1-(4-羟基-3-甲氧基苯基)-2-(2-甲氧基苯氧基)-1-丙醇 | 1774-10-3

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 中文名称: 1-(4-羟基-3-甲氧基苯基)-2-(2-甲氧基苯氧基)-1-丙醇
• 英文名称: 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1-propanol
• 英文别名: 4-[1-hydroxy-2-(2-methoxyphenoxy)propyl]-2-methoxyphenol；1-Hydroxy-2-methoxy-4-<2-(2-methoxy-phenoxy)-1-hydroxy-propyl>-benzol；2-(2-Methoxy-phenoxy)-1-(3-methoxy-4-hydroxy-phenyl)-propanol-(1)；2-(2-Methoxy-phenoxy)-1-(4-hydroxy-3-methoxy-phenyl)-propanol；β-Guajacoxymethylisoeugenolglycol
• CAS: 1774-10-3
• 化学式: C₁₇H₂₀O₅
• 分子量: 304.343
• InChiKey: QJGIDXOMZMVHIJ-UHFFFAOYSA-N

物化性质

• 熔点：
  60-65 °C
• 沸点：
  478.9±45.0 °C(Predicted)
• 密度：
  1.206±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-羟基-3-甲氧基苯基)-2-(2-甲氧基苯氧基)-1-丙醇 生成 (E)-2-甲氧基-4-(1-丙烯基苯酚)
  参考文献：
  名称：

  POPPIUS, K.;BRUNOW, G., INT. SYMP. WOOD AND PULP. CHEM., VANCOUVER, AUG. 26-30, 1985, S. L., 1911+

  摘要：

  DOI：
• 作为产物：
  描述：

  4'-Hydroxy-3'-methoxy-2-(2-methoxy-phenoxy)-propiophenon 、 硼氢化钠 以86%的产率得到
  参考文献：
  名称：

  ZAKIS G. F., XIMIYA DREVESINY, 1979, HO 1, 97-103

  摘要：

  DOI：

文献信息

• Chemodivergent hydrogenolysis of eucalyptus lignin with Ni@ZIF-8 catalyst
  作者：Xue Liu、Helong Li、Ling-Ping Xiao、Run-Cang Sun、Guoyong Song

  DOI：10.1039/c8gc03511c

  日期：——

  Chemodivergent hydrogenolysis of eucalyptus biomass leading to 4-propanol- or 4-propyl-substituted phenols, together with a well-preserved carbohydrate component, was achieved by using Ni@ZIF-8 catalyst.

  通过使用Ni@ZIF-8催化剂，实现了对桉树木质素的化学多样性氢解，产生了4-丙醇或4-丙基取代的酚类化合物，同时保留了良好的碳水化合物组分。

• Cooling Agent and TRPM8 Activator
  申请人：Kao Corporation

  公开号：US20140329910A1

  公开（公告）日：2014-11-06

  Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein R 1 represents a hydrogen atom; R 2 represents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; R 3 represents a hydrogen atom or a hydroxyl group; R 4 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; R 5 represents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and R 6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

  提供了一种具有出色的TRPM8激活作用的冷却剂、一种TRPM8激活剂、一种赋予冷感的方法，以及一种用于赋予冷感的新化合物。公开了一种冷却剂，其包括以下式（1）所代表的化合物作为活性成分： 其中R1代表氢原子；R2代表氢原子、羟基或具有1至3个碳原子的烷氧基；R3代表氢原子或羟基；R4代表氢原子、具有1至6个碳原子的烷基、具有2至6个碳原子的烯基，或具有1至3个碳原子的烷氧基；R5代表氢原子或具有1至3个碳原子的烷氧基；R6代表氢原子、羟基、具有1至14个碳原子的烷氧基、总共具有2至12个碳原子的烷氧烷氧基、具有3至12个碳原子的环烷氧基、具有6至12个碳原子的芳基氧基、总共具有7至14个碳原子的芳基烷氧基，或总共具有2至12个碳原子的烷酰氧基。
• COOLING AGENT AND TRPM8 ACTIVATOR
  申请人：Kao Corporation

  公开号：EP2787051A1

  公开（公告）日：2014-10-08

  Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein R1 represents a hydrogen atom; R2 represents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; R3 represents a hydrogen atom or a hydroxyl group; R4 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; R5 represents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and R6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

  本文提供了一种具有出色的 TRPM8 激活作用的降温剂、一种 TRPM8 激活剂、一种赋予降温感觉的方法，以及一种可用于赋予降温感觉的新型化合物。本发明公开了一种降温剂，其活性成分包括下式（1）所代表的化合物： 其中 R1 代表氢原子；R2 代表氢原子、羟基或具有 1 至 3 个碳原子的烷氧基；R3 代表氢原子或羟基；R4 代表氢原子、具有 1 至 6 个碳原子的烷基、具有 2 至 6 个碳原子的烯基或具有 1 至 3 个碳原子的烷氧基；R5 代表氢原子或具有 1 至 3 个碳原子的烷氧基；R6 代表氢原子、羟基、具有 1 至 14 个碳原子的烷氧基、具有 2 至 12 个碳原子的烷氧基、具有 3 至 12 个碳原子的环烷氧基、具有 6 至 12 个碳原子的芳氧基、具有 7 至 14 个碳原子的烷氧基或具有 2 至 12 个碳原子的烷酰氧基。
• JP6163356
  申请人：——

  公开号：——

  公开（公告）日：——
• Adducts of anthrahydroquinone and anthranol with lignin model quinone methides. 1. Synthesis and characterization
  作者：Lawrence L. Landucci、John Ralph

  DOI：10.1021/jo00139a020

  日期：1982.8