2-(4'-羟基苯氧基)-3-氯-5-三氟甲基吡啶 | 69045-89-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-(4'-羟基苯氧基)-3-氯-5-三氟甲基吡啶
• 英文名称: 2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine
• 英文别名: 4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenol；4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenol；3-chloro-2-p-hydroxyphenoxy-5-trifluoromethylpyridine；4-(3'-chloro-5'-trifluoromethyl-2'-pyridyloxy)phenol；4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)phenol；2-(4-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine；4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenol
• CAS: 69045-89-2
• 化学式: C₁₂H₇ClF₃NO₂
• 分子量: 289.641
• InChiKey: NMJNUBBLJFJUKE-UHFFFAOYSA-N

物化性质

• 沸点：
  331.4±42.0 °C(Predicted)
• 密度：
  1.469±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(4'-羟基苯氧基)-3-氯-5-三氟甲基吡啶 在 sodium hydroxide 、 potassium carbonate 作用下， 以 乙醇 、 水 、 二甲基亚砜 为溶剂， 生成 高效氟吡甲禾灵
  参考文献：
  名称：

  Substituted phenoxyalkanediones and their herbicidal method of use

  摘要：

  取代的苯氧基烷二酮及其中间体，以及所述化合物用于控制杂草的使用。

  公开号：

  US04522647A1
• 作为产物：
  描述：

  2,3-二氯-5-三氟甲基吡啶 以96.9%的产率得到2-(4'-羟基苯氧基)-3-氯-5-三氟甲基吡啶
  参考文献：
  名称：

  Process for producing 2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine

  摘要：

  本发明揭示了一种高效率生产2-(4′-羟基苯氧基)-3-氯-5-三氟甲基吡啶的方法，适用于工业规模生产。在本发明的方法中，将氢醌、0.10-0.70当量的脱卤代理以及极性无水溶剂和芳香烃溶剂混合。然后将混合物加热至大气压下的沸腾点以脱水。接着向混合物中添加0.20-0.95当量的2,3-二氯-5-三氟甲基吡啶作为脱卤代理，让混合物在100-170°C的温度下反应。

  公开号：

  EP0385720A3

文献信息

• [EN] SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE<br/>[FR] CARBAMATES DE PIPERIDINE A SUBSTITUTION UTILISES EN TANT QU'INHIBITEURS DE LA LIPASE HORMONOSENSIBLE
  申请人：NOVO NORDISK AS

  公开号：WO2004111032A1

  公开（公告）日：2004-12-23

  Novel substituted piperidine carbamates, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modulation of the activity of hormone sensitive lipase is beneficial.

  新型替代哌啶羰酸酯化合物，包括它们的药物组合物以及在治疗和/或预防与激素敏感性脂肪酶相关的疾病和紊乱中的应用。更具体地说，这些化合物对于治疗和/或预防需要调节激素敏感性脂肪酶活性的疾病和紊乱是有益的。
• Dihaloprene compound, insecticide/acaricide containing said
  申请人：Sumitomo Chemical Company, Limited

  公开号：US05530015A1

  公开（公告）日：1996-06-25

  There is disclosed a dihalopropene compound of the formula I: ##STR1## wherein l is an integer of 1 to 5; m is an integer of 1 to 4; R.sup.1 's and R.sup.2 's are the same or different and are independently halogen or various other groups; D is oxygen; X's are the same or different and are independently chlorine or bromine; Y is oxygen; Z, P and Q are the same or different and are independently nitrogen or CH, provided that P and Q are not simultaneously nitrogen, and when Y is sulfur, Z is CH. Also disclosed is an insecticide/acaricide comprising the dihalopropene compound as an active ingredient. The dihalopropene compound exhibits excellent insecticidal/acaricidal action. Further disclosed is an intermediate compound for use in the production of the dihalopropene compound.

  公开了一种具有以下结构的二卤代丙烯化合物：其中l为1到5的整数；m为1到4的整数；R^1和R^2相同或不同且独立地为卤素或其他各种基团；D为氧；X相同或不同且独立地为氯或溴；Y为氧；Z、P和Q相同或不同且独立地为氮或CH，但P和Q不能同时为氮，当Y为硫时，Z为CH。公开了一种含有上述二卤代丙烯化合物作为活性成分的杀虫剂/杀螨剂。该二卤代丙烯化合物表现出优异的杀虫/杀螨作用。还公开了用于生产上述二卤代丙烯化合物的中间体化合物。
• Process for producing
  申请人：Tosoh Corporation

  公开号：US05068336A1

  公开（公告）日：1991-11-26

  A process of producing 2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine with high efficiency, which is suited for industrial scale production is disclosed. In the process of the present invention, hydroquinone, a dehydrohalogenating agent in the amount of 0.10-0.70 equivalent of the hydroquinone, and a mixed solvent of a polar aprotic solvent and an aromatic hydrocarbon solvent are mixed. The resulting mixture is then heated to reflux at atmospheric pressure to dehydrate the mixture. Then 2,3-dichloro-5-trifluoromethylpyridine in the amount of 0.20-0.95 equivalent of the dehydrohalogenating agent is added to the mixture, and the resulting mixture is allowed to react at a temperature of 100.degree.-170.degree. C.

  本发明揭示了一种高效生产2-(4'-羟基苯氧基)-3-氯-5-三氟甲基吡啶的方法，适用于工业规模生产。在本发明的方法中，将氢醌、相当于氢醌的0.10-0.70当量的去卤代试剂以及极性无水溶剂和芳香烃溶剂的混合溶剂混合。然后将得到的混合物加热至大气压下回流以脱水。然后向混合物中添加相当于去卤代试剂的0.20-0.95当量的2,3-二氯-5-三氟甲基吡啶，并使得到的混合物在100°C至170°C的温度下反应。
• 2-Phenoxy-5-trifluoromethylpyridine compounds and process for
  申请人：Ishihara Sangyo Kaisha Ltd.

  公开号：US04152328A1

  公开（公告）日：1979-05-01

  A 2-phenoxy-5-trifluoromethylpyridine compound represented by the following general formula (I): ##STR1## wherein X represents a hydrogen atom or a chlorine atom, and R represents a hydrogen atom or a cation, and a process for the preparation thereof.

  由以下通用式（I）表示的2-苯氧基-5-三氟甲基吡啶化合物：其中X代表氢原子或氯原子，R代表氢原子或阳离子，以及其制备方法。
• ARYLOXY DIHALOPROPENYL ETHER COMPOUNDS AND USES THEREOF
  申请人：Liu Changling

  公开号：US20130303541A1

  公开（公告）日：2013-11-14

  The present invention discloses an aryloxy dihalopropenyl ether compound with the structure shown as general formula (I), of which the group definitions can be seen in the specification. The present invention also discloses the use of the compound with general formula (I) as an insecticide in the agricultural field and an insecticidal composition using the compound with general formula (I) as an active component.

  本发明揭示了一种具有通用式(I)所示结构的芳氧基二卤代丙烯醚化合物，其中群定义可在说明书中看到。本发明还揭示了将具有通用式(I)的化合物用作农业领域中的杀虫剂，以及使用具有通用式(I)的化合物作为活性成分的杀虫组合物。