2,4-二(1,1-二甲基乙基)喹啉 | 78324-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2,4-二(1,1-二甲基乙基)喹啉
• 英文名称: 2,4-bis(1,1-dimethylethyl)quinoline
• 英文别名: 2,4-Di-tert-butylquinoline；2,4-Di-tert-butylchinolin；2,4-Ditert-butylquinoline
• CAS: 78324-96-6
• 化学式: C₁₇H₂₃N
• 分子量: 241.376
• InChiKey: MUPWAMPDUPXEFN-UHFFFAOYSA-N

物化性质

• 沸点：
  316.2±11.0 °C(Predicted)
• 密度：
  0.964±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,2-二甲基丙酸苯酯 在 苯胺 、 zinc(II) chloride 盐酸 、 sodium amide 、 苯胺 作用下， 以 苯 为溶剂， 反应 45.0h， 生成 2,4-二(1,1-二甲基乙基)喹啉
  参考文献：
  名称：

  Knorr, Rudolf; Weiss, Alfons, Chemische Berichte, 1981, vol. 114, # 6, p. 2104 - 2115

  摘要：

  DOI：

文献信息

• Radical generation enabled by photoinduced N–O bond fragmentation
  作者：Edward J. McClain、Alan K. Wortman、Corey R. J. Stephenson

  DOI：10.1039/d2sc02953g

  日期：——

  Recent advances in synthetic chemistry have seen a resurgence in the development of methods for visible light-mediated radical generation. Herein, we report the development of a photoactive ester based on a quinoline N-oxide core structure, that provides a strong oxidant in its excited state. The heteroaromatic N-oxide provides access to primary, secondary, and tertiary radical intermediates, and its

  合成化学的最新进展见证了可见光介导的自由基生成方法的重新开发。在此，我们报告了基于喹啉N-氧化物核心结构的光活性酯的开发，该酯在激发态下提供强氧化剂。杂芳族N-氧化物提供了获得伯、仲和叔自由基中间体的途径，并且报道了其在光化学 Minisci 烷基化开发中的应用。
• Russell, Glen A.; Rajaratnam, Rajine; Wang, Lijuan, Journal of the American Chemical Society, 1993, vol. 115, # 23, p. 10596 - 10604
  作者：Russell, Glen A.、Rajaratnam, Rajine、Wang, Lijuan、Shi, Bing Zhi、Kim, Byeong Hyu、Yao, Ching Fa

  DOI：——

  日期：——
• tert-Butylation of Quinolinium Cations and Quinoline N-Oxides by tert-Butylmercury Halides
  作者：Glen A. Russell、Lijuan Wang、Ching-Fa Yao

  DOI：10.1021/jo00122a013

  日期：1995.9

  In the presence of t-BuHgCl/KI the radical cations formed by the addition of tert-butyl radicals to C-2 of the quinolinium cation react in Me(2)SO by proton loss followed by one-electron oxidation (1a, R = H, Me, Cl). For the N-methyl, or N-methoxyquinolinium cations proton loss is not observed and the radical cations react by one-electron reduction (1b, R = Me, Cl; Ic, R = Me), With quinoline N-oxide and its 4-substituted derivatives the C-2 adduct radicals (1d, R = H, Me, Cl) are deprotonated by DABCO to yield after one-electron oxidation the 2-tert-butylquinoline N-oxides. The adduct radical cations formed by t-Bu(.) addition at the C-4 of quinolinium ions 2 seldom lose the C-4 proton but react by reduction, hydration, or in the case of 2-chloroquinoline N-oxide, dimerization. The loss of the proton from the 2-adducts 1 but not from the 4-adducts 2 seems to be stereoelectronic in origin. With N-methylquinolinium cation the addition of t-Bu(.) occurs selectively (>90%) at C-4 in contrast to the low selectivity observed in addition to quinolinium ion itself. However, with N-methoxyquinolinium perchlorate the major reaction products (70-90%) result from the addition of t-Bu(.) at C-2.
• SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US20210317114A1

  公开（公告）日：2021-10-14

  The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.