1-(正丁基)-3-(4-氟苯基)苯并[f]喹啉 | 1055314-50-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 1-(正丁基)-3-(4-氟苯基)苯并[f]喹啉
• 英文名称: 1-(n-butyl)-3-(4-fluorophenyl)benzo[f]quinoline
• 英文别名: 1-Butyl-3-(4-fluorophenyl)benzo[f]quinoline
• CAS: 1055314-50-5
• 化学式: C₂₃H₂₀FN
• 分子量: 329.417
• InChiKey: BQSXXBPKUYGYEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-己酮 、 对氟苯甲醛 、 2-萘胺 在 碘 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 以88%的产率得到1-(正丁基)-3-(4-氟苯基)苯并[f]喹啉
  参考文献：
  名称：

  碘催化三组分反应合成3-芳基苯并喹啉衍生物的高效高选择性方法

  摘要：

  介绍了一种以碘为催化剂，通过芳醛、萘-2-胺和酮或β-酮酯的三组分反应合成苯并[F]喹啉衍生物的温和、高效和高选择性的方法。It should be noted that only one product was obtained, with high selectivity, when ketones or β-keto esters with two different α-hydrogen atoms were chosen as reactants.

  DOI：

  10.1055/s-2008-1067087

文献信息

• An Efficient and Highly Selective Method for the Synthesis of 3-Arylbenzo­quinoline Derivatives Catalyzed by Iodine via Three-Component Reactions
  作者：Xiang-Shan Wang、Qing Li、Jian-Rong Wu、Yu-Ling Li、Chang-Sheng Yao、Shu-Jiang Tu

  DOI：10.1055/s-2008-1067087

  日期：——

  A mild, efficient and highly selective method for the synthesis of benzo[ F]quinoline derivatives via three-component reactions of arylaldehydes, naphthalen-2-amine and ketones or β-keto esters using iodine as catalyst is described. It should be noted that only one product was obtained, with high selectivity, when ketones or β-keto esters with two different α-hydrogen atoms were chosen as reactants

  介绍了一种以碘为催化剂，通过芳醛、萘-2-胺和酮或β-酮酯的三组分反应合成苯并[F]喹啉衍生物的温和、高效和高选择性的方法。It should be noted that only one product was obtained, with high selectivity, when ketones or β-keto esters with two different α-hydrogen atoms were chosen as reactants.