Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae)
摘要:
Monoterpenoids (3 and 4), sesquiterpenoid (2), diterpenoid (1) and four phenethyl glucosides (5-8), together with fourteen known compounds, were isolated from the whole herb of Hyssopus cuspidatus. Their structures were determined by spectroscopic means. The abietane-type diterpenoids (1, 9, 10), rosmarinic acid (15) and salvigenin (17) inhibited leukotriene (LT) C-4 secretion from primary alveolar cells of Wistar rats. (C) 2011 Elsevier Ltd. All rights reserved.
Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae)
摘要:
Monoterpenoids (3 and 4), sesquiterpenoid (2), diterpenoid (1) and four phenethyl glucosides (5-8), together with fourteen known compounds, were isolated from the whole herb of Hyssopus cuspidatus. Their structures were determined by spectroscopic means. The abietane-type diterpenoids (1, 9, 10), rosmarinic acid (15) and salvigenin (17) inhibited leukotriene (LT) C-4 secretion from primary alveolar cells of Wistar rats. (C) 2011 Elsevier Ltd. All rights reserved.
Rapid phenolic O-glycosylation of small molecules and complex unprotected peptides in aqueous solvent
作者:Tyler J. Wadzinski、Angela Steinauer、Liana Hie、Guillaume Pelletier、Alanna Schepartz、Scott J. Miller
DOI:10.1038/s41557-018-0041-8
日期:2018.6
Glycosylated natural products and synthetic glycopeptides represent a significant and growing source of biochemical probes and therapeutic agents. However, methods that enable the aqueous glycosylation of endogenous aminoacid functionality in peptides without the use of protecting groups are scarce. Here, we report a transformation that facilitates the efficient aqueous O-glycosylation of phenolic
Reinvestigation of the dried flowers of Jasminum polyanthum has led to the isolation of six new secoiridoid glucosides, jaspolyanoside, polyanoside, isojaspolyosides A, B and C, and 6"-O-β-D-glucopyranosyloleuropein, together with the known secoiridoid glucoside, angustifolioside B and flavonoid glycosides, nicotiflorine, kaempferol 3-O-(2-O-α-L-rhamnopyranosyl-β-D-galactopyranoside) and mauritianin. The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence. Comparison of the spectral data of 6"-O-β-D-glucopyranosyloleuropein and those reported for angustifolioside A, previously recognized as 6"-O-β-D-glucopyranosyloleuropein, led to the conclusion that the structure of angustifolioside A should be revised to 5"-O-β-D-glucopyranosyloleuropein.
对多花茉莉(Jasminum polyanthum)干花的重新研究导致分离出六种新的次生醇苷:茉莉苷(jaspolyanoside)、多花苷(polyanoside)、异茉莉苷 A、B 和 C,以及 6"-O-β-D-葡萄糖吡喃基橄榄苦苷(6"-O-β-D-glucopyranosyloleuropein),同时还分离出了已知的次生醇苷抗细弱苷 B(angustifolioside B)和黄酮苷,包括尼可苯吡啶(nicotiflorine)、山奈酚 3-O-(2-O-α-L-鼠李吡喃基-β-D-半乳糖吡喃苷)和毛里求斯苷(mauritianin)。新化合物的结构基于化学和光谱证据进行了阐明。对 6"-O-β-D-葡萄糖吡喃基橄榄苦苷的光谱数据与以前认定为 6"-O-β-D-葡萄糖吡喃基橄榄苦苷的抗细弱苷 A 进行比较,得出的结论是抗细弱苷 A 的结构应修订为 5"-O-β-D-葡萄糖吡喃基橄榄苦苷(5"-O-β-D-glucopyranosyloleuropein)。