杀木膦 | 59682-52-9

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 杀木膦
• 英文名称: fosamine
• 英文别名: carbamoyl(ethoxy)phosphinic acid
• CAS: 59682-52-9
• 化学式: C₃H₈NO₄P
• mdl: MFCD01706371
• 分子量: 153.075
• InChiKey: UCHDFLNGIZUADY-UHFFFAOYSA-N

物化性质

• 沸点：
  290.3±23.0 °C(Predicted)
• 密度：
  1.432±0.06 g/cm3(Predicted)
• 颜色/状态：
  COLORLESS CRYSTALLINE SOLID
• 熔点：
  175 °C
• 溶解度：
  @ 25 °C: 1.79 KG/KG WATER, 300 MG/KG ACETONE, 400 MG/KG BENZENE, 12 G/KG ETHANOL, 1.4 G/KG DIMETHYLFORMAMIDE, 158 G/KG METHANOL, 200 MG/KG HEXANE
• 蒸汽压力：
  0.53 mPa @ 25 °C
• 稳定性/保质期：

  AQUEOUS FORMULATIONS AND DILUTED SPRAYS ARE STABLE, BUT IT DECOMP IN ACID MEDIA IN DILUTE SOLN (5 MG/L) ... .

• 分解：
  Decomposes in dilute solutions of acids.
• 腐蚀性：
  Corrosive to copper and brass.

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

代谢

被淘汰的(14)C在大便和尿液中是87%完整的福酰胺，约13%是碳酰胺磷酸。

THE ELIMINATED (14)C IN URINE & FECES WAS 87% INTACT FOSAMINE AND ABOUT 13% CARBAMOYLPHOSPHONIC ACID.

来源:Hazardous Substances Data Bank (HSDB)

代谢

有机磷化合物的代谢主要通过氧化作用、酯酶的水解作用以及与谷胱甘肽的反应进行。去甲基化和葡萄糖醛酸化也可能发生。有机磷农药的氧化可能导致产生中等毒性的产物。一般来说，硫代磷酸酯本身并不具有直接毒性，但需要通过氧化代谢转化为近端毒素。谷胱甘肽转移酶反应产生的产物在大多数情况下毒性较低。福森胺迅速通过身体；主要随粪便排出，较少随尿液排出。它不会在哺乳动物体内生物累积（积聚）。

Metabolism of organophosphates occurs principally by oxidation, and hydrolysis by esterases and by reaction with glutathione. Demethylation and glucuronidation may also occur. Oxidation of organophosphorus pesticides may result in moderately toxic products. In general, phosphorothioates are not directly toxic but require oxidative metabolism to the proximal toxin. The glutathione transferase reactions produce products that are, in most cases, of low toxicity. Fosamine rapidly passes through the body; elimination is primarily in the feces and less in the urine. It does not bioaccumulate (build up) in mammals.

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

福萨明是一种眼刺激物。它可能结合或修改TRPA1蛋白，从而导致催泪（流泪）反应。

Fosamine is an eye irritant. It likely binds to or modifies the TRPA1 protein which leads to a lachrymatory (tearing) response.

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

职业暴露于福赛胺是通过皮肤接触和吸入粉尘及喷雾发生的，尤其是对那些将其作为除草剂应用的工人。如果个人意外吸入或食用残留物，福赛胺的毒性低到非常低；如果接触，则有中等毒性。它对眼睛不刺激，但可能导致轻微到中度的皮肤刺激。福赛胺可能引起中度眼睛伤害或刺激。在一项亚慢性口服研究中，接受最高剂量的实验动物表现出一些统计学上显著的影响，包括对肾脏、膀胱的影响以及体重的下降。

Occupational exposure to fosamine occurs through dermal contact and inhalation of dust and sprays, especially to workers applying the compound as a herbicide. Fosamine has low to very low toxicity if individuals accidentally inhale or eat residues and has moderate toxicity if touched. It is not irritating to the eyes, but it can cause mild to moderate skin irritation. Fosamine can cause moderate eye injury or irritation. In one subchronic oral study, the laboratory animals given the highest dose exhibited some statistically significant effects, including effects to the kidneys, bladder and decreases in body weight.

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

吸入 (L793)；口服 (L793)；皮肤给药 (L793)

Inhalation (L793) ; oral (L793); dermal (L793)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

Fosamine 如果个体意外吸入或食用残留物，其毒性很低到非常低，如果接触到，则有中等毒性。它对眼睛无刺激性，但可能导致轻微到中度的皮肤刺激。Fosamine 不是一种皮肤致敏剂。

Fosamine has low to very low toxicity if individuals accidentally inhale or eat residues and has moderate toxicity if touched. It is not irritating to the eyes, but it can cause mild to moderate skin irritation. Fosamine is not a skin sensitizer.

来源:Toxin and Toxin Target Database (T3DB)

吸收、分配和排泄

当通过胃内插管将ADMIN作为单一口服剂量给予预处理的大鼠时，放射性物质迅速通过粪便（87%）和尿液（13%）排出。在消化道、隐藏物和呼出的空气中发现了微量放射性物质，72小时后在身体组织中发现了放射性物质。

WHEN ADMIN AS A SINGLE ORAL DOSE TO PRECONDITIONED RATS BY INTRAGASTRIC INTUBATION, RADIOACTIVITY WAS RAPIDLY ELIMINATED IN FECES (87%) & URINE (13%). TRACE AMT FOUND IN THE GI TRACT, HIDE & EXHALED AIR RADIOACTIVITY FOUND IN BODY TISSUES AFTER 72 HR.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

通过叶片吸收（不是通过根系）。在植物中没有向下输送。

Uptake via leaves, (not via roots). No downward transport in the plant.

来源:Hazardous Substances Data Bank (HSDB)