2,2,2-三氟-1-(1H-吡咯-3-基)-1-乙酮 | 130408-89-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,2,2-三氟-1-(1H-吡咯-3-基)-1-乙酮
• 英文名称: 3-(trifluoroacetyl)pyrrole
• 英文别名: 2,2,2-trifluoro-1-(1H-pyrrol-3-yl)ethanone
• CAS: 130408-89-8
• 化学式: C₆H₄F₃NO
• mdl: MFCD12924726
• 分子量: 163.099
• InChiKey: RJDXBZJGMUWDDH-UHFFFAOYSA-N

物化性质

• 熔点：
  108-110 °C
• 沸点：
  203.6±35.0 °C(Predicted)
• 密度：
  1.409±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2,2,2-三氟-1-(1H-吡咯-3-基)-1-乙酮 、 1-benzyl-2-vinylaziridine 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 (1R,2R)-(+)-1,2-二氨基环己烷-N,N′-双(2-苯基膦-1-萘酰基) 作用下， 以 1,2-二氯乙烷 为溶剂， 以95%的产率得到(S)-1-(1-(1-(benzylamino)but-3-en-2-yl)-1H-pyrrol-3-yl)-2,2,2-trifluoroethanone
  参考文献：
  名称：

  含氮杂环的乙烯基氮丙啶的钯催化动态动力学不对称转化：快速获得生物活性吡咯和吲哚

  摘要：

  我们报告说，氮杂环可以在钯催化的乙烯基氮丙啶动态动力学不对称烷基化中作为有能力的亲核试剂。得到的烷基化产物具有高区域选择性、化学选择性和对映选择性。取代的 1H-吡咯和 1H-吲哚都被成功地用于得到支化的 N-烷基化产物。通过将该方法应用于制备几种药物化学先导化合物和溴吡咯生物碱，包括 longamide B、longamide B 甲酯、hanishin、agesamides A 和 B 以及环碘酮，证明了该方法的合成效用。

  DOI：

  10.1021/ja1071509
• 作为产物：
  描述：

  3-(trifluoroacetyl)-1-(triisopropylsilyl)pyrrole 在 四丁基氟化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 以67%的产率得到2,2,2-三氟-1-(1H-吡咯-3-基)-1-乙酮
  参考文献：
  名称：

  N-(Triisopropylsilyl)pyrrole. A progenitor "par excellence" of 3-substituted pyrroles

  摘要：

  A very effective strategy has been devised for the synthesis of 3-substituted pyrroles based on the use of the triisopropylsilyl (TIPS) moiety as a sterically demanding nitrogen substituent to obstruct the attack of electrophilic reagents at the alpha-positions. 1-(Triisopropylsilyl)pyrrole (1) undergoes highly preferential kinetic electrophilic substitution at the beta-position with a variety of electrophiles (Br+, I+, NO2+, RCO+, etc.) and fluoride ion induced desilylation of the products provides the corresponding 3-substituted pyrroles in good overall yields. Competitive trifluoroacetylation experiments demonstrate that substitution of TIPS-pyrrole at the alpha-positions is decelerated by a factor of > 10(4), vs pyrrole at the same sites, without affecting reactivity at the beta-positions. 1-(Triisopropylsilyl)-3-bromopyrrole (2) is readily converted into the 3-lithio compound 44 by bromine-lithium interchange with alkyllithium reagents. This previously unavailable, formal equivalent of 3-lithiopyrrole is itself an excellent source of a wide range of beta-substituted pyrroles, many of which would not be directly preparable from 1. TIPS-pyrrole can be 3,4-dihalogenated and these compounds undergo sequential halogen-metal interchange trapping reactions. This process is exemplified by an efficient, three-step synthesis of the antibiotic verrucarin E (63) from the dibromo compound 5.

  DOI：

  10.1021/jo00313a019

文献信息

• Convenient One-Pot Synthesis of N-Substituted 3-Trifluoroacetyl Pyrroles
  作者：Nilo Zanatta、Ana Wouters、Leonardo Fantinel、Fabio da Silva、Rosemário Barichello、Pedro da Silva、Daniela Ramos、Helio Bonacorso、Marcos Martins

  DOI：10.1055/s-0028-1087821

  日期：——

  A new one-pot strategy for the synthesis of a series of new N-substituted 3-trifluoroacetyl pyrroles is presented. These compounds were obtained by the reaction of 3-trifluoroacetyl-4,5-dihydrofuran with primary amines, which generated 1,1,1-trifluoro-3-(2-hydroxyethyl)-4-alkylaminobut-3-en-2-one intermediates. In most cases these intermediates were not stable enough to be isolated. Thus, in the same

  提出了一种新的一锅法合成一系列新的 N-取代 3-三氟乙酰基吡咯。这些化合物是通过 3-三氟乙酰基-4,5-二氢呋喃与伯胺反应得到的，反应生成 1,1,1-三氟-3-(2-羟乙基)-4-烷基氨基丁-3-en-2-one中间体。在大多数情况下，这些中间体不够稳定，无法分离。因此，在同一反应容器中，它们直接被 PCC（科里试剂）氧化以提供 1,1,1-三氟-3-(2-乙醛)-4-烷基氨基丁-3-en-2-ones，其中在回流下进行分子内环化，以中等产率得到所需的 N-取代 3-三氟乙酰基吡咯。
• Mixed-Metal MIL-100(Sc,M) (M=Al, Cr, Fe) for Lewis Acid Catalysis and Tandem CC Bond Formation and Alcohol Oxidation
  作者：Laura Mitchell、Patrick Williamson、Barbora Ehrlichová、Amanda E. Anderson、Valerie R. Seymour、Sharon E. Ashbrook、Nadia Acerbi、Luke M. Daniels、Richard I. Walton、Matthew L. Clarke、Paul A. Wright

  DOI：10.1002/chem.201404377

  日期：2014.12.15

  obtained and filtered off after extended reaction times. Supported α‐Fe2O3 nanoparticles were also active Lewis acid species, although less active than Sc3+ in trimer sites. The incorporation of Fe3+ into MIL‐100(Sc) imparts activity for oxidation catalysis and tandem catalytic processes (Lewis acid+oxidation) that make use of both catalytically active framework Sc3+ and Fe3+. A procedure for using these mixed‐metal

  通过直接合成将三价金属阳离子Al 3+，Cr 3+和Fe 3+以及Sc 3+分别引入MIL-100（Sc，M）固溶体（M = Al，Cr，Fe）中。粉末X射线衍射（PXRD）和固态NMR，UV / Vis和X射线吸收（XAS）光谱已证实了该取代。混合SC /是在铁的哪个部分制备的Fe MIL-100样品呈现为的α-Fe 2 ö 3如XAS，TGA和PXRD所示，MOF介孔笼中的纳米颗粒。路易斯酸催化的Friedel-Crafts添加物中的混合金属催化剂的催化活性随Sc含量的增加而增加，第二种金属的衰减作用按Al> Fe> Cr的顺序降低。Sc，Fe混合金属材料具有可接受的活性：在相同的反应时间内掺入40％的铁只会导致活性降低20％，并且在延长的反应时间后仍可得到纯净的产品并过滤掉。支持的α-Fe 2个ö 3纳米颗粒也活性的路易斯酸物种，比钪虽然较不活跃3+中的三聚体的网站。Fe 3+的结合
• A new synthetic route to 3-polyfluoroalkyl-containing pyrroles
  作者：Elena N. Shaitanova、Igor I. Gerus、Valery P. Kukhar

  DOI：10.1016/j.tetlet.2007.12.048

  日期：2008.2

  A novel approach to 3-polyfluoroalkyl pyrroles is reported based on step by step reactions: 1,2-addition of Me3SiCN to β-alkoxyvinyl polyfluoroalkyl ketones, reduction with LiAlH4 and subsequent hydrolysis with intramolecular cyclization. The hydrolytic instability of various polyfluoroalkyl groups at position 3 of the pyrrole ring was evident and a pathway for the hydrolysis was proposed.

  据报导一种基于逐步反应的3-多氟烷基吡咯的新颖方法：将Me 3 SiCN 1，2-加成至β-烷氧基乙烯基多氟烷基酮，用LiAlH 4还原并随后通过分子内环化进行水解。在吡咯环的3位上的各种多氟烷基的水解不稳定性是明显的，并提出了水解的途径。
• Synthesis of CF3-bearing pyrrolidines by hydrogenation of trifluoroacetylated pyrrole derivatives
  作者：Radomyr V. Smaliy、Aleksandra A. Chaykovskaya、Nataliya A. Shtil、Sergey A. Yurchenko、Aleksandr A. Yurchenko、Aleksandr I. Lakhtadyr、Alina O. Gorlova、Aleksandr N. Kostyuk

  DOI：10.1016/j.jfluchem.2015.09.017

  日期：2015.12

  Trifluoroacylated pyrroles and related compounds can be transformed to CF3-bearing pyrrolidines via a Pd/C-mediated hydrogenation under acidic conditions in high yields. The synthesis of several compounds of this type was considerably simplified as compared to formerly available procedures. Stereochemical aspects of the hydrogenation were studied and methods for both preparation and separation of diastereomerically

  三氟酰化的吡咯和相关化合物可以在酸性条件下通过Pd / C介导的氢化以高收率转化为带有CF 3的吡咯烷。与以前可用的方法相比，这种类型的几种化合物的合成大大简化了。研究了氢化的立体化学方面，并开发了制备和分离非对映异构纯产物的方法。
• Okada, Etsuji; Masuda, Ryoichi; Hojo, Masaru, Heterocycles, 1992, vol. 34, # 7, p. 1435 - 1441
  作者：Okada, Etsuji、Masuda, Ryoichi、Hojo, Masaru、Yoshida, Reiko

  DOI：——

  日期：——