1-十二基-5-氧代吡咯烷-3-羧酸 | 10054-21-4

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-十二基-5-氧代吡咯烷-3-羧酸
• 中文别名: N-十二烷基-5-羰基吡咯烷-3-甲酸；1-十二烷基-5-氧代吡咯烷-3-羧酸
• 英文名称: 1-Lauryl-4-carboxy-2-pyrrolidone
• 英文别名: 1-dodecyl-5-oxo-pyrrolidine-3-carboxylic acid；1-Dodecyl-5-oxo-pyrrolidin-3-carbonsaeure；1-Dodecyl-5-oxopyrrolidine-3-carboxylic acid
• CAS: 10054-21-4
• 化学式: C₁₇H₃₁NO₃
• 分子量: 297.438
• InChiKey: ZNQTZHTYSHEJLH-UHFFFAOYSA-N

物化性质

• 熔点：
  39℃
• 沸点：
  463.5±38.0 °C(Predicted)
• 密度：
  1.021±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933790090

反应信息

• 作为反应物：
  描述：

  1-十二基-5-氧代吡咯烷-3-羧酸 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 二环[2.2.1]庚-2,5-二烯-7-醇
  参考文献：
  名称：

  CN116425663

  摘要：

  公开号：
• 作为产物：
  描述：

  十二烷基伯胺 、 衣康酸 在 乙腈 作用下， 生成 1-十二基-5-氧代吡咯烷-3-羧酸
  参考文献：
  名称：

  N-higher alkyl-4-carboxy-2-pyrrolidones and compositions therewith

  摘要：

  公开号：

  US02757125A1

文献信息

• COMBINATION PEPTIDE-NANOPARTICLES AND DELIVERY SYSTEMS INCORPORATING SAME
  申请人：Midatech Limited

  公开号：US20150099698A1

  公开（公告）日：2015-04-09

  Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.

  纳米颗粒具有核心和与核心共价连接的配体环，其中不同种类的肽与纳米颗粒结合，并纳入各种剂型中。
• TRPV1 agonist compounds and methods for making and using the same
  申请人：Jamieson Curtis Gene

  公开号：US20060240097A1

  公开（公告）日：2006-10-26

  Described here are TRPV1 agonist compounds and their methods of synthesis and use. In addition to specifically identified compounds, capsaicin prodrugs, gemini dimers, and mutual prodrugs are also described. Formulations of the TRPV1 agonist compounds may be in the form of a liquid, tablets, capsules, gel, cream, emulsion, a patch, or the like. Methods for treating medical conditions using the compounds, compositions, or prodrugs described, are also provided.

  这里描述了TRPV1激动剂化合物及其合成和使用方法。除了具体识别的化合物外，还描述了辣椒素前药、双子星二聚体和相互前药。TRPV1激动剂化合物的配方可以是液体、片剂、胶囊、凝胶、乳霜、乳状液、贴片等形式。还提供了使用所述化合物、组合物或前药治疗医疗状况的方法。
• COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONTAINING A MEROCYANINE DERIVATIVE COMPRISING SPECIFIC POLAR GROUPS CONSISTING OF HYDROXYL- AND ETHER-FUNCTIONALITIES
  申请人：Richard Herve

  公开号：US20140294743A1

  公开（公告）日：2014-10-02

  The present invention relates to a cosmetic and/or dermatological composition comprising in a physiologically acceptable medium at least one merocyanine derivative of formula (1) or (2) and/or its E,E-, E,Z- or Z,Z-geometrical isomer forms: comprising specific polar groups consisting of hydroxyl- and ether-functionalities. Another object of the present invention relates to a cosmetic process for controlling and/or improving the darkening of the skin under exposure to UV radiation and the homogeneity of the colour of the complexion which comprises the application onto the skin of a cosmetic composition as above defined. Another object of the present invention relates to a cosmetic process for protecting the keratinic materials and particularly the skin against photo-ageing which comprises the application onto the keratinic material of a cosmetic composition as above defined.

  本发明涉及一种化妆品和/或皮肤科学组合物，其在生理上可接受的介质中包含至少一种公式（1）或（2）的merocyanine衍生物及/或其E，E-，E，Z-或Z，Z-几何异构体形式：包括由羟基和醚功能团组成的特定极性基团。本发明的另一个目的涉及一种化妆过程，用于控制和/或改善皮肤在紫外线照射下的变黑和肤色均匀性，包括在皮肤上涂抹上述定义的化妆品组合物。本发明的另一个目的涉及一种化妆过程，用于保护角质素材料，特别是皮肤免受光老化的影响，包括在角质素材料上涂抹上述定义的化妆品组合物。
• [EN] USE OF CANNABIDIOL PRODRUGS IN TOPICAL AND TRANSDERMAL ADMINISTRATION WITH MICRONEEDLES<br/>[FR] UTILISATION DE PROMÉDICAMENTS DE CANNABIDIOL POUR ADMINISTRATION TOPIQUE ET TRANSDERMIQUE AVEC DES MICRO-AIGUILLES
  申请人：ALLTRANZ INC

  公开号：WO2011026144A1

  公开（公告）日：2011-03-03

  Described herein are microneedle drug delivery systems comprising a pharmaceutical compositions comprising pharmaceutically active agents (e.g., cannabidiol and prodrugs of cannabidiol) and microneedle arrays suitable for local and systemic delivery of the active agent to a mammal. Also described herein are methods of using a microneedle transdermal or topical drug delivery systems comprising pharmaceutical compositions, comprising cannabidiol and prodrugs of cannabidiol, and microneedle arrays in the treatment disease, including pancreatitis and pancreatic cancer.

  本文描述了微针药物递送系统，包括含有药物活性成分（例如大麻二酚和大麻二酚前药）的药物组合物和适用于将活性成分局部或全身性递送至哺乳动物的微针阵列。本文还描述了使用微针经皮或局部药物递送系统治疗疾病，包括胰腺炎和胰腺癌的方法，其中药物组合物包括大麻二酚和大麻二酚前药，并且使用微针阵列。
• Compositions and methods for treatment of premature ejaculation
  申请人：NexMed (Holdings) Inc.

  公开号：US20040241245A1

  公开（公告）日：2004-12-02

  Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C 1 to C 8 alcohol, an aliphatic C 8 to C 30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.

  提供了治疗早泄的组合物和方法，其中包括一种含有局部麻醉剂、剪切稀释聚合物增稠剂、选择自脂肪族C1到C8醇、脂肪族C8到C30酯、液态多元醇或其混合物的亲脂成分、水和缓冲系统的组合物，该缓冲系统为组合物提供了在约3至约7.4范围内的缓冲pH值，并将其用于阴茎尿道口。