1-(二苯基甲基)-3-甲基-3-羟基氮杂啶盐酸盐 | 133891-86-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(二苯基甲基)-3-甲基-3-羟基氮杂啶盐酸盐
• 英文名称: 1-diphenylmethyl-3-hydroxy-3-methylazetidine hydrochloride
• 英文别名: 1-(diphenylmethyl)-3-methyl-3-azetidinol hydrochloride；1-benzhydryl-3-methyl-azetidin-3-ol hydrochloride；1-(Diphenylmethyl)-3-methylazetidin-3-ol hydrochloride；1-benzhydryl-3-methylazetidin-3-ol;hydrochloride
• CAS: 133891-86-8
• 化学式: C₁₇H₁₉NO*ClH
• 分子量: 289.805
• InChiKey: ASMPVJOSECQRDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.26
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲基磺酰氯 、 1-(二苯基甲基)-3-甲基-3-羟基氮杂啶盐酸盐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以24%的产率得到1-二苯甲基-3-甲磺酰氧基-3-甲基氮杂丁烷
  参考文献：
  名称：

  WO2007/7057

  摘要：

  公开号：
• 作为产物：
  描述：

  甲基环氧氯丙烷 、 邻苄基苯胺 以 甲醇 为溶剂， 反应 92.0h， 以75%的产率得到1-(二苯基甲基)-3-甲基-3-羟基氮杂啶盐酸盐
  参考文献：
  名称：

  WO2007/7057

  摘要：

  公开号：

文献信息

• Phenyloxazolidinone antimicrobials
  申请人：Pharmacia & Upjohn Company

  公开号：US05883093A1

  公开（公告）日：1999-03-16

  The present invention relates to antimicrobial phenyloxazolidinone compounds having a pyrrolidinyl or azetidinyl moiety.

  本发明涉及具有吡咯啉基或氮杂环丁基结构的抗菌苯氧唑啉酮化合物。
• Compositions for dyeing keratinic fibres, containing paraphenylenediamine derivatives with an azetidinyl group
  申请人：——

  公开号：US20030028976A1

  公开（公告）日：2003-02-13

  The invention relates to novel compositions for the oxidation dyeing of keratin fibers, comprising at least one para-phenylenediamine derivative containing an azetidinyl group as oxidation base, to the dyeing process and to the dyeing kit using this composition, and also to novel para-phenylenediamines containing an azetidinyl group.

  本发明涉及一种新型的角蛋白纤维氧化染色组合物，包括至少一种含有氮杂环基团的对苯二胺衍生物作为氧化剂基团，以及该染色过程和使用该组合物的染色套件，还涉及一种新型的含有氮杂环基团的对苯二胺。
• AMINOARYL OXAZOLIDINONE N-OXIDES
  申请人：——

  公开号：US20020177707A1

  公开（公告）日：2002-11-28

  The present invention provides for aminoaryl oxazolidinone N-oxide compounds of Formula I 1 wherein the variables are as defined herein. These compounds are exceedingly water soluble which is useful in preparing pharmaceutical formulations of these compounds. They are also rapidly converted back to the parent amines in vivo, making them useful as prodrugs of the parent amines. They are effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, such as Bacteroides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp., and in organisms such as Mycoplasma spp.

  本发明提供了公式I1中的氨基芳基噁唑啉酮N-氧化物化合物，其中变量如定义所述。这些化合物在水中极易溶解，这对于制备这些化合物的药物配方非常有用。它们也能够在体内迅速转化为原始胺类化合物，这使它们成为原始胺类化合物的前药。它们对许多人类和兽医病原体具有有效作用，包括革兰氏阳性的需氧菌，如耐多种抗生素的葡萄球菌、链球菌和肠球菌，以及厌氧菌，如拟杆菌属和梭菌属物种，和酸性快速生长菌，如结核分枝杆菌、埃及分枝杆菌和分枝杆菌属，以及支原体属等微生物。
• Aminoaryl Oxazolidinone N-oxides
  申请人：——

  公开号：US20010051722A1

  公开（公告）日：2001-12-13

  The present invention provides for aminoaryl oxazolidinone N-oxide compounds of Formula I 1 wherein the variables are as defined herein. These compounds are exceedingly water soluble which is useful in preparing pharmaceutical formulations of these compounds. They are also rapidly converted back to the parent amines in vivo, making them useful as prodrugs of the parent amines. They are effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, such as Bacteroides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp., and in organisms such as Mycoplasma spp.

  本发明提供了一种式为I1的氨基芳基噁唑啉酮N-氧化物化合物，其中变量的定义如本文所述。这些化合物在水中极易溶解，这对于制备这些化合物的药物配方非常有用。它们在体内也能迅速转化回母体胺，因此可作为母体胺的前药物使用。它们对许多人类和兽医病原体具有有效作用，包括革兰氏阳性的需氧菌，如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧菌，如Bacteroides spp.和Clostridia spp.菌种，以及抗酸菌，如结核分枝杆菌、埃及分枝杆菌和分枝杆菌属，以及支原体属等生物。
• Aminoaryl oxazolidinone N-oxides
  申请人：——

  公开号：US20020107402A1

  公开（公告）日：2002-08-08

  The present invention provides for aminoaryl oxazolidinone N-oxide compounds of Formula I 1 wherein the variables are as defined herein. These compounds are exceedingly water soluble which is useful in preparing pharmaceutical formulations of these compounds. They are also rapidly converted back to the parent amines in vivo, making them useful as prodrugs of the parent amines. They are effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, such as Bacteroides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp., and in organisms such as Mycoplasma spp.

  本发明提供了一种公式I1的氨基芳基噁唑烷N-氧化物化合物，其中变量如此处所定义。这些化合物在水中极易溶解，可用于制备这些化合物的制药配方。它们在体内也能迅速转化为母体胺类化合物，因此可用作母体胺类化合物的前药。它们对许多人类和兽医病原体具有有效作用，包括革兰氏阳性的需氧菌，如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧菌，如Bacteroides spp.和Clostridia spp.物种，还有抗酸菌，如结核分枝杆菌、非结核分枝杆菌和分枝杆菌属，以及支原体属等。