杀黑星菌素A | 33538-71-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 杀黑星菌素A
• 英文名称: Venturicidin A
• 英文别名: [(2R,3R,4R,6R)-3-hydroxy-6-[[(1R,5S,6R,8R,9E,11R,15E,17R)-1-hydroxy-5-[(2R,4R,5S,6S)-5-hydroxy-4,6-dimethyl-7-oxononan-2-yl]-6,8,16,18-tetramethyl-3-oxo-4,21-dioxabicyclo[15.3.1]henicosa-9,15,18-trien-11-yl]oxy]-2-methyloxan-4-yl] carbamate
• CAS: 33538-71-5
• 化学式: C₄₁H₆₇NO₁₁
• 分子量: 750.0
• InChiKey: HHQKNFDAEDTRJK-LIOWZGMGSA-N

物化性质

• 熔点：
  145-147°; mp 140-142°
• 比旋光度：
  D +119° (c = 0.5 in chloroform)
• 沸点：
  874.9±65.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)
• 溶解度：
  DMF：可溶； DMSO：可溶；乙醇：可溶；甲醇：可溶

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  53
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  184
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• CRP CAPTURE/DETECTION OF BACTERIA
  申请人：President and Fellows of Harvard College

  公开号：EP3912986A2

  公开（公告）日：2021-11-24

  Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

  本文描述的是工程微生物靶向分子、微生物靶向物品、包含这些物质的试剂盒及其用途。这些微生物靶向分子、微生物靶向物品或包含它们的试剂盒可以结合或捕获微生物或其中的微生物物质，因此可用于各种应用，如诊断或治疗由微生物引起的受试者或任何环境表面的感染。
• Microbe-binding molecules and uses thereof
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US10435457B2

  公开（公告）日：2019-10-08

  Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.

  本文描述的是工程微生物靶向分子、微生物靶向物品、包含这些物质的试剂盒及其用途。这些微生物靶向分子、微生物靶向物品或包含它们的试剂盒不仅能结合或捕获微生物或微生物物质，而且还能提高检测微生物或微生物物质的能力（例如，提高灵敏度或信号强度）。因此，本文所述的微生物靶向分子、微生物靶向物品和/或试剂盒可用于各种应用，例如但不限于用于检测微生物或微生物物质的化验、用于诊断和/或治疗微生物在受试者或任何环境表面引起的感染的诊断和/或治疗剂，和/或用于从流体中清除微生物或微生物物质的装置。
• CRP capture/detection of gram positive bacteria
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US10513546B2

  公开（公告）日：2019-12-24

  Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

  本文描述的是工程微生物靶向分子、微生物靶向物品、包含这些物质的试剂盒及其用途。这些微生物靶向分子、微生物靶向物品或包含它们的试剂盒可以结合或捕获微生物或其中的微生物物质，因此可用于各种应用，如诊断或治疗由微生物引起的受试者或任何环境表面的感染。
• Bacteriophages expressing antimicrobial peptides and uses thereof
  申请人：Collins James J.

  公开号：US10676721B2

  公开（公告）日：2020-06-09

  The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.

  本发明一般涉及表达抗菌肽或溶菌酶或其片段的工程噬菌体，用于靶向广谱细菌宿主，长期抑制细菌的噬菌体抗药性，以减少细菌感染。在某些实施方案中，噬菌体表达的抗菌肽或抗菌多肽（如噬菌体溶解酶）是从宿主细菌中分泌出来的，或者在细菌宿主细胞裂解时释放出来。本发明的各方面还涉及使用工程噬菌体来减少细菌感染，包括在临床环境和伤口愈合中用于主体或生物修复目的。
• Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US10842812B2

  公开（公告）日：2020-11-24

  Methods of promoting hypoxia or the hypoxia response for the treatment or prevention of mitochondrial dysfunction and oxidative stress disorders are described. Methods for screening for targets of mitochondrial dysfunction and oxidative stress disorders are also described.

  描述了促进缺氧或缺氧反应以治疗或预防线粒体功能障碍和氧化应激紊乱的方法。还描述了筛选线粒体功能障碍和氧化应激紊乱靶标的方法。