椴树酸 | 465-01-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 椴树酸
• 中文别名: 吡咯烷,2-(2-甲氧基-3-甲基-2-丁烯-1-基)-2-苯基-
• 英文名称: bassic acid
• 英文别名: (4aS,6aS,6aS,6bR,9R,10R,11S,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,10,11,12,13,14b-dodecahydropicene-4a-carboxylic acid
• CAS: 465-01-0
• 化学式: C₃₀H₄₆O₅
• 分子量: 486.692
• InChiKey: FJGGNIPUSLFYJJ-QJTVMKANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  35
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  椴树酸 在 乙醇 、 铜 、 铂 作用下， 生成 3ξ-hydroxy-2-oxo-24-nor-5ξ-oleanen-(12)-oic acid-(28)-methyl ester
  参考文献：
  名称：

  133.皂苷元。第九部分 贝酸的发生与构成

  摘要：

  DOI：

  10.1039/jr9400000713
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 作用下， 生成 椴树酸
  参考文献：
  名称：

  King et al., Journal of the Chemical Society, 1955, p. 1338,1340

  摘要：

  DOI：

文献信息

• Novel migrated oleanane triterpenoid sapogenins from mimusops elengi
  作者：Sucharita Sen、Niranjan P. Sahu、Shashi B. Mahato

  DOI：10.1016/s0040-4020(01)91220-7

  日期：1993.1

  Two new pentacyclic triterpene acids, mimusopic acid (3) and mimusopsic acid (5) possessing the novel migrated oleanane skeleton, mimusopane were isolated.

  分离出具有新的迁移的齐墩果骨架的mimusopane的两个新的五环三萜酸，mimusopic酸（3）和mimusopsic酸（5）。
• ACCELERATOR FOR INITIAL INSULIN SECRETION
  申请人：Use-Techno Corporation

  公开号：EP1674089A1

  公开（公告）日：2006-06-28

  The present invention provides an early insulin secretion stimulator consisting of a triterpene represented by the following general formula (1) and/or a triterpene represented by the following general formula (2). [where R1 represents COOH, etc., R11 and R12 represent CH2OH, etc., X1 represents hydrogen or OH and X11, X12, X21 and X22 represent OH, etc.]

  本发明提供了一种早期胰岛素分泌刺激剂，由以下通式（1）代表的三萜和/或以下通式（2）代表的三萜组成。 [其中 R1 代表 COOH 等，R11 和 R12 代表 CH2OH 等，X1 代表氢或 OH，X11、X12、X21 和 X22 代表 OH 等。］
• Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof
  申请人：SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.

  公开号：US10301303B2

  公开（公告）日：2019-05-28

  The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders. The compounds and pharmaceutical compositions of the invention can be utilized to treat various diseases or disorders, such as diabetes, diabetic complications, dyslipidemia, hyperlipidemia, obesity, metabolic syndromes, pre-diabetes, atherosclerosis, heart diseases, neurodegenerative diseases, sarcopenia, muscle atrophy, inflammation, cancer and liver diseases and conditions such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. The compounds of this invention are also useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.

  本发明提供了小檗碱与药理活性有机酸结合的各种新型组合物及其用于治疗各种疾病或失调的相关方法。本发明进一步提供了由小檗碱和药理活性有机酸制备的和由熊去氧胆酸和药理活性有机碱制备的各种新型化合物及其药物组合物，以及它们在治疗和/或预防各种疾病或紊乱中的制备和治疗方法。本发明的化合物和药物组合物可用于治疗各种疾病或失调，如糖尿病、糖尿病并发症、血脂异常、高脂血症、肥胖症、代谢综合征、糖尿病前期、动脉粥样硬化、心脏病、神经退行性疾病、骨质疏松症等、神经退行性疾病、肌肉疏松症、肌肉萎缩、炎症、癌症和肝脏疾病，如脂肪肝、非酒精性脂肪肝、非酒精性脂肪性肝炎、胆汁淤积性肝病或肝脏移植物抗宿主疾病。本发明的化合物还可用于改善慢性病毒相关性肝病和酒精相关性肝病的肝功能。
• Pharmaceutical composition comprising berberine ursodeoxycholic acid salt for the treatment of various diseases or disorders
  申请人：SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.

  公开号：US10988471B2

  公开（公告）日：2021-04-27

  The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders. The compounds and pharmaceutical compositions of the invention can be utilized to treat various diseases or disorders, such as diabetes, diabetic complications, dyslipidemia, hyperlipidemia, obesity, metabolic syndromes, pre-diabetes, atherosclerosis, heart diseases, neurodegenerative diseases, sarcopenia, muscle atrophy, inflammation, cancer and liver diseases and conditions such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. The compounds of this invention are also useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.

  本发明提供了小檗碱与药理活性有机酸结合的各种新型组合物及其用于治疗各种疾病或失调的相关方法。本发明进一步提供了由小檗碱和药理活性有机酸制备的和由熊去氧胆酸和药理活性有机碱制备的各种新型化合物及其药物组合物，以及它们在治疗和/或预防各种疾病或紊乱中的制备和治疗方法。本发明的化合物和药物组合物可用于治疗各种疾病或失调，如糖尿病、糖尿病并发症、血脂异常、高脂血症、肥胖症、代谢综合征、糖尿病前期、动脉粥样硬化、心脏病、神经退行性疾病、骨质疏松症等、神经退行性疾病、肌肉疏松症、肌肉萎缩、炎症、癌症和肝脏疾病，如脂肪肝、非酒精性脂肪肝、非酒精性脂肪性肝炎、胆汁淤积性肝病或肝脏移植物抗宿主疾病。本发明的化合物还可用于改善慢性病毒相关性肝病和酒精相关性肝病的肝功能。
• Plant extracts
  申请人：Hansen Kaae Ole

  公开号：US20050233016A1

  公开（公告）日：2005-10-20

  The invention relates to a method for preparing an saponin-containing aqueous extract on the basis of a waste product from a butter tree of the Sapotaceae family, said method comprising the following steps: (i) mixing one part waste product with 4-30 parts of water; (ii) incubating the mixture formed in step (i) under alkaline conditions; and (iii) recovering an aqueous extract containing saponins by removing solids from the alkaline mixture formed in step (ii). The invention also relates to saponin-containing aqueous extracts obtainable by said method and uses thereof.

  本发明涉及一种以山榄科黄油树的废品为基础制备含皂苷水提取物的方法，该方法包括以下步骤：(i) 将一份废品与 4-30 份水混合；(ii) 在碱性条件下培养步骤 (i) 中形成的混合物；(iii) 从步骤 (ii) 中形成的碱性混合物中去除固体，回收含皂苷水提取物。本发明还涉及通过上述方法获得的含皂苷的水提取物及其用途。