12-脱氧佛波醇13-当归酸酯20-乙酸酯 | 25090-72-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 12-脱氧佛波醇13-当归酸酯20-乙酸酯
• 英文名称: 12-Deoxyphorbol-13-tiglate-20-acetate
• 英文别名: [(1R,2S,6R,10S,11R,13S,15R)-8-(acetyloxymethyl)-1,6-dihydroxy-4,12,12,15-tetramethyl-5-oxo-13-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] (E)-2-methylbut-2-enoate
• CAS: 25090-72-6
• 化学式: C₂₇H₃₆O₇
• 分子量: 472.6
• InChiKey: ZZTJICHINNSOQL-LWYYLCCUSA-N

物化性质

• 沸点：
  493.35°C (rough estimate)
• 密度：
  1.1248 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Compositions and methods of use of phorbol esters for the treatment of stroke
  申请人：Biosuccess Biotech Co. Ltd.

  公开号：US10010519B2

  公开（公告）日：2018-07-03

  Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.

  本发明提供了含有植物醇酯或植物醇酯衍生物的方法和组合物，用于治疗和预防中风及中风后遗症。此外，还提供了其他组合物和方法，这些组合物和方法采用了与至少一种额外制剂相结合的植物醇酯或衍生物化合物，以产生更有效的治疗工具来治疗或预防哺乳动物中风和中风的长期后遗症。
• Compositions and methods of use of phorbol esters in the treatment of neoplasms
  申请人：Biosuccess Biotech Co. Ltd.

  公开号：US10278934B2

  公开（公告）日：2019-05-07

  Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease. The phorbol esters described are particularly useful in the treatment of neoplastic diseases and/or managing the side effects of chemotherapeutic and radiotherapeutic treatments of neoplastic diseases.

  本发明提供了含有植物醇酯或植物醇酯衍生物的方法和组合物，用于治疗慢性和急性疾病。这些病症可能由疾病引起，也可能是疾病的症状、治疗方法或后遗症。所述的植物醇酯特别适用于治疗肿瘤性疾病和/或控制肿瘤性疾病化疗和放疗的副作用。
• COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTER IN THE TREATMENT OF NEOPLASMS
  申请人：Biosuccess Biotech Co. Ltd.

  公开号：US20180214409A1

  公开（公告）日：2018-08-02

  Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease. The phorbol esters described are particularly useful in the treatment of neoplastic diseases and/or managing the side effects of chemotherapeutic and radiotherapeutic treatments of neoplastic diseases.
• COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTERS IN THE TREATMENT OF NEOPLASMS
  申请人：Biosuccess Biotech Co. Ltd.

  公开号：US20190002390A1

  公开（公告）日：2019-01-03

  Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease. The phorbol esters described are particularly useful in the treatment of neoplastic diseases and/or managing the side effects of chemotherapeutic and radiotherapeutic treatments of neoplastic diseases.
• US9974764B2
  申请人：——

  公开号：US9974764B2

  公开（公告）日：2018-05-22