2,6-二氯苯甲酸钠 | 10007-84-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,6-二氯苯甲酸钠
• 英文名称: sodium 2,6-dichlorobenzoate
• 英文别名: sodium 2,6-dichloro-benzoate；sodium;2,6-dichlorobenzoate
• CAS: 10007-84-8
• 化学式: C₇H₃Cl₂O₂*Na
• 分子量: 212.995
• InChiKey: LZSRENODTOCXKJ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.64
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  2,6-二氯苯甲酸钠 在 硫酸 、 三(3,6-二氧杂庚基)胺 、 copper(l) chloride 作用下， 以 1,4-二氧六环 为溶剂， 生成 (8-Chloro-9-oxo-9H-xanthen-4-yl)-acetic acid
  参考文献：
  名称：

  Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo

  摘要：

  In a search for compounds related to flavoneacetic acid with activity against solid tumors, a series of methyl-, methoxy-, chloro-, nitro-, and hydroxy-substituted xanthenone-4-acetic acids have been synthesized and evaluated against subcutaneously implanted colon adenocarcinoma 38 in vivo, using a short-term histology assay as a primary screening system. A major goal of this work was to identify compounds with similar profiles of activity to that of flavoneacetic acid but of higher potency. The level of activity of the compounds appeared to depend more on the nature of the substituent than its positioning, in the order Cl greater than Me, OMe greater than NO2, OH. However, the potency of the compounds was related much more to the position rather than the nature of the substitution, with 5-substituted compounds being clearly the most dose potent. 5-Methylxanthenone-4-acetic acid has a similar level of activity to that of flavoneacetic acid in the test systems employed but is more than 7-fold as dose potent.

  DOI：

  10.1021/jm00124a012

文献信息

• [Bis(aryloxyacetoxy)iodo]benzenes
  作者：Ourania Menkisoglou-Spyroudi、Anastasios Varvoglis

  DOI：10.1039/p19860000795

  日期：——

  The title compounds (3) have been prepared and their chemical properties studied. With iodine they give aryloxymethyl aryloxyacetates (4) through the intermediacy of aryloxyacetyl hypoiodites and α-iodoanisoles. The former are unstable but have been trapped with pyridine to give N-iodopyridinium aryloxyacetates, whereas the latter are stable and react independently with compounds (3) to afford the

  已经制备了标题化合物（3）并研究了它们的化学性质。与碘一起，它们通过芳氧基乙酰基次碘酸盐和α-碘苯甲醚的中间体得到芳氧基甲基芳氧基乙酸酯（4）。前者是不稳定的，但已被吡啶截留，得到N-碘吡啶鎓的芳氧基乙酸盐，而后者是稳定的，并与化合物（3）独立反应，得到乙酸盐（4）。已经研究了（3）的热分解，并且除了酯（4）之外，还形成了芳基芳氧基乙酸酯。简要讨论了热分解的机理。
• METHOD FOR PRODUCING A RUTHENIUM COMPLEX
  申请人：Nara Hideki

  公开号：US20100076210A1

  公开（公告）日：2010-03-25

  Provided is a method for producing a ruthenium complex comprises the step of reacting a ruthenium compound represented by general formula (1): [RuX(L)(PP)]X   (1), wherein Ru represents a ruthenium atom; X represents a halogen atom; L represents an arene; and PP represents an optically active bisphosphine, with a carboxylate salt represented by general formula (2): R 1 CO 2 M   (2), wherein M represents a monovalent cation; and R 1 represents a group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups, to produce a ruthenium complex represented by general formula (3): Ru(OCOR 1 ) 2 (PP)   (3), wherein R 1 represents the group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups; and PP represents the optically active bisphosphine.

  提供的是一种制备钌配合物的方法，包括以下步骤：将由通式（1）表示的钌化合物与由通式（2）表示的羧酸盐反应，其中通式（1）为：[RuX(L)(PP)]X，其中Ru代表钌原子；X代表卤素原子；L代表芳烃；PP代表光学活性双膦；通式（2）为：R1CO2M，其中M代表一价阳离子；R1代表从烷基、卤代烷基、苯基（可选地带有取代基）、1-氨基烷基和1-氨基-1-苯基烷基组成的群中选择的基团，以制备由通式（3）表示的钌配合物：Ru(OCOR1)2(PP)，其中R1代表从烷基、卤代烷基、苯基（可选地带有取代基）、1-氨基烷基和1-氨基-1-苯基烷基组成的群中选择的基团；PP代表光学活性双膦。
• Method for producing a ruthenium complex
  申请人：Takasago International Corporation

  公开号：EP2166014A2

  公开（公告）日：2010-03-24

  Provided is a method for producing a ruthenium complex comprises the step of reacting a ruthenium compound represented by general formula (1):          [RuX(L)(PP)]X     (1), wherein Ru represents a ruthenium atom; X represents a halogen atom; L represents an arene; and PP represents an optically active bisphosphine, with a carboxylate salt represented by general formula (2):          R1CO2M     (2), wherein M represents a monovalent cation; and R1 represents a group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups, to produce a ruthenium complex represented by general formula (3) :          Ru(OCOR1)2(PP)     (3), wherein R1 represents the group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups; and PP represents the optically active bisphosphine.

  本发明提供了一种生产钌络合物的方法，包括使通式（1）代表的钌化合物发生反应的步骤： [RuX(L)(PP)]X (1)、 其中 Ru 代表钌原子；X 代表卤素原子；L 代表炔；PP 代表光学活性双膦、 与通式（2）所代表的羧酸盐： R1CO2M (2)、 其中 M 代表一价阳离子；R1 代表选自由烷基、卤代烷基、任选具有取代基的苯基、1-氨基烷基和 1-氨基-1-苯基烷基组成的基团、 生成通式 (3) 所代表的钌络合物： Ru(OCOR1)2(PP) (3)、 其中，R1 代表选自由烷基、卤代烷基、可选具有取代基的苯基、1-氨基烷基和 1-氨基-1-苯基烷基组成的组；PP 代表光学活性双膦。
• Garg, A. N.; Parwate, D. V.; Raj, D., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1987, vol. 26, # 4, p. 304 - 308
  作者：Garg, A. N.、Parwate, D. V.、Raj, D.

  DOI：——

  日期：——
• US7964744B2
  申请人：——

  公开号：US7964744B2

  公开（公告）日：2011-06-21