2-(2-苯并呋喃基<氧茚基>)-5-苯基-1,3,4-噁二唑 | 88376-09-4

• 物质功能分类: 生物化工 - 氨基酸及其衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(2-苯并呋喃基&lt氧茚基&gt)-5-苯基-1,3,4-噁二唑
• 英文名称: 2-Methylleucine, hydrochlorid
• 英文别名: L-alpha-Methylleucine hy；(2S)-2-amino-2,4-dimethylpentanoic acid;hydrochloride
• CAS: 88376-09-4
• 化学式: C₇H₁₅NO₂*ClH
• 分子量: 181.663
• InChiKey: ZESCTDHOWCQMPQ-FJXQXJEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为产物：
  描述：

  2-[(2S)-2-甲氧基甲基-1-吡咯烷基亚甲基氨基]-4-甲基戊酸甲酯 在 盐酸 、 正丁基锂 、 二异丙胺 作用下， 反应 83.0h， 生成 2-(2-苯并呋喃基<氧茚基>)-5-苯基-1,3,4-噁二唑
  参考文献：
  名称：

  Kolb, Michael; Barth, Jacqueline, Liebigs Annalen der Chemie, 1983, # 10, p. 1668 - 1688

  摘要：

  DOI：

文献信息

• Selective enrichment of n-terminally modified peptides from complex samples
  申请人：Koninklijke Philips Electronics N.V.

  公开号：EP2108654A1

  公开（公告）日：2009-10-14

  The present invention relates to methods allowing selective enrichment of N-terminal fragments of polypeptides and/or peptides from complex samples by combining a particular polypcptidc/pcptidc labeling and fractionation strategy with specific chemical and/or enzymatic reactions targeting the N-terminal fragments to be analyzed

  本发明涉及通过将特定的多肽/多肽偶联体标记和分馏策略与针对待分析 N 端片段的特定化学和/或酶反应相结合，从复杂样品中选择性富集多肽和/或肽 N 端片段的方法。
• Compounds and methods for the labelling and affinity-selection of proteins
  申请人：Koninklijke Philips Electronics N.V.

  公开号：EP2108957A1

  公开（公告）日：2009-10-14

  The present invention relates to compounds and methods for the isotopic/isobaric labeling and the subsequent affinity selection and analysis of proteinaceous molecules. In particular, the invention relates to a labeling reagent for the labeling of proteinaceous molecules, comprising an isobaric label component, an isotopic label component, and a reactive group capable of reacting with a proteinaceous molecule, wherein the isotopic label component concomitantly is an affinity tag. The invention is also directed to a kit-of-parts comprising a combinatorial plurality of such labeling reagents as well as to a corresponding method for the analysis of proteinaceous molecules, the method comprising labeling at least one subset of the proteinaceous molecules present by employing a kit-of-parts as defined herein and subsequently separating the labeled molecules by affinity purification via the affinity tag comprised in the label. Finally, the invention relates to the uses of such methods for protein expression profiling or proteomic analyses.

  本发明涉及对蛋白质分子进行同位素/等位标记以及随后进行亲和性选择和分析的化合物和方法。特别是，本发明涉及一种用于标记蛋白质分子的标记试剂，它包括一个等位标记成分、一个同位素标记成分和一个能与蛋白质分子反应的反应基团，其中同位素标记成分同时也是一个亲和标记。本发明还涉及一种由多种此类标记试剂组合而成的试剂盒，以及一种用于分析蛋白质分子的相应方法，该方法包括通过使用本文定义的试剂盒对存在的蛋白质分子中的至少一个子集进行标记，然后通过标签中的亲和标签通过亲和纯化分离标记的分子。最后，本发明涉及将这种方法用于蛋白质表达谱分析或蛋白质组分析。
• COMPOUNDS AND METHODS FOR THE LABELING AND AFFINITY-SELECTION OF PROTEINS
  申请人：Koninklijke Philips Electronics N.V.

  公开号：EP2274621A2

  公开（公告）日：2011-01-19
• SELECTIVE ENRICHMENT OF N-TERMINALLY MODIFIED PEPTIDES FROM COMPLEX SAMPLES
  申请人：Koninklijke Philips Electronics N.V.

  公开号：EP2276777A2

  公开（公告）日：2011-01-26
• COMPOUNDS AND METHODS FOR THE LABELLING AND AFFINITY-SELECTION OF PROTEINS
  申请人：Hoffmann Ralf

  公开号：US20110028330A1

  公开（公告）日：2011-02-03

  The present invention relates to kits and methods for the isotopic/isobaric labeling and the subsequent affinity selection and analysis of proteinaceous molecules. In particular, the invention relates to a kit-of-parts comprising a combinatorial plurality of labeling reagent for the labeling of proteinaceous molecules, each labeling reagent comprising an isobaric label component, an isotopic label component, and a reactive group capable of reacting with a proteinaceous molecule, wherein the isotopic label component concomitantly is an affinity tag. The invention is also directed to a corresponding method for the analysis of proteinaceous molecules, comprising labeling at least one subset of the proteinaceous molecules present by employing a kit-of-parts as defined herein and subsequently separating the labeled molecules by affinity purification via the affinity tag comprised in the label. Finally, the invention relates to the uses of such methods for protein expression profiling or proteomic analyses.