2,2,4-三甲基戊烷-1,4-二醇 | 80864-10-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,2,4-三甲基戊烷-1,4-二醇
• 英文名称: 2,2,4-trimethylpentane-1,4-diol
• 英文别名: 2,2,4-Trimethyl-pentan-1,4-diol
• CAS: 80864-10-4
• 化学式: C₈H₁₈O₂
• 分子量: 146.23
• InChiKey: UPQBAPMBTTWGMM-UHFFFAOYSA-N

物化性质

• 熔点：
  86°C
• 沸点：
  243.79°C (rough estimate)
• 密度：
  0.9636 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,4-三甲基戊烷-1,4-二醇 在 硫酸 作用下， 生成 2,2,4,4-四甲基四氢呋喃
  参考文献：
  名称：

  Mossler, Monatshefte fur Chemie, 1903, vol. 24, p. 599,607, 609

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2,4-三甲基-1,3-戊二醇 在 氢溴酸 、 silver(I) acetate 、 溶剂黄146 作用下， 生成 2,2,4-三甲基戊烷-1,4-二醇
  参考文献：
  名称：

  Mossler, Monatshefte fur Chemie, 1903, vol. 24, p. 599,607, 609

  摘要：

  DOI：

文献信息

• Direct Synthesis of 1,4-Diols from Alkenes by Iron-Catalyzed Aerobic Hydration and CH Hydroxylation
  作者：Takuma Hashimoto、Daisuke Hirose、Tsuyoshi Taniguchi

  DOI：10.1002/anie.201308675

  日期：2014.3.3

  Various 1,4‐diols are easily accessible from alkenes through iron‐catalyzed aerobic hydration. The reaction system consists of a user‐friendly iron phthalocyanine complex, sodium borohydride, and molecular oxygen. Furthermore, the effect of additional ligands on the iron complex was examined for a model reaction. The second hydroxy group is installed by direct C(sp3)H oxygenation, which is based on

  通过铁催化的需氧水合很容易从烯烃中获得各种1,4-二醇。该反应系统由用户友好的酞菁铁络合物，硼氢化钠和分子氧组成。此外，针对模型反应检查了其他配体对铁络合物的影响。第二个羟基是通过直接C（sp 3）H氧合而安装的，这是基于烯烃的正式水合形成的瞬态烷氧基的[1,5]氢转移过程。
• 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle
  申请人：Sekiguchi Yoshinori

  公开号：US20080318923A1

  公开（公告）日：2008-12-25

  It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

  旨在提供一种对与精氨酸加压素V1b受体相关的病理状况具有疗效的药物。更具体地说，旨在提供一种对抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、消化系统疾病、药物成瘾、癫痫、脑梗死、脑缺血、脑水肿、头部损伤、炎症、免疫疾病、脱发等具有治疗或预防作用的药物。经过深入研究，发现了一种新颖的1,3-二氢-2H-吲哚-2-酮化合物和与杂芳环融合的吡咯烷-2-酮化合物，它们是高度选择性的精氨酸加压素V1b受体拮抗剂，具有高代谢稳定性，表现出有利的血脑屏障穿透和高血浆浓度，从而实现了上述目标。
• Concentrated, stable, preferably clear, fabric softening composition
  申请人：Trinh Toan

  公开号：US20060058216A1

  公开（公告）日：2006-03-16

  Principal solvents, especially mono-ol and diol principal solvents, having a ClogP of from about 0.15 to about 0.64, preferably from about 0.25 to about 0.62, and more preferably from about 0.40 to about 0.60, are disclosed that have the ability to make clear aqueous fabric softener compositions containing relatively high concentrations of fabric softener actives having ester linkages in their long, hydrophobic chains. The fabric softener actives are either unsaturated, or have intermediate length chains (˜C 12-14 ) and the said principal solvents are used at levels of less than about 40%. Other solvents may be present. Some of the said principal solvents are novel compounds and/or novel mixtures. Premixes of the fabric softening actives, the principal solvents, and, optionally, other solvents are useful in the preparation of complete formulations by obviating/limiting the need for heating.

  本发明揭示了主要溶剂，特别是具有ClogP约为0.15至约0.64，优选为约0.25至约0.62，更优选为约0.40至约0.60的单醇和双醇主要溶剂，具有制备含有长链疏水基中酯键的相对高浓度织物柔顺剂活性成分的清澈水性织物柔顺剂组合物的能力。织物柔顺剂活性成分可以是不饱和的，也可以具有中等长度的链（约C12-14），所述主要溶剂的使用水平小于约40％。其他溶剂可以存在。其中一些主要溶剂是新化合物和/或新混合物。织物柔顺剂活性成分、主要溶剂和可选的其他溶剂的预混物在制备完整配方时是有用的，因为它们可以避免/限制加热的需要。
• Branched amides of L-aspartyl-D-amino acid dipeptides and compositions thereof
  申请人：PFIZER INC.

  公开号：EP0034876A2

  公开（公告）日：1981-09-02

  Amides of L-aspartyl-D-amino acid dipeptides of the formula and physiologically acceptable cationic and acid addition salts thereof wherein Ra is methyl, ethyl, n-propyl or isopropyl and R is a branched aliphatic, alicyclic or heterocyclic member which is branched at the alpha carbon atom (the carbon atom bearing the amide nitrogen atom) and also branched again at one or both of the beta carbon atoms, are potent sweeteners which are free from undesirable flavour qualities and of high stability in conventional food processing. Sweetening compositions and sweetened edible compositions of such amides are also claimed

  式中 L-天冬氨酰-D-氨基酸二肽的酰胺类 及其生理上可接受的阳离子盐和酸加成盐，其中 Ra 为甲基、乙基、正丙基或异丙基，R 为支链脂环族、脂环族或杂环族成员，该成员在 α 碳原子（含酰胺氮原子的碳原子）上有支链，在一个或两个β碳原子上也有支链。这种酰胺的甜味组合物和甜味可食用组合物也已申请专利。
• Colored resin composition
  申请人：MITSUBISHI PETROCHEMICAL CO., LTD.

  公开号：EP0188200A2

  公开（公告）日：1986-07-23

  A colored resin composition characterized in that it has a matrix of a thermoplastic polymer (A), typically a polyester, and a thermoplastic polymer (B), typically a styrene polymer, which is dispersed in the matrix and is separated in phase from the matrix, and the polymer (B) is filled with substantially the entire quantity of a colorant. Since the colorant is blended in only the dispersed phase polymer (B), deterioration due to the colorant of various characteristics, such as bleed-out of the colorant, is prevented in the colored resin composition according to this invention.

  一种有色树脂组合物，其特征在于它具有由热塑性聚合物（A）（通常为聚酯）和热塑性聚合物（B）（通常为苯乙烯聚合物）组成的基体，热塑性聚合物（A）分散在基体中，并与基体相分离，聚合物（B）中填充了基本上全部数量的着色剂。 由于着色剂只混合在分散相聚合物（B）中，因此根据本发明的有色树脂组合物可以防止着色剂引起的各种特性的劣化，例如着色剂的渗出。