旋转键数：
  22
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  154
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Method for polypeptide transfer into cells
  申请人：Lophius Biosciences GmbH

  公开号：EP2239569A1

  公开（公告）日：2010-10-13

  The present invention relates to a method for polypeptide transfer into cells. The present invention further relates to the detection of polypeptide-specific immune cells and the priming, expansion and reactivation of polypeptide-specific T cells. Moreover the present invention relates to polypeptides of the methods of the present invention in combination with urea and their use for research, diagnosis or treatment and prevention of diseases in animals and humans.

  本发明涉及一种将多肽转移到细胞中的方法。本发明还涉及多肽特异性免疫细胞的检测以及多肽特异性 T 细胞的激发、扩增和再激活。此外，本发明还涉及本发明方法中与尿素结合的多肽及其在研究、诊断或治疗以及预防动物和人类疾病方面的用途。
• Method and kit for detecting and quantifying intracellular histamine and histamine release
  申请人：Universiteit Antwerpen

  公开号：EP2506011A2

  公开（公告）日：2012-10-03

  The present invention provides methods and kits for detecting and quantifying intracellular histamine and histamine release in individual mast cells and/or basophils by cytometry based on an enzyme-affinity method wherein histaminase diamine oxidase (DAO) is coupled to a laser-excitable fluorochrome.

  本发明提供了通过基于酶亲和法的细胞计数法检测和量化单个肥大细胞和/或嗜碱性粒细胞中的细胞内组胺和组胺释放的方法和试剂盒，其中组胺酶二胺氧化酶（DAO）与可激光激发的荧光色素耦合。
• Compounds which inhibit neuronal exocytosis
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：US10035820B2

  公开（公告）日：2018-07-31

  Compounds of general formula (I): R1—Wn—Xm-AA1-AA2-AA3-AA4-AA5-AA6-AA7-Yp—Zq—R2, their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.

  通式(I)化合物：R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-AA7-Yp-Zq-R2、它们的立体异构体、它们的混合物和/或它们的化妆品或药学上可接受的盐、含有它们的制备工艺、化妆品或药物组合物以及它们在医学上的用途，特别是在治疗和/或预防疼痛、炎症、瘙痒、神经系统疾病、强迫症和/或神经精神疾病和/或紊乱，以及在治疗和/或护理由神经元外分泌介导的皮肤、毛发和/或粘膜的过程中的用途。
• Compositions that include anthocyanidins and methods of use
  申请人：Burgos Rafael

  公开号：US10786522B2

  公开（公告）日：2020-09-29

  The compositions described herein and featured in the present invention include those that comprise anthocyanidin combinations rich in delphinidins, including delphinidins such as the ones found in berries. The compositions can optionally include either compositions that comprise andrographolides, such as the ones found in a plant of the genus Andrographis, or compositions that comprise combinations of myrtillin, quercetin, or caffeoyl quinic derivatives and proanthocyanidins, such as the ones found in the herba of a plant of the genus Vaccinium.

  本文所述和本发明中的组合物包括富含鹅掌楸素的花青素组合物，包括鹅掌楸素，如浆果中的鹅掌楸素。这些组合物可以选择包括穿心莲内酯的组合物，如穿心莲属植物中的穿心莲内酯；或者包括桃金娘素、槲皮素或咖啡酰醌衍生物和原花青素组合的组合物，如越橘属植物中的越橘内酯。
• Genetically modified non-human animal with human or chimeric CD27
  申请人：Biocytogen Pharmaceuticals (Beijing) Co., Ltd.

  公开号：US10980222B2

  公开（公告）日：2021-04-20

  The present disclosure relates to genetically modified non-human animals (e.g., genetically-modified mice) that express a human or chimeric (e.g., humanized) CD27. The present disclosure also relates to methods of generating the genetically-modified animals (e.g., genetically modified mice), and methods of using the genetically modified non-human animals (e.g., genetically modified mice) described herein.

  本公开涉及表达人或嵌合（如人源化）CD27的转基因非人类动物（如转基因小鼠）。本公开还涉及产生本文所述转基因动物（如转基因小鼠）的方法，以及使用本文所述转基因非人类动物（如转基因小鼠）的方法。