棕榈酰四肽-10 | 887140-79-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 棕榈酰四肽-10
• 英文名称: Palmitoyl tetrapeptide-10
• 英文别名: (2S)-6-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]hexanoic acid
• CAS: 887140-79-6
• 化学式: C₄₁H₇₂N₆O₇
• 分子量: 761.0
• InChiKey: XCEMXBAGNZCOHW-JPZUFNMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  54
• 可旋转键数：
  33
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  226
• 氢给体数：
  8
• 氢受体数：
  9

文献信息

• Use of a peptide for the treatment of epiderm
  申请人：Sederma

  公开号：US11523980B2

  公开（公告）日：2022-12-13

  A peptide having the general Formula (1) X-(Xaa) n K*TFK*-(Xaa) m -Z  (1) is described, where the peptide helps preserve or improve the condition of the epidermis and wherein X, (Xaa) n , (Xaa) m , n, m, K* and Z are as defined.

  具有通式（1）的多肽 X-(Xaa) n K*TFK*-(Xaa) m -Z (1) 描述了肽有助于保持或改善表皮状况，其中 X、(Xaa) n ，(Xaa) m n、m、K* 和 Z 的定义。
• USE OF A PEPTIDE FOR THE TREATMENT OF EPIDERM
  申请人：SEDERMA

  公开号：EP3773460A1

  公开（公告）日：2021-02-17
• [EN] USE OF A PEPTIDE FOR THE TREATMENT OF EPIDERM<br/>[FR] UTILISATION D'UN PEPTIDE POUR LE TRAITEMENT DE L'ÉPIDERME
  申请人：SEDERMA SA

  公开号：WO2019193113A1

  公开（公告）日：2019-10-10

  The peptide has the general Formula X-(Xaa)nK*TFK*-(Xaa)m-Z. It helps preserve or improve the condition of the epidermis. In the Formula, K* is selected from lysine K, ornithine, diaminobutyric acid or diaminopropionic acid, or a hydroxyl derivative; (Xaa)n and (Xaa)m independently of one another correspond to a sequence of n or m amino acids Xaa independently selected from among Gly, Ala, Pro, Val, Leu, Ile and Phe, with n and m integers which may be equal or different from 0 to 5; at the N-terminus X selected from H, -CO-R1, -SO2-R1 or a biotinoyl group; at the C-terminus Z selected from OH, OR1, NH2, NHR1 or NR1R2; and R1 and R2 being, independently of one another, selected from an alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy group, which may be linear, branched, cyclic, polycyclic, unsaturated, hydroxylated, carbonylated, phosphorylated and/or sulfurated, said group having from 1 to 24 carbon atoms and may possess in its backbone an O, S and/or N heteroatom. A preferred peptide is the Pal-KTFK.