1-(2-乙氧基乙氧基)己烷 | 32657-43-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(2-乙氧基乙氧基)己烷
• 英文名称: 1-(2-ethoxyethoxy)hexane
• 英文别名: 1-(ethoxyethoxy)hexane
• CAS: 32657-43-5
• 化学式: C₁₀H₂₂O₂
• 分子量: 174.283
• InChiKey: CMZCBYJFESJOFV-UHFFFAOYSA-N

物化性质

• 沸点：
  204.3±8.0 °C(Predicted)
• 密度：
  0.844±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-乙氧基乙氧基)己烷 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以69%的产率得到乙醛缩二己醇
  参考文献：
  名称：

  Preparation of formaldehyde and acetaldehyde acetals

  摘要：

  DOI：

  10.1021/jo00327a032
• 作为产物：
  描述：

  2-(2-Ethoxyethoxy)ethyl trifluoromethanesulfonate 、 正丁基氯化镁 在 dilithium tetrachlorocuprate 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 1.0h， 以90%的产率得到1-(2-乙氧基乙氧基)己烷
  参考文献：
  名称：

  烷基三氟甲磺酸酯与主要烷基格氏试剂的改进的铜催化交叉偶联反应

  摘要：

  金属催化的交叉偶联反应是强大的碳-碳键形成过程，在过去的三十年中受到了极大的关注。这种方法已被广泛用作合成各种天然产物、生物活性化合物和许多其他高度复杂的有机精细化学品的便捷工具？该方法包括甲苯磺酸盐与格氏试剂的反应，由不同金属催化，从昂贵且生理学上可疑的贵金属到廉价且毒理学上无害的铁盐？这种方法的主要限制是甲苯磺酸盐的置换通常需要剧烈的反应条件。三氟甲磺酸酯已被认为是溶剂分解置换反应中反应性最强的离去基团之一，并且在与炔基锂试剂的交叉偶联反应中确实显示出比相应的甲苯磺酸酯高得多的活性？这表明三氟甲磺酸酯应该更容易与有机金属亲核试剂偶联，因此将扩大可参与交叉偶联反应的缺电子底物的范围。如前所述，“甲苯磺酸盐与格氏试剂的交叉偶联反应已通过使用铜催化剂四氯铜酸二锂（Li，CuCl，）得到改善。已经报道了在相同条件下用三氟甲磺酸盐代替甲苯磺酸盐的尝试；然而，需要存在等摩尔量的溴化亚铜 (CuBr)

  DOI：

  10.1080/00304940809458090

文献信息

• [EN] ANTIMICROBIAL COMPOPSITION COMPRISING A POLYMERIC BIGUANIDE AND A COPOLYMER AND THEIR USE THEREOF<br/>[FR] COMPOSITION ANTIMICROBIENNE CONTENANT UN BIGUANIDE POLYMERIQUE ET UN COPOLYMERE ET UTILISATION ASSOCIEE
  申请人：ARCH UK BIOCIDES LTD

  公开号：WO2004100663A1

  公开（公告）日：2004-11-25

  The present invention relates to a composition comprising: (i) an antimicrobial agent; and (ii) a non-ionic co-polymer of Formula (1) wherein: [A] is of Formula (9), [B] is of Formula (10), and [X] is of Formula (11), wherein [A] and [B] may be in any order; T is an optionally substituted substituent; L is an optionally substituted linking group; R1, R2 and R3 are each independently H, optionally substituted C1-20-alkyl or optionally substituted C 3-20-cycloalkyl; R4 and R5 are each independently H or C1-4alkyl; q is 15 to 1000; p is 3 to 50; and the molar ratio of [A] to [B] (m:n), is 1:10 to 10:1; provided that R1, R2, R3, T and L do not contain an ionisable group and provided that at least one of R4 and R5 is H.

  本发明涉及一种组合物，包括：(i)一种抗菌剂；和(ii)一种非离子共聚物，其化学式为(1)，其中：[A]的化学式为(9)，[B]的化学式为(10)，[X]的化学式为(11)，其中[A]和[B]可以以任何顺序存在；T是可选的取代基；L是可选的取代连接基；R1、R2和R3分别是H、可选的取代C1-20烷基或可选的取代C3-20环烷基；R4和R5分别是H或C1-4烷基；q为15至1000；p为3至50；[A]与[B]的摩尔比(m:n)为1:10至10:1；但要求R1、R2、R3、T和L不含有离子化基团，并且至少有一个R4和R5是H。
• Composition and use
  申请人：Hodge John David

  公开号：US20050008534A1

  公开（公告）日：2005-01-13

  The present invention relates to a composition comprising: (i) an anti-microbial agent comprising a polymeric biguanide, alone or in combination with at least one other microbiologically active component selected from the group consisting of quaternary ammonium compounds, monoquaternary heterocyclic amine salts, urea derivatives, amino compounds, imidazole derivatives, nitrile compounds, tin compounds or complexes, isothiazolin-3-ones, thiazole derivatives, nitro compounds, iodine compounds, aldehyde release agents, thiones, triazine derivatives, oxazolidine and derivatives thereof, furan and derivatives thereof, carboxylic acids and the salts and esters thereof, phenol and derivatives thereof, sulphone derivatives, imides, thioamides, 2-mercapto-pyridine-N-oxide, azole fungicides, strobilurins, amides, carbamates, pyridine derivatives, compounds with active halogen groups, and organometallic compounds; and (ii) an amphoteric co-polymer of the Formula (1): wherein: [A] is of Formula (9), [B] is of Formula (10), [C] is of Formula (12), [D] is of Formula (13), and X is of Formula (11), wherein [A], [B], [C] and [D] may occur in any order; T is an optionally substituted substituent; L, G and Z each independently is an optionally substituted linking group; R 1 , R 2 and R 3 are each independently H, optionally substituted C 1-20 -alkyl or optionally substituted C 3-20 -cycloalkyl; R 4 and R 5 are each independently H or C 1-4 -alkyl; q is 15 to 1000; p is 3 to 50; J is an optionally substituted hydrocarbyl group; F is an acidic substituent; E is a basic substituent; m is 0 to 350; n is 1 to 75; v is 0 to 100; y is 1 to 100; b is 0, 1 or 2; s is 0 or 1; w is 1 to 4; and provided that at least one of R 4 and R 5 is H.

  本发明涉及一种组合物，包括：（i）一种抗微生物剂，包括聚合物双胍，单独或与从季铵化合物、单季铵杂环胺盐、脲衍生物、氨基化合物、咪唑衍生物、腈化合物、锡化合物或配合物、异噻唑啉-3-酮、噻唑衍生物、硝基化合物、碘化合物、醛释放剂、硫醇、三嗪衍生物、氧氮杂环和其衍生物、呋喃和其衍生物、羧酸及其盐和酯、酚及其衍生物、磺酰基衍生物、酰亚胺、硫酰胺、2-巯基吡啶-N-氧化物、唑类杀菌剂、链霉素、酰胺、氨基甲酸酯、吡啶衍生物、具有活性卤素基团的化合物和有机金属化合物中选择至少一种其他微生物活性成分组合而成；和（ii）式（1）的两性共聚物：其中：[A]为式（9）；[B]为式（10）；[C]为式（12）；[D]为式（13）；且X为式（11），其中[A]，[B]，[C]和[D]可以以任何顺序出现；T为可选的取代基；L，G和Z各自独立地为可选的取代连接基；R1，R2和R3各自独立地为H，可选的取代C1-20烷基或可选的取代C3-20环烷基；R4和R5各自独立地为H或C1-4烷基；q为15至1000；p为3至50；J为可选的取代的烃基；F为酸性取代基；E为碱性取代基；m为0至350；n为1至75；v为0至100；y为1至100；b为0、1或2；s为0或1；w为1至4；并且至少R4和R5中的一个为H。
• [EN] COMPOSITION COMPRISING AN ACIDIC COPOLYMER AND AN ANTIMICROBIAL AGENT AND USE THEREOF<br/>[FR] COMPOSITION CONTENANT UN COPOLYMERE ACIDE ET UN AGENT ANTIMICROBIEN, ET SON UTILISATION
  申请人：ARCH UK BIOCIDES LTD

  公开号：WO2004100664A1

  公开（公告）日：2004-11-25

  A composition comprising: (i) an anti-microbial agent; and (ii) an acidic co-polymer of the Formula (1) wherein: [A] is of Formula (9), [B] is of Formula (10), and [C] is of Formula (12) wherein: [X] is of Formula (11), wherein [A], [B] and [C] may occur in any order; T is an optionally substituted substituent; L and G each independently is an optionally substituted linking group; R1, R2 and R3 are each independently H, optionally substituted C1-20-alkyl or optionally substituted C3-20-cycloalkyl; R4 and R5 are each independently H or C1-4-alkyl; q is 15 to 1000; p is 3 to 50; J is an optionally substituted hydrocarbyl, group; F is an acidic substituent; b is 0, 1, or 2; m is 0 to 350; n is 1 to 75; v is 1 to 100; and w is 1 to 4; provided that at least one of R4 and R5 is H and provided that R1, R2, R3, T, L, J and G do not contain a basic group; and wherein the pka value of the acidic substituent F on the monomer from which [C] is derived is less than 5.5.

  一种组合物，包括：(i)一种抗微生物剂；和(ii)式(1)的酸性共聚物，其中：[A]为式(9)，[B]为式(10)，[C]为式(12)，其中：[X]为式(11)，[A]、[B]和[C]可以以任何顺序出现；T是可选取代基；L和G各自独立地为可选取代连接基团；R1、R2和R3各自独立地为H、可选取代的C1-20烷基或可选取代的C3-20环烷基；R4和R5各自独立地为H或C1-4烷基；q为15到1000；p为3到50；J为可选取代的烃基团；F为酸性取代基；b为0、1或2；m为0到350；n为1到75；v为1到100；w为1到4；至少R4和R5中的一个为H，并且R1、R2、R3、T、L、J和G不含有碱性基团；其中，[C]所衍生的单体中酸性取代基F的pka值小于5.5。
• [EN] ANTIMICROBIAL COMPOSITION CONTAINING A POLYMERIC BIGUADINE AND A COPOLYMER AND USE THEREOF<br/>[FR] COMPOSITION ANTIMICROBIENNE CONTENANT UN BIGUANIDE POLYMERIQUE ET UN COPOLYMERE ET SON APPLICATION
  申请人：ARCH UK BIOCIDES LTD

  公开号：WO2004100666A1

  公开（公告）日：2004-11-25

  The present invention relates to a composition comprising: an anti-microbial agent comprising a polymeric biguanide, alone or in combination with at least one other microbiologically active component selected from the group consisting of quaternary ammonium compounds, monoquaternary heterocyclic amine salts, urea derivatives, amino compounds, imidazole derivatives, nitrile compounds, tin compounds or complexes, isothiazolin-3-ones, thiazole derivatives, nitro compounds, iodine compounds, aldehyde release agents, thiones, triazine derivatives, oxazolidine and derivatives thereof, furan and derivatives thereof, carboxylic acids and the salts and esters thereof, phenol and derivatives thereof, sulphone derivatives, imides, thioamides, 2-mercapto-pyridine-N-oxide, azole fungicides, strobilurins, amides, carbamates, pyridine derivatives, compounds with active halogen groups, and organometallic compounds; and an amphoteric co-polymer of the Formula (1); wherein [A] is of Formula (9), [B] is of Formula (10), [C] is of Formula (12), [D] is of Formula (13), and X is of Formula (11),wherein [A], [B], [C] and [D] may occur in any order; T is an optionally substituted substituent; L, G and Z each independently is an optionally substituted linking group; R1, R2 and R3 are each independently H, optionally substituted Cl-20-alkyl or optionally substituted C3-20-cycloalkyl; R4 and R5 are each independently H or C1-4-alkyl; q is 15 to 1000; p is 3 to 50; J is an optionally substituted hydrocarbyl group; F is an acidic substituent; E is a basic substituent; m is 0 to 350; n is 1 to 75; v is 0 to 100; y is 1 to 100; b is 0, 1 or 2; s is 0 or 1; w is 1 to 4; and provided that at least one of R4 and R5 is H.

  本发明涉及一种组合物，包括：一种抗微生物剂，包括聚大双胍，单独使用或与至少一种从季铵化合物、单季铵杂环胺盐、脲衍生物、氨基化合物、咪唑衍生物、腈化合物、锡化合物或配合物、异噻唑啉-3-酮、噻唑衍生物、硝基化合物、碘化合物、醛释放剂、硫醇、三嗪衍生物、噁唑烷及其衍生物、呋喃及其衍生物、羧酸及其盐和酯、苯酚及其衍生物、磺酰衍生物、亚酰胺、硫代酰胺、2-巯基吡啶-N-氧化物、咪唑类杀菌剂、斑点灵、酰胺、氨基甲酸酯、吡啶衍生物、具有活性卤素基团的化合物和有机金属化合物中选择的至少一种具有微生物活性成分；以及公式（1）的两性共聚物，其中[A]为公式（9），[B]为公式（10），[C]为公式（12），[D]为公式（13），X为公式（11），其中[A]，[B]，[C]和[D]可以以任何顺序出现；T是可选取代基；L，G和Z各自独立地是可选取代的连接基；R1，R2和R3各自独立地是H、可选取代的Cl-20-烷基或可选取代的C3-20-环烷基；R4和R5各自独立地是H或C1-4-烷基；q为15至1000；p为3至50；J为可选取代的烃基；F为酸性取代基；E为碱性取代基；m为0至350；n为1至75；v为0至100；y为1至100；b为0、1或2；s为0或1；w为1至4；并且至少有一个R4和R5为H。
• [EN] ANTIMICROBIAL COMPOSITION COMPRISING A POLYMERIC BIGUANIDE AND A COPOLYMER AND USE THEREOF<br/>[FR] COMPOSITION ANTIMICROBIENNE CONTENANT UN BIGUANIDE DE POLYMERE AINSI QU'UN COPOLYMERE ET SON UTILISATION
  申请人：ARCH UK BIOCIDES LTD

  公开号：WO2004100665A1

  公开（公告）日：2004-11-25

  The present invention relates to a composition comprising: (i) an anti-microbial agent; and (ii) a basic co-polymer of the Formula (1):) wherein [A] is of Formula (9), [B] is of Formula (10), and [D] is of Formula (12), Formula (13) X is of Formula (11), wherein [A], [B] and [D] may occur in any order; T is an optionally substituted substituent; L and Z each independently is an optionally substituted linking group; R1, R2 and R3 are each independently H; optionally substituted Cl-20-alkyl or optionally substituted C3-20-cycloalkyl; R4 and R5 are each independently H or C1-4-alkyl; E is a basic substituent; q is 15 to 1000; m is 0 to 350; n is 1 to 75; y is 1 to 100; s is 0 or 1; p is 3 to 50; and provided that at least one of R4 and R5 is H and provided that R1, R2, R3, T, L and Z do not contain an acidic group which can protonate E on [D].

  本发明涉及一种组合物，包括：(i)一种抗微生物剂；以及(ii)一种公式(1)的碱性共聚物：其中[A]为公式(9)，[B]为公式(10)，[D]为公式(12)，公式(13)中X为公式(11)，其中[A]、[B]和[D]可以以任何顺序出现；T为可选取代基；L和Z各自独立地为可选取代的连接基；R1、R2和R3各自独立地为H、可选取代的Cl-20-烷基或可选取代的C3-20-环烷基；R4和R5各自独立地为H或C1-4-烷基；E为碱性取代基；q为15至1000；m为0至350；n为1至75；y为1至100；s为0或1；p为3至50；并且至少R4和R5中的一个为H，且R1、R2、R3、T、L和Z不含有可以质子化[D]上的E的酸性基团。