2,3-二甲基咪唑氯化物 | 34531-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2,3-二甲基咪唑氯化物
• 英文名称: 2,3-dimethylimidazolium chloride
• 英文别名: 1,2-dimethylimidazolium chloride；1,2-Dimethylimidazolium chloride, 98%；1,2-dimethyl-1H-imidazol-1-ium;chloride
• CAS: 34531-53-8
• 化学式: C₅H₈N₂*ClH
• 分子量: 132.593
• InChiKey: PIVSXYQVNSKDFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.15
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  17.8
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  对二甲苯 、 2,3-二甲基咪唑氯化物 以 乙腈 为溶剂， 生成 phenylenebis(methylene)bis(1,2-dimethyl-1H-imidazol-3-ium) dichloride
  参考文献：
  名称：

  The subtle effect of methyl substituent in C2-symmetric template on the formation of halocluster hybrids

  摘要：

  Six novel haloclusters, namely {[dmb](2)[Cu4I8]}center dot 2DMF (1), {[ddb][Cu4I6]}(n) (2), {[dmb][Ag2I4]}(n) (3), {[ddb][Ag4I6]}(n) (4), {[dmb](2)[Ag2Br6]} (5) and {[ddb][Ag4Br6]}(n) (6), were encountered in our investigation of the subtle template effect of methyl substituent on the formation of hybrids. The dications we chosen as C-2-symmetric template is alpha,alpha'-di(3-methylimidozole-1-yl)benzene dichloride (abbreviated into dmb) or alpha,alpha'-di(2,3-dimethylimidozole-1-yl)benzene dichloride (abbreviated into ddb). The X-ray crystallography shows the more methyl substituents that exist in template, the more inorganic/organic interactions form in the hybrid net oriented by ddb. It is the H-bonds and electrostatic interactions between the organic counteractions and inorganic moieties that do the contribution to the crystal packing. These compounds have been further characterized by IR spectroscopy, UV-Vis spectra and thermostability properties. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.09.029
• 作为产物：
  描述：

  1,2-dimethyl-3-(4-methylphenyl)sulfonyl-1,2-dihydroimidazol-1-ium,chloride 、 2-胺基乙酸乙酯 在 盐酸 、 四甲基氯化铵 作用下， 以 乙醇 为溶剂， 生成 N-Ts-甘氨酸乙酯 、 2,3-二甲基咪唑氯化物
  参考文献：
  名称：

  Monjoint, P.; Ruasse, M. F., Bulletin de la Societe Chimique de France, 1988, # 2, p. 356 - 360

  摘要：

  DOI：
• 作为试剂：
  描述：

  甲醇 、 一氧化碳 在 2,3-二甲基咪唑氯化物 、 氯化(1-丁基-3-甲基咪唑) 、 copper(l) chloride 氧气 作用下， 120.0 ℃ 、2.45 MPa 条件下， 反应 1.0h， 以28.9%的产率得到碳酸二甲酯
  参考文献：
  名称：

  Method for preparing organic carbonates

  摘要：

  一种制备有机碳酸酯的方法，包括将醇化合物在一液相催化系统中与一氧气和一液态催化剂一起进行氧化羰基化反应，从而形成有机碳酸酯，其中所述液相催化系统包括至少一种催化剂、至少一种添加剂和至少一种由含氮杂环结构的阳离子和一阴离子组成的离子液体。通过使用添加剂和离子液体，增强了催化剂的活性和性能，可以获得增加的反应速率和产率。

  公开号：

  US20080300419A1

文献信息

• [EN] EP4 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES AUX RECEPTEURS EP4
  申请人：PHARMAGENE LAB LTD

  公开号：WO2004067524A1

  公开（公告）日：2004-08-12

  Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either -(CH2)n-X-, where n is 1 or 2 and X is O, S, S(=O), S(=O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is -C(=O)NRN2-, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either:(i) carboxy;(ii) a group of formula (II); or(iii) a group of formula (III):, wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl;(iv) tetrazol-5-yl.

  式(I)的化合物：其中：R2为H或可选择地取代的C1-4烷基基团；Y为-(CH2)n-X-，其中n为1或2，X为O、S、S(=O)、S(=O)2或NRN1，其中RN1从H或可选择地取代的C1-4烷基中选择，或Y为-C(=O)NRN2-，其中RN2从H、可选择地取代的C1-7烷基或C5-20芳基中选择；R3为可选择地取代的C6芳基基团，连接到另一个可选择地取代的C6芳基基团，如果两个C6芳基基团均为苯环，则两个环之间可能有氧桥，在两个环上的连接处相邻结合；A为单键或C1-3烷基基团；R5为以下之一：(i)羧基；(ii)式(II)的基团；或(iii)式(III)的基团：其中R为可选择地取代的C1-7烷基、C5-20芳基或NRN3RN4，其中RN3和RN4独立地从可选择地取代的C1-4烷基中选择；(iv)四唑-5-基。
• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF PREGABALIN<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE PRÉGABALINE
  申请人：HIKAL LTD

  公开号：WO2021105742A1

  公开（公告）日：2021-06-03

  The present invention relates to an improved process for the preparation of Pregabalin (I), which is simple, economical, efficient, and environment friendly, commercially viable with chemical and chiral purity at least 99.95%.

  本发明涉及一种改进的制备盐酸普拉巴林（I）的方法，该方法简单、经济、高效、环保，具有至少99.95%的化学和手性纯度，具有商业可行性。
• [EN] CHLORINATION OF SUCROSE-6-ESTERS<br/>[FR] CHLORATION DES 6-ESTERS DE SACCHAROSE
  申请人：TATE & LYLE TECHNOLOGY LTD

  公开号：WO2015092374A1

  公开（公告）日：2015-06-25

  There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford a mixture; (iv) heating said mixture for a heating period in order to provide chlorination of sucrose- 6-acylate at the 4, 1' and 6' positions thereof; (v) quenching said mixture to produce a 4,1',6'-trichloro-4,1',6'-trideoxy- galactosucrose-6-acylate; wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; and wherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises perfluorooctane.

  提供了一种氯化蔗糖-6-酰酸酯制备4,1',6'-三氯-4,1',6'-去氧半乳糖蔗糖-6-酰酸酯的方法，该方法包括以下步骤（i）至（v）：（i）提供含有蔗糖-6-酰酸酯的第一组分；（ii）提供含有氯化剂的第二组分；（iii）将所述第一组分和所述第二组分结合以得到混合物；（iv）加热所述混合物一段加热时间以在其4、1'和6'位置上氯化蔗糖-6-酰酸酯；（v）淬灭所述混合物以产生4,1',6'-三氯-4,1',6'-去氧半乳糖蔗糖-6-酰酸酯；其中，所述第一组分和/或所述第二组分中至少一种含有反应载体，所述反应载体包括三级酰胺；并且所述混合物在步骤（iv）的至少一部分加热时间内包括共溶剂，所述共溶剂包括全氟辛烷。
• Method for Separating Hydrogen Chloride and Phosgene
  申请人：Wolfert Andreas

  公开号：US20070293707A1

  公开（公告）日：2007-12-20

  The invention relates to a process for separating hydrogen chloride and phosgene, which comprises bringing a mixture of hydrogen chloride and phosgene into contact with an ionic liquid in which at least part of the hydrogen chloride is dissolved in a step a) and then separating off the hydrogen chloride dissolved in the ionic liquid in a step b).

  本发明涉及一种分离氯化氢和光气的方法，包括将氯化氢和光气的混合物在离子液体中接触，其中至少部分氯化氢在步骤a）中溶解，然后在步骤b）中分离出溶解在离子液体中的氯化氢。
• Indole derivatives
  申请人：GLAXO GROUP LIMITED

  公开号：EP0266899A2

  公开（公告）日：1988-05-11

  The invention relates to compounds of formula (I) wherein R¹ represents a hydrogen atom or a group selected from C1-10 alkyl, C3-6 alkenyl, C3-10 alkynyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-4 alkyl, phenyl, or phenyl C1-3alkyl, -CO₂R¹⁰, -COR¹⁰, -CONR¹⁰R¹¹ or -SO₂R¹⁰ (wherein R¹⁰ and R¹¹, which may be the same or different , each represents a hydrogen atom, a C1-6 alkyl or C3-7 cycloalkyl group, or a phenyl or phenylC1-4 alkyl group, in which the phenyl group is optionally substituted by one or more C1-4 alkyl, C1-4 alkoxy or hydroxy groups or halogen atoms, with the proviso that R¹⁰ does not represent a hydrogen atom when R¹ represents a group -CO₂R¹⁰ or -SO₂R¹⁰); R₂ represents a hydrogen atom or a C1-6 alkyl, C3-6 alkenyl, C3-7 cycloalkyl, phenyl or phenyl C1-3 alkyl group; R₃ and R₄, which may be the same of different, each represents a hydrogen atom or a C1-6 alkyl group; One of the groups represented by R⁵, R⁶ and R⁷ is a hydrogen atom or a C1-6 alkyl, C1-6 hydroxyalkyl, C3-7 cycloalkyl, C2-6 alkenyl, phenyl or phenyl C1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and Q represents a hydrogen or a halogen atom, or a hydroxy, C1-4 alkoxy, phenyl C1-3 alkoxy or C1-6 alkyl group or a group -NR⁸R⁹ or -CONR⁸R⁹ wherein R⁸ and R⁹, which may be the same or different, each represents a hydrogen atom or a C1-4 alkyl or C3-4 alkenyl group, or together with the nitrogen atom to which they are attached form a saturated 5 to 7 membered ring; and physiologically acceptable salts and solvates thereof. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT₃ receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.

  本发明涉及式 (I) 的化合物 其中 R¹ 代表氢原子或选自 C1-10 烷基、C3-6 烯基、C3-10 炔基、C3-7 环烷基、C3-7 环烷基 C1-4 烷基、苯基或苯基 C1-3 烷基、-CO₂R¹⁰、-COR¹⁰、-CONR¹⁰R¹¹ 或-SO₂R¹⁰（其中 R¹⁰ 和 R¹¹可以相同或不同，各自代表一个氢原子、C1-6烷基或C3-7环烷基，或苯基或苯基C1-4烷基，其中苯基任选被一个或多个C1-4烷基、C1-4烷氧基或羟基或卤素原子取代，但当R¹代表基团-CO₂R¹⁰或-SO₂R¹⁰时，R¹₂不代表氢原子）； R₂ 代表氢原子或 C1-6 烷基、C3-6 烯基、C3-7 环烷基、苯基或苯基 C1-3 烷基； R₃ 和 R₄ 可以相同或不同，各自代表氢原子或 C1-6 烷基； R⁵、R⁶ 和 R⁷ 所代表的基团之一是氢原子或 C1-6 烷基、C1-6 羟烷基、C3-7 环烷基、C2-6 烯基、苯基或苯基 C1-3 烷基，另外两个基团（可以相同或不同）各自代表氢原子或 C1-6 烷基；以及 Q 代表氢原子或卤素原子，或羟基、C1-4 烷氧基、苯基 C1-3 烷氧基或 C1-6 烷基，或基团 -NR⁸R⁹ 或 -CONR⁸R⁹ 其中 R⁸ 和 R⁹ 可以相同或不同，各自代表氢原子或 C1-4 烷基或 C3-4 烯基，或与所连接的氮原子一起形成饱和的 5-7 分子环； 及其生理上可接受的盐和溶剂。 这些化合物是 5-HT 在 5-HT₃ 受体上的强效选择性拮抗剂，可用于治疗精神障碍、焦虑、恶心和呕吐等疾病。