1-chloro-3-ethoxypropan-2-one | 69378-63-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-chloro-3-ethoxypropan-2-one
• 英文别名: 1-chloro-3-ethoxypropanone；1-ethoxy-3-chloro-acetone；1-Aethoxy-3-chlor-aceton
• CAS: 69378-63-8
• 化学式: C₅H₉ClO₂
• mdl: MFCD16616568
• 分子量: 136.578
• InChiKey: GRKKNKUHYNPYKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-chloro-3-ethoxypropan-2-one 在 甲醇 、 potassium formate 作用下， 生成 1-ethoxy-3-hydroxypropan-2-one
  参考文献：
  名称：

  1-phenoxy-3-hydroxy-propanones-(2) and a process for their manufacture

  摘要：

  公开号：

  US02374283A1
• 作为产物：
  描述：

  1-氯-3-乙氧基-2-丙醇 在 铬 、 溶剂黄146 作用下， 生成 1-chloro-3-ethoxypropan-2-one
  参考文献：
  名称：

  1-phenoxy-3-hydroxy-propanones-(2) and a process for their manufacture

  摘要：

  公开号：

  US02374283A1

文献信息

• Supported NHC-Benzimi@Cu Complex as a Magnetically Separable and Reusable Catalyst for the Multicomponent and Click Synthesis of 1,4-Disubstituted 1,2,3-Triazoles via Huisgen 1,3-Dipolar Cycloaddition
  作者：Arvind Pawar、Shivanand Gajare、Ashutosh Jagdale、Sandip Patil、Wilson Chandane、Gajanan Rashinkar、Suresh Patil

  DOI：10.1007/s10562-021-03772-9

  日期：2022.6

  silica coated copper nano-magnetite NHC-benzimi@Cu complex as heterogeneous catalyst for the multicomponent click reaction via Huisgen 1,3-dipolar cycloaddition reaction of alkyl or aryl halide, sodium azide and terminal alkyne, which affords various1,4-disubstituted 1,2,3-triazoles. The multistep prepared nano catalyst has been characterized by various spectroscopic methods such as FT-IR, TGA, EDX, XRD

  在本文中，我们报道了一种新型磁性可分离二氧化硅包覆的铜纳米磁铁矿 NHC-benzimi@Cu 配合物作为多相催化剂，用于通过烷基或芳基卤化物、叠氮化钠和末端炔烃的 Huisgen 1,3-偶极环加成反应进行多组分点击反应。 ，得到各种1,4-二取代的1,2,3-三唑。多步制备的纳米催化剂已通过多种光谱方法如FT-IR、TGA、EDX、XRD、TEM和VSM进行了表征。涂覆在铜表面的非均相纳米催化剂结构是反应中优异催化剂性能的原因。从环境和经济的角度来看，催化剂的可重复使用性使本协议更加引人入胜。 图形摘要
• Pyridine derivatives as pesticides
  申请人：Novartis Corporation

  公开号：US05783704A1

  公开（公告）日：1998-07-21

  Compounds of formu (I) wherein n and Z are as defined in claim 1, and, where appropriate, tautomers thereof, in each case in free form, or in salt form, can be used as agrochemical active ingredients and can be prepared in a manner known per se.

  公式（I）的化合物，其中n和Z如权利要求1所定义的那样，并且在适当情况下，其互变异构体，每种情况下均以自由形式或盐形式存在，可以用作农药活性成分，并可以按照已知的方式制备。
• Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands
  申请人：Fukumoto Shoji

  公开号：US20090253687A1

  公开（公告）日：2009-10-08

  The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.

  本发明涉及其中每个符号如规范所定义的化合物，该化合物具有优越的矿物质皮质激素受体拮抗作用，可作为预防或治疗高血压、心力衰竭等药物，包括具有融合杂环的化合物、其前药或其盐；以及预防或治疗高血压、心力衰竭等疾病的药剂。
• Synthesis of magnetically separable catalyst Cu-ACP-Am-Fe3O4@SiO2 for Huisgen 1,3-dipolar cycloaddition
  作者：S.P. Vibhute、P.M. Mhaldar、S.N. Korade、D.S. Gaikwad、R.V. Shejawal、D.M. Pore

  DOI：10.1016/j.tetlet.2018.08.045

  日期：2018.10

  The present manuscript elicits the use of novel magnetically separable silica coated copper (Cu-ACP-Am-Fe3O4@SiO2) as a heterogeneous nanocatalyst for the Huisgen 1,3-dipolar cycloaddition reaction of alkyl or aryl halide, sodium azide and terminal alkyne, which provide a series of 1,4-disubstituted-1,2,3-triazoles. The catalyst was characterized by various physicochemical techniques such as Powder X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-Ray Spectroscopy(EDS), Thermogravimetric analysis (TGA-DSC), X-ray Photoelectron spectroscopy (XPS) and Vibrational sampling magnetometer (VSM). The acquisition of this nanocatalyst is also exemplified by employing reusability test and recycling of synthesized catalyst was achieved multiple times just by sequestering with an external magnet. It is noteworthy that the key-features like mild reaction conditions, simple work-up, High turnover number (TON), high turnover frequency (TOF), no use of hazardous organic solvents, easy recovery and reusability of the catalyst makes the present protocol more fascinating from an environmental and economic point of view. (C) 2018 Elsevier Ltd. All rights reserved.
• Dihydroxy-acetone-diether and its manufacture
  申请人：FIRM J R GEIGY A G

  公开号：US02349348A1

  公开（公告）日：1944-05-23