2,6-dimethyl-ε-caprolactone | 55879-32-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2,6-dimethyl-ε-caprolactone
• 英文别名: 3,7-dimethyloxepan-2-one；3,7-Dimethyl-oxepan-2-on
• CAS: 55879-32-8
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: RMGLXNNPIUPFQA-UHFFFAOYSA-N

物化性质

• 沸点：
  96-97 °C(Press: 1.5 Torr)
• 密度：
  0.937±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-dimethyl-ε-caprolactone 在 4-二甲氨基吡啶 、 高氯酸 、 palladium 10% on activated carbon 、 氢气 、 三甲基铝 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 54.83h， 生成 cis-2,6-dimethyl-piperidine-1-carboxylic acid methyl ester
  参考文献：
  名称：

  的光化学重排Ñ -Mesyloxylactams：立体专一形成Ñ -Heterocycles

  摘要：

  N-甲氧基内酰胺类对各种环大小的N-杂环进行有效的环收缩。产率随羰基的取代度α而增加。保留了手性迁移碳的立体化学信息，使该反应成为众所周知的霍夫曼，库尔蒂乌斯，洛森和施密特重排的合成有用补充。

  DOI：

  10.1021/jo101805q
• 作为产物：
  描述：

  二甲基环已酮 在 sodium persulfate 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 生成 2,6-dimethyl-ε-caprolactone
  参考文献：
  名称：

  A mild and clean Baeyer–Villiger oxidation of ketones using sodium peroxydisulfate as oxidant catalyzed by silica-supported aluminum chloride

  摘要：

  二硫酸钠被用作拜耶尔-维利格氧化反应的氧化剂，在室温下以硅胶负载的氯化铝（硅胶-AlCl3）为催化剂，对多种环状和非环状酮进行了氧化。该催化剂通过一个简单的制备过程得到，在以环境友好的二硫酸钠作为氧化剂的情况下，表现出对酮的拜耶尔-维利格氧化反应的高催化活性。

  DOI：

  10.1007/s13738-011-0064-1

文献信息

• CYTOTOXIC AGENTS COMPRISING NEW ANSAMITOCIN DERIVATIVES
  申请人：ImmunoGen, Inc.

  公开号：US20160058882A1

  公开（公告）日：2016-03-03

  New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

  披露了带有连接基团的新型安沙米托辛衍生物。还披露了合成这些新型安沙米托辛衍生物的方法以及它们与细胞结合剂的连接方法。安沙米托辛衍生物-细胞结合剂偶联物作为治疗剂非常有用，它们能特异性地传递到目标细胞并具有细胞毒性。与先前描述的药物相比，这些偶联物在动物肿瘤模型中显示出显著提高的治疗效果。
• Cytotoxic agents comprising new ansamitocin derivatives
  申请人：Chari Ravi V. J.

  公开号：US09090629B2

  公开（公告）日：2015-07-28

  New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

  本文披露了一种新的含有连接基团的ansamitocin衍生物。同时，还披露了合成这些新的ansamitocin衍生物以及将它们连接到细胞结合剂的方法。这些ansamitocin衍生物-细胞结合剂共轭物作为治疗剂具有特异性地传递到目标细胞并具有细胞毒性的特点。与以前描述的治疗剂相比，这些共轭物在动物肿瘤模型中表现出极大的治疗效果。
• BIODEGRADABLE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：EP2792372A1

  公开（公告）日：2014-10-22

  Provided is a medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure. Furthermore, the medical adhesive also has the potential to be used as a tissue engineered material.

  本发明提供了一种可进行交联共聚的具有良好生物降解性能的医用粘合剂，该粘合剂由单-α-氰基丙烯酸酯和双-α-氰基丙烯酸二元醇酯单体分子组成。单-α-氰基丙烯酸酯结构中的烯烃键在无限小阴离子存在下聚合形成固体三维高聚物；三维高聚物在网状骨架链上设有降解位点，降解路径清晰，降解产物可吸收。该医用粘合剂可用于伤口粘合、大面积伤口止血以及内脏和软组织伤口闭合。此外，这种医用粘合剂还有可能用作组织工程材料。
• POLYROTAXANE, PRODUCTION METHOD THEREFOR, AND OPTICAL COMPOSITION CONTAINING SAID POLYROTAXANE
  申请人：Tokuyama Corporation

  公开号：EP3345954A1

  公开（公告）日：2018-07-11

  The present invention provides an optical composition from which an optical article having reduced poor appearance such as cloudiness and optical strain during lens base material production can be obtained, and when a photochromic compound is added, a photochromic cured body having excellent photochromism and mechanical strength can also be formed, and a polyrotaxane used therefor. The polyrotaxane has a composite molecular structure formed of an axle molecule and a plurality of cyclic molecules clathrating the axle molecule, satisfying at least one of (X) and (Y). (X): A side chain having a secondary or tertiary hydroxyl group is introduced into at least part of the cyclic molecule of the polyrotaxane. (Y): A side chain having a group represented by -A (A is an organic group, and contains at least one hydroxyl group) is introduced into at least part of the cyclic molecule of the polyrotaxane, and a pKa of the hydroxyl group of the compound represented by H-A is 6 or more and less than 14.

  本发明提供了一种光学组合物，通过该光学组合物可以获得在镜片基底材料生产过程中减少外观不良（如浑浊和光学应变）的光学产品，并且在添加光致变色化合物时，还可以形成具有优异光致变色性和机械强度的光致变色固化体，以及用于该固化体的聚罗他赛烷。该聚罗他赛烷具有复合分子结构，由一个轴分子和多个包覆轴分子的环状分子组成，至少满足（X）和（Y）中的一项。(X):在聚龙齿杉烷环状分子的至少一部分中引入具有仲羟基或叔羟基的侧链。(Y):将具有-A（A 为有机基团，且至少含有一个羟基）代表的基团的侧链引入聚罗他赛的环状分子的至少一部分，且 H-A 代表的化合物的羟基的 pKa 为 6 或以上且小于 14。
• Polystyrene-bound phenylseleninic acid: catalytic oxidations of olefins, ketones, and aromatic systems
  作者：Richard T. Taylor、Lawrence A. Flood

  DOI：10.1021/jo00174a003

  日期：1983.12