N',N'-dimethyl-4-propan-2-ylbenzohydrazide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N',N'-dimethyl-4-propan-2-ylbenzohydrazide
• 化学式: C₁₂H₁₈N₂O
• 分子量: 206.28
• InChiKey: ARHRNXLEYSFZCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND
  申请人：Nakamura Takanori

  公开号：US20100310536A1

  公开（公告）日：2010-12-09

  An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
• US7253158B2
  申请人：——

  公开号：US7253158B2

  公开（公告）日：2007-08-07