1-(7-喹啉氧基)-2,3-环氧丙烷 | 344335-19-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 1-(7-喹啉氧基)-2,3-环氧丙烷
• 英文名称: 1-(7-Quinolyloxy)-2,3-epoxypropane
• 英文别名: 7-(Oxiran-2-ylmethoxy)quinoline
• CAS: 344335-19-9
• 化学式: C₁₂H₁₁NO₂
• 分子量: 201.225
• InChiKey: PLBNMAPJJGIDBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(7-喹啉氧基)-2,3-环氧丙烷 、 4-[3-(4-Amino-phenoxy)-propyl]-2,6-di-tert-butyl-phenol 以 乙醇 为溶剂， 生成 2,6-Ditert-butyl-4-[3-[4-[(2-hydroxy-3-quinolin-7-yloxypropyl)amino]phenoxy]propyl]phenol
  参考文献：
  名称：

  New series of aryloxypropanolamines with both human β3-adrenoceptor agonistic activity and free radical scavenging properties

  摘要：

  A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the beta(3)-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-. di-tert-butylphenolyl- or methoxyindolyl- type. Some of the products possessed both the expected activities. (C) 2002 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0960-894x(01)00716-8
• 作为产物：
  描述：

  7-羟基喹啉 、 环氧溴丙烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-(7-喹啉氧基)-2,3-环氧丙烷
  参考文献：
  名称：

  New series of aryloxypropanolamines with both human β3-adrenoceptor agonistic activity and free radical scavenging properties

  摘要：

  A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the beta(3)-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-. di-tert-butylphenolyl- or methoxyindolyl- type. Some of the products possessed both the expected activities. (C) 2002 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0960-894x(01)00716-8

文献信息

• 5-HT1F antagonists
  申请人：ELI LILLY AND COMPANY

  公开号：EP0976746A1

  公开（公告）日：2000-02-02

  This invention provides 5-HT1f antagonists of Formula I: where AR1, AR2, R, and R' are as defined in the specification.

  本发明提供了式 I 的 5-HT1f 拮抗剂： 其中 AR1、AR2、R 和 R' 如说明书中所定义。
• Use of 5HT-1F receptor antagonists for treating anxiety disorders
  申请人：ELI LILLY AND COMPANY

  公开号：EP0976747A2

  公开（公告）日：2000-02-02

  The present invention provides a method for the treatment of prevention of anxiety disorders which comprises administering to a mammal in need of such treatment a serotonin 5-HT1F receptor antagonist.

  本发明提供了一种治疗和预防焦虑症的方法，该方法包括向需要治疗的哺乳动物施用5-羟色胺5-HT1F受体拮抗剂。
• Agarwal, Shiv K.; Kumar, Yatendra; Saxena, Anil K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 5, p. 435 - 439
  作者：Agarwal, Shiv K.、Kumar, Yatendra、Saxena, Anil K.、Jain, Padam C.、Anand, Nitya

  DOI：——

  日期：——
• AGARWAL, SHIV, K.;KUMAR, YATENDRA;SAXENA, ANIL, K.;JAIN, PADAM, C.;ANAND,+, INDIAN J. CHEM., 1982, 21, N 5, 435-439
  作者：AGARWAL, SHIV, K.、KUMAR, YATENDRA、SAXENA, ANIL, K.、JAIN, PADAM, C.、ANAND,+

  DOI：——

  日期：——
• US6242450B1
  申请人：——

  公开号：US6242450B1

  公开（公告）日：2001-06-05