1,5-脱水山梨糖醇-6-磷酸酯 | 17659-59-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,5-脱水山梨糖醇-6-磷酸酯
• 英文名称: 1,5-anhydroglucitol-6-phosphate
• 英文别名: [(2R,3S,4R,5S)-3,4,5-trihydroxyoxan-2-yl]methyl dihydrogen phosphate
• CAS: 17659-59-5
• 化学式: C₆H₁₃O₈P
• 分子量: 244.138
• InChiKey: KAJAXXUCVJFKFM-SLPGGIOYSA-N

物化性质

• 沸点：
  534.5±60.0 °C(Predicted)
• 密度：
  1.807±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,5-无水葡萄糖醇 在 platinum(IV) oxide 、 1,5-anhydro-2,3-dipivaloyl-4,6-O-benzylidene-D-glucitol 、 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 1,5-脱水山梨糖醇-6-磷酸酯
  参考文献：
  名称：

  1,5-脱水-d-葡萄糖醇6-磷酸的短而有效的合成

  摘要：

  由甲基-d-葡糖苷以高收率和纯度制备重要的d-葡萄糖和d-葡萄糖6-磷酸类似物1，5-脱水-d-葡萄糖醇和1，5-脱水-d-葡萄糖醇6-磷酸。保护羟基作为它们的烯丙基醚，然后用三乙基硅烷还原性切割糖苷键，形成了被保护的脱水葡萄糖醇。在还原步骤中未观察到环重排或环收缩。使用PdCl 2 -CuCl 2活化的木炭系统，烯丙基醚键在低催化剂负载量（每个烯丙基0.0025当量）的作用下断裂。通过将1，5-脱水-d-葡萄糖醇磷酸化来制备1，5-脱水-d-葡萄糖醇6-磷酸。

  DOI：

  10.1016/j.tetlet.2011.07.082

文献信息

• STABILIZING AGENT FOR MANAGEMENT SAMPLE, MANAGEMENT SAMPLE CONTAINING THE STABILIZING AGENT, AND MEASUREMENT KIT COMPRISING THE MANAGEMENT SAMPLE
  申请人：BML, Inc.

  公开号：EP2405275A1

  公开（公告）日：2012-01-11

  An object of the present invention is to provide a control material which can be preferably employed in detection of 1,5-anhydro-D-glucitol and glycoalbumin, which are employed as excellent indices for diabetes. The present inventor has found that mannitol which is added to serum or plasma used as control material stabilizes 1,5-anhydro-D-glucitol and glycoalbumin present in the serum or plasma for a long period of time, and that the object can be attained through provision of (1) an agent for stabilizing control material, the agent being composed of mannitol and (2) control material containing mannitol and 1,5-anhydro-D-glucitol.

  本发明的一个目的是提供一种对照材料，它可以优选用于检测 1,5-脱水-D-葡萄糖醇和糖化白蛋白，这两种物质被用作糖尿病的优良指标。 本发明者发现，添加到用作对照材料的血清或血浆中的甘露醇可长期稳定血清或血浆中的 1,5-脱水-D-葡萄糖醇和糖化白蛋白，通过提供（1）稳定对照材料的制剂（该制剂由甘露醇组成）和（2）含有甘露醇和 1,5-脱水-D-葡萄糖醇的对照材料，可实现本发明的目的。
• Ferrari et al., Archives of Biochemistry, 1959, vol. 80, p. 372,373
  作者：Ferrari et al.

  DOI：——

  日期：——
• Method for measuring glycated albumin contained in serum or plasma using mannitol as stabiliser for a control serum or plasma.
  申请人：BML, Inc.

  公开号：EP2405275B1

  公开（公告）日：2018-10-10
• JPH10191998A
  申请人：——

  公开号：JPH10191998A

  公开（公告）日：1998-07-28
• STABILIZING AGENT FOR CONTROL MATERIAL, CONTROL MATERIAL CONTAINING THE STABILIZING AGENT, AND MEASUREMENT KIT COMPRISING THE CONTROL MATERIAL
  申请人：Tsuboi Isami

  公开号：US20120003743A1

  公开（公告）日：2012-01-05

  An object of the present invention is to provide a control material which can be preferably employed in detection of 1,5-anhydro-D-glucitol and glycoalbumin, which are employed as excellent indices for diabetes. The present inventor has found that mannitol which is added to serum or plasma used as control material stabilizes 1,5-anhydro-D-glucitol and glycoalbumin present in the serum or plasma for a long period of time, and that the object can be attained through provision of (1) an agent for stabilizing control material, the agent being composed of mannitol and (2) control material containing mannitol and 1,5-anhydro-D-glucitol.