1-[2-(2-氯乙氧基)乙氧基]丁烷 | 1120-23-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-[2-(2-氯乙氧基)乙氧基]丁烷
• 英文名称: 1-[2-(2-chloroethoxy)-ethoxy]butane
• 英文别名: 1-[2-(2-chloro-ethoxy)-ethoxy]-butane；1-butoxy-2-(2-chloro-ethoxy)ethane；Aethylenglykol-(2-chlor-aethylaether)-butylaether；1-Butoxy-2-(2-chlor-aethoxy)aethan；1-[2-(2-Chloroethoxy)ethoxy]butane
• CAS: 1120-23-6
• 化学式: C₈H₁₇ClO₂
• 分子量: 180.675
• InChiKey: DZWMJKOIMKFXIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2909199090

反应信息

• 作为反应物：
  描述：

  1-[2-(2-氯乙氧基)乙氧基]丁烷 在 bis-triphenylphosphine-palladium(II) chloride 、 palladium dichloride 甲醇 、 copper(l) iodide 、 potassium carbonate 、 三乙胺 、 三苯基膦 、 potassium iodide 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 12.0h， 生成 2-[2-[4-[2-(2-Butoxyethoxy)ethoxy]phenyl]ethynyl]-8-[2-[8-[2-[8-[2-[4-[2-(2-butoxyethoxy)ethoxy]phenyl]ethynyl]-5,5-dioxodibenzothiophen-2-yl]ethynyl]dibenzothiophen-2-yl]ethynyl]dibenzothiophene 5,5-dioxide
  参考文献：
  名称：

  Synthesis and Structure-Linear and Structure-Nonlinear Optical Properties of Multi-Dipolar Zigzag Oligoaryleneethynylenes

  摘要：

  A novel series of monodisperse, multi-dipolar zigzag oligoaryleneethynylenes DA(n) and D-Ar-A(n), bearing electron-donating dibenzothiophene and electron-accepting dibenzothiophene dioxide as arenes, with up to six charge-transfer (dipolar) units have been designed and synthesized by palladium-catalyzed Sonogashira coupling reactions. The linear and nonlinear optical properties of these multi-dipolar oligoaryleneethynylenes can easily be modified or enhanced by incorporating/extending with various central aryleneethynyl moieties such as phenylethynyl, oligo(9,9-dibutylfluorenyl)ethynyl, and oligothienylethynyl within the donor-acceptor units. Interestingly, the absorption and emission of these zigzag oligoaryleneethynylenes are not dependent on the number of covalently linked dipolar chromophores; however, the fluorescence quantum efficiencies consistently decrease with increased number of covalently linked dipolar units. These zigzag oligoaryleneethynylenes exhibit a linear increase in the two-photon absorption (TPA) cross-sections with increased number of covalently linked dipolar units without red-shifting the absorption and emission spectra. In addition, very large TPA cross-sections in the femtosecond regime (sigma(800) = 1306 GM in DMF or sigma(750) = 1522 GM in CH2Cl2) were obtained for D-TF-A(4) despite the moderate strength of the donor-acceptor pair. Our results suggest that the TPA properties of these zigzag oligoaryleneethynylenes including TPA wavelength and TPA cross-section can easily be tuned by means of modifying the central aryleneethynylene units and increasing the number of dipolar units, respectively. This approach provides an alternative means to tune or enhance the TPA cross-section at a specific wavelength.

  DOI：

  10.1021/jo070607z
• 作为产物：
  描述：

  二乙二醇丁醚 在 吡啶 、 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 10.0h， 以95%的产率得到1-[2-(2-氯乙氧基)乙氧基]丁烷
  参考文献：
  名称：

  Rhodamine-labelled new architecture for dual sensing of Co2+ and Hg2+ ions

  摘要：

  A new rhodamine-based chemosensor 1 has been designed and synthesized. The receptor selectively recognizes Co2+ and Hg2+ in CH3CN/water (4:1, v/v; 10 mu M tris HCl buffer, pH 6.8) by showing different extents of change in emission. The disappearance of colour of mercury-ensemble of 1 followed by appearance of distinct bluish colour under UV illumination upon addition of L-cysteine distinguishes Hg2+ from Co2+ ions. The receptor shows in vitro detection of both the ions in human cervical cancer (HeLa) cells. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.09.062

文献信息

• Chain-length dependent conformational behaviour of triblock oligomers α-octyl-ω-n-alkoxytetrakis(oxyethylene)s in the solid state studied by Raman spectroscopy
  作者：Koichi fukuhara、Sei Masatoki、Takeshi Yonemitsu、Hiroatsu Matsuura

  DOI：10.1016/s0022-2860(97)00317-7

  日期：1998.3

  Abstract The Raman spectra of triblock oligomers α-octyl-ω-n-alkoxytetrakis(oxyethylene)s, H(CH2)8(OCH2CH2)4O(CH2)nH with n = 2–7, were measured in the solid state, and the conformational behaviour with changing alkyl chain length was examined. The molecular conformations of these compounds were determined by spectral analysis based on normal coordinate calculations. The conformation changes from the

  摘要 三嵌段低聚物 α-辛基-ω-n-烷氧基四(氧乙烯)s, H(CH2)8(O )4O( )nH（n = 2-7）的拉曼光谱是在固态下测量的，并且检查了改变烷基链长度的构象行为。这些化合物的分子构象是通过基于法向坐标计算的光谱分析确定的。随着烷基链长度 (n) 的增加，构象从延伸/螺旋/延伸形式变为完全延伸形式。氧乙烯链的延伸结构稳定在 n ≥ 3。该实验发现表明，三嵌段化合物中氧乙烯嵌段的延伸结构由长度与氧乙烯嵌段相当或更长的末端烷基嵌段稳定. 这项研究的结果，
• Biosynthesis of Penicillins. VII.¹ Oxy- and Mercaptoacetic Acids
  作者：Quentin F. Soper、Calvert W. Whitehead、Otto K. Behrens、Joseph J. Corse、Reuben G. Jones

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  日期：1948.9
• Devakumar, C.; Saxena, V. S.; Mukerjee, S. K., Agricultural and Biological Chemistry, 1985, vol. 49, # 3, p. 725 - 730
  作者：Devakumar, C.、Saxena, V. S.、Mukerjee, S. K.

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  日期：——
• Genetics of Fracture: Challenges and Opportunities
  作者：Tuan V. Nguyen、John A. Eisman

  DOI：10.1359/jbmr.2000.15.7.1253

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• Acid Amides as Hypnotics. III. Disubstituted Acetamides
  作者：F. F. Blicke、M. F. Zienty

  DOI：10.1021/ja01855a081

  日期：1941.10