1-(4-Propan-2-ylphenyl)pentane-2,4-dione

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(4-Propan-2-ylphenyl)pentane-2,4-dione
• 英文别名: 1-(4-propan-2-ylphenyl)pentane-2,4-dione
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.29
• InChiKey: VESYYHNTVQIZGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES
  申请人：PFIZER INC.

  公开号：US20210308276A1

  公开（公告）日：2021-10-07

  The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R 1 , R 2 , Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone-based conjugation handles.