氢碘酸三乙醇胺 | 7601-53-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 氢碘酸三乙醇胺
• 中文别名: 氢碘酸TEA盐
• 英文名称: tris(2-hydroxyethyl)amine hydroiodide
• 英文别名: triethanolammonium iodide；tris-(2-hydroxy-ethyl)-amine; hydriodide；Tris-(2-hydroxy-aethyl)-amin; Hydrojodid；2,2',2''-nitrilotrisethanol hydroiodide；triethanolamine hydroiodide；Tris(2-hydroxyethyl)ammonium iodide；tris(2-hydroxyethyl)azanium;iodide
• CAS: 7601-53-8
• 化学式: C₆H₁₆NO₃*I
• 分子量: 277.102
• InChiKey: AHJXIGQHVVYEGR-UHFFFAOYSA-N

物化性质

• 熔点：
  168 °C
• LogP：
  -1.108 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.88
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.9
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 安全说明：
  S24/25

SDS

Name:	Triethanolamine hydroiodide 99% Material Safety Data Sheet
Synonym:
CAS:	7601-53-8

Section 1 - Chemical Product MSDS Name:Triethanolamine hydroiodide 99% Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7601-53-8	Triethanolamine hydroiodide	99	231-508-2

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Hygroscopic (absorbs moisture from the air).The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 7601-53-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: C6H15NO3.HI
Molecular Weight: 277.09

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture, strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen, hydrogen iodide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7601-53-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Triethanolamine hydroiodide - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 7601-53-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 7601-53-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7601-53-8 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  氢碘酸三乙醇胺 、 碘化锑 以 二甲基亚砜 为溶剂， 以92%的产率得到[triethanolammonium]4[Sb4I16]
  参考文献：
  名称：

  Synthesis and structure of antimony complexes [Ph3AmP] 2 + [Sb2I8 · 2DMSO]2−, [Ph3PrP] 2 + [Sb2I8 · C4H8O2]2−, and [(HOCH2CH2)3NH] 4 + [Sb4I16]4−

  摘要：

  The reaction of equimolar amounts of triphenylamyl- and triphenylpropylphosphonium iodides and triethanolammonium iodide with antimony iodide in dimethyl sulfoxide, dioxane, or acetone gave complexes [Ph3AmP] (2) (+) [Sb2I8 center dot 2DMSO](2-), [Ph3PrP] (2) (+) [Sb2I8 center dot C4H8O2](2-), and [(HOCH2CH2)(3)NH] (4) (+) [Sb4I16](4-), the structure of which was established by X-ray diffraction analysis. The cations of all complexes have slightly distorted tetrahedral structure, and the antimony atoms in the anions are hexacoordinated. The crystals of the complexes have intra- and intermolecular contacts, which form the structure.

  DOI：

  10.1134/s0036023611020264
• 作为产物：
  描述：

  三乙醇胺 在 氢碘酸 作用下， 以 水 为溶剂， 生成 氢碘酸三乙醇胺
  参考文献：
  名称：

  PROCESS FOR THE PREPARATION OF ALKYLENE CARBONATE

  摘要：

  一种用于制备烷基碳酸酯的方法，该方法包括在水和催化组分的存在下，将相应的烷基氧化物与二氧化碳接触，所述催化组分包括用氢卤酸中和的有机碱，其中有机碱包括含有至少一个自由电子对的一种或多种氮原子的碳基化合物和/或含有至少一个自由电子对的一种或多种磷原子的碳基化合物，并且有机碱的pKa值大于8。

  公开号：

  US20080071096A1
• 作为试剂：
  描述：

  环氧乙烷 、 二氧化碳 在 氢碘酸三乙醇胺 作用下， 以 水 为溶剂， 80.0 ℃ 、2.0 MPa 条件下， 反应 1.0h， 生成 碳酸乙烯酯
  参考文献：
  名称：

  PROCESS FOR THE PREPARATION OF ALKYLENE CARBONATE

  摘要：

  一种用于制备烷基碳酸酯的方法，该方法包括在水和催化组分的存在下，将相应的烷基氧化物与二氧化碳接触，所述催化组分包括用氢卤酸中和的有机碱，其中有机碱包括含有至少一个自由电子对的一种或多种氮原子的碳基化合物和/或含有至少一个自由电子对的一种或多种磷原子的碳基化合物，并且有机碱的pKa值大于8。

  公开号：

  US20080071096A1

文献信息

• [EN] COMPOUNDS USEFUL FOR THE TREATMENT AND/OR CARE OF THE SKIN, HAIR, NAILS AND/OR MUCOUS MEMBRANES<br/>[FR] COMPOSÉS UTILES DANS LE TRAITEMENT ET/OU LE SOIN DE LA PEAU, DES CHEVEUX, DES ONGLES ET/OU DES MUQUEUSES
  申请人：LUBRIZOL ADVANCED MAT INC

  公开号：WO2018071640A1

  公开（公告）日：2018-04-19

  The invention relates to a peptide of formula (I) R1-Wm-Xn-AA1-AA2-AA3-Yp-Zq-R2, cosmetic or pharmaceutical compositions comprising same and its use, for example, in the reduction of lipid accumulation in the skin, the treatment of cellulite and/or the treatment of the symptoms of skin aging.

  该发明涉及一种肽，其化学式为(I) R1-Wm-Xn-AA1-AA2-AA3-Yp-Zq-R2，包括相同肽的化妆品或药用组合物以及其用途，例如在减少皮肤脂质积聚、治疗橘皮组织和/或治疗皮肤老化症状中的应用。
• Reagenz für die coulometrische Wasserbestimmung
  申请人：RIEDEL-DE HAEN AKTIENGESELLSCHAFT

  公开号：EP0384195A2

  公开（公告）日：1990-08-29

  Reagenz für die coulometrische Wasserbestimmung in einer diaphragmalosen Zelle, bestehend aus einem alkoholischen Lösungsmittel oder Lösungsmittelgemisch, in dem Imidazol und/oder ein Imidazolderivat und/oder Diethanolamin und/oder Trithanolamin und Schwefeldioxid und ein Iodid oder mehrere Iodide und gegebenenfalls ein Leitsalz oder mehrere Leitsalze gelöst sind.

  用于在无隔膜样品池中用库仑法测定水含量的试剂，由溶有咪唑和/或咪唑衍生物和/或二乙醇胺和/或三乙醇胺、二氧化硫、一种或多种碘化物以及可选的一种或多种导电盐的醇类溶剂或溶剂混合物组成。
• Production process of cross-linked polyaspartic acid resin
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0866084A2

  公开（公告）日：1998-09-23

  A process is disclosed for producing with good productivity a cross-linked polyaspartic acid resin having biodegradability and high water absorbency. The process features inclusion of one of the following steps: (a) a polysuccinimide, which has been brought into a dispersed state by a dispersant, and a cross-linking agent are reacted to produce the cross-linked polyaspartic acid resin; (b) imide rings of a cross-linked polysuccinimide are subjected to a hydrolysis reaction while controlling a swelling degree of a resulting gel, whereby the cross-linked polyaspartic acid resin is produced; and (c) a gel of a cross-linked polysuccinimide, which has been obtained by reacting a cross-linking agent to a solution of a polysuccinimide in an organic solvent, is disintegrated to subject imide rings of the cross-linked polysuccinimide to a hydrolysis reaction, so that the cross-linked polyaspartic acid resin is produced. The process may also include one or both of the following steps as needed: (d) a gel of the cross-linked polyaspartic acid resin is washed with water and/or a water-miscible organic solvent; and (e) the polysuccinimide is produced using a basic amino acid as a cross-linking agent.

  本发明公开了一种工艺，用于生产具有生物降解性和高吸水性的交联聚天冬氨酸树脂，生产效率高。该工艺的特点是包含以下步骤之一：(a) 通过分散剂使聚琥珀酰亚胺进入分散状态，并与交联剂反应，生成交联聚天冬氨酸树脂；(b) 将交联聚琥珀酰亚胺的酰亚胺环进行水解反应，同时控制所得凝胶的溶胀度，从而生成交联聚天冬氨酸树脂；(c) 将交联剂与聚琥珀酰亚胺在有机溶剂中的溶液反应而得到的交联聚琥珀酰亚胺凝胶分解，使交联聚琥珀酰亚胺的酰亚胺环发生水解反应，从而制得交联聚天冬氨酸树脂。根据需要，该工艺还可包括以下一个或两个步骤：(d) 用水和/或水混溶有机溶剂洗涤交联聚天冬氨酸树脂的凝胶；(e) 使用碱性氨基酸作为交联剂生产聚琥珀酰亚胺。
• COMPOSITION FOR THE PREVENTION AND TREATMENT OF CELLULITIS
  申请人：LIPOTEC, S.A.

  公开号：EP1611898A1

  公开（公告）日：2006-01-04

  The invention relates to a composition for preventing and treating cellulite, characterized in that it comprises ingredients with lipolytic and venotonic effects, preferably a mixture of caffeine, dry butcher's broom extract (Ruscus Aculeatus), triethanolamine hydroiodide, ivy extract (Hedera helix), L-carnitine and amorphous escine, the tripeptide glycyl-histidyl-lysine, cosmetically acceptable carriers and excipients and water.

  本发明涉及一种用于预防和治疗脂肪团的组合物，其特征在于它包含具有脂肪分解和静脉舒张作用的成分，最好是咖啡因、干屠帚提取物（Ruscus Aculeatus）、三乙醇胺氢碘酸盐、常春藤提取物（Hedera helix）、左旋肉碱和无定形 escine、甘氨酰-组氨酰-赖氨酸三肽、化妆品可接受的载体和赋形剂以及水的混合物。
• Expolysaccharide for the treatment and/or care of skin, culture media and compositions thereof
  申请人：Lipotec, S.A.

  公开号：EP2868308A1

  公开（公告）日：2015-05-06

  Exopolysaccharide of a bacterial strain for its use in treatment and/or care of the skin, as well as its cosmetic and/or dermopharmaceutical compositions. In particular, its use for inflammation, lipolysis, lipid accumulation and skin firmness.

  用于治疗和/或护理皮肤的细菌菌株外多糖及其化妆品和/或皮肤药物组合物。特别是用于炎症、脂肪分解、脂质堆积和皮肤紧致。