1-(1-羟基环戊基)环己烷-1-醇 | 20170-99-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(1-羟基环戊基)环己烷-1-醇
• 英文名称: 1-Cyclopentyl-cyclohexandiol-(1,1')
• 英文别名: Cyclopentylcyclohexan-1,1'-diol；1-(1-Hydroxycyclopentyl)cyclohexanol；1-(1-hydroxycyclopentyl)cyclohexan-1-ol
• CAS: 20170-99-4
• 化学式: C₁₁H₂₀O₂
• 分子量: 184.279
• InChiKey: FLPGXRXHSWPSFZ-UHFFFAOYSA-N

物化性质

• 熔点：
  102-103 °C
• 沸点：
  292.5±8.0 °C(Predicted)
• 密度：
  1.154±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2906199090

反应信息

• 作为反应物：
  描述：

  1-(1-羟基环戊基)环己烷-1-醇 在 三氟化硼乙醚 、 magnesium sulfate 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以73.9%的产率得到螺[4.6]十一烷-11-酮
  参考文献：
  名称：

  Study of I-Strain Relief in the Intermediate When Forming Spiro Ketones from Unsymmetrical Cycloalkylidenecycloalkanes, Their Dibromides, and Their Pinacols

  摘要：

  Three unsymmetrical intercyclic olefins, their dibromides, and their pinacols were prepared, each so the two carbons involved at the functional group were part of a different sized ring. The pinacols were reacted with 25% sulfuric acid and with boron trifluoride etherate, the dibromides with silver nitrate,and the olefins with mercuric acetate and with trifluoroperacetic acid. The predominant spiro ketone found in each product mixture was used to determine which carbon, and hence which size ring, could better undergo the sp(3) to sp(2) or the sp(2) to sp(3) transition. The findings were consistent with Brown's observations on ring strain.

  DOI：

  10.1021/jo00081a030
• 作为产物：
  描述：

  环己酮 、 环戊酮 在 氢化铝 作用下， 以7.3%的产率得到[1,1′-二环戊基]-1,1'-二醇
  参考文献：
  名称：

  Study of I-Strain Relief in the Intermediate When Forming Spiro Ketones from Unsymmetrical Cycloalkylidenecycloalkanes, Their Dibromides, and Their Pinacols

  摘要：

  Three unsymmetrical intercyclic olefins, their dibromides, and their pinacols were prepared, each so the two carbons involved at the functional group were part of a different sized ring. The pinacols were reacted with 25% sulfuric acid and with boron trifluoride etherate, the dibromides with silver nitrate,and the olefins with mercuric acetate and with trifluoroperacetic acid. The predominant spiro ketone found in each product mixture was used to determine which carbon, and hence which size ring, could better undergo the sp(3) to sp(2) or the sp(2) to sp(3) transition. The findings were consistent with Brown's observations on ring strain.

  DOI：

  10.1021/jo00081a030

文献信息

• [EN] PYRIDINYLPYRAZOLES FOR USE AS KINASE MODULATORS FOR THE TREATMENT OF CANCER<br/>[FR] PYRIDINYLPYRAZOLES DESTINÉS À ÊTRE UTILISÉS COMME MODULATEURS DE KINASE DANS LE TRAITEMENT DU CANCER
  申请人：SYNOVO GMBH

  公开号：WO2013046041A1

  公开（公告）日：2013-04-04

  Compounds of the substituted pyrazole class of Formula (I) as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases is described. Said method is effective and can be provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.

  报道了公式（I）的取代吡唑类化合物作为治疗癌症的方法。描述了一种抑制受体激酶活性的化合物治疗癌症的方法。该方法是有效的，并可在标准治疗，特别是使用细胞毒性药物的化疗和其他形式的免疫疗法，包括治疗性疫苗的基础上提供。
• Catalytic composition of organotin compounds
  申请人：Roder Jens

  公开号：US20060047101A1

  公开（公告）日：2006-03-02

  The present invention relates to catalytic compositions for esterification, transestrification and polycondensation reactions, a process for the catalysis of said reactions employing such catalytic compositions and polyesters for resins obtainable by this process.

  本发明涉及用于酯化、转酯化和聚缩反应的催化组合物，使用这种催化组合物进行催化反应的过程以及通过该过程获得的树脂用聚酯。
• KINASE MODULATORS FOR THE TREATMENT OF CANCER
  申请人：Synovo GmbH

  公开号：US20140336225A1

  公开（公告）日：2014-11-13

  Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases. Said method is effective and can be provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.

  报道了替代吡唑类化合物作为治疗癌症的方法。一种治疗癌症的方法是使用抑制受体激酶活性的化合物。该方法是有效的，并可在标准疗法中提供，特别是化疗使用细胞毒药物和其他形式的免疫疗法，包括治疗性疫苗。
• VITAMIN D RECEPTOR MODULATORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1836151B1

  公开（公告）日：2009-04-01
• US4837225A
  申请人：——

  公开号：US4837225A

  公开（公告）日：1989-06-06