(R)-(-)-4-bromo-3-methyl-1-butanol | 128693-48-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-(-)-4-bromo-3-methyl-1-butanol
• 英文别名: (R)-4-bromo-3-methylbutan-1-ol；(3R)-4-bromo-3-methylbutan-1-ol
• CAS: 128693-48-1
• 化学式: C₅H₁₁BrO
• 分子量: 167.046
• InChiKey: XJENZFJXAHFAQI-RXMQYKEDSA-N

物化性质

• 沸点：
  195.2±23.0 °C(Predicted)
• 密度：
  1.367±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  叔丁基二甲硅基三氟甲磺酸酯 、 (R)-(-)-4-bromo-3-methyl-1-butanol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到(R)-(-)-4-bromo-3-methyl-1-O-tert-butyldimethylsilylbutan-1-ol
  参考文献：
  名称：

  New and convenient synthesis of (R)-(+)-4,5-Dihydro-4-methyl-2(3H)-furanone and (R)-(-)-4-Bromo-3-methyl-1-O-tert-butyldimethyl-silylbutan-1-ol

  摘要：

  A convenient partial synthesis of the lactone (+)-10 is reported starting from the readily available methyl (S)-(+)-3-hydroxy-2-methylpropanoate (+)-1. Furthermore, an efficient. three step route to the optically active saturated isoprene unit (-)-13 in high yield starting from the lactone (+)-10 is reported for the first time.

  DOI：

  10.1002/(sici)1521-3897(199901)341:1<65::aid-prac65>3.0.co;2-u
• 作为产物：
  描述：

  (3R)-3-Methyl-4-tert-butyldimethylsilyloxybutanonitrile 在 硫酸 、 氢溴酸 、 二异丁基氢化铝 作用下， 以 正己烷 、 溶剂黄146 为溶剂， 反应 28.0h， 生成 (R)-(-)-4-bromo-3-methyl-1-butanol
  参考文献：
  名称：

  New and convenient synthesis of (R)-(+)-4,5-Dihydro-4-methyl-2(3H)-furanone and (R)-(-)-4-Bromo-3-methyl-1-O-tert-butyldimethyl-silylbutan-1-ol

  摘要：

  A convenient partial synthesis of the lactone (+)-10 is reported starting from the readily available methyl (S)-(+)-3-hydroxy-2-methylpropanoate (+)-1. Furthermore, an efficient. three step route to the optically active saturated isoprene unit (-)-13 in high yield starting from the lactone (+)-10 is reported for the first time.

  DOI：

  10.1002/(sici)1521-3897(199901)341:1<65::aid-prac65>3.0.co;2-u

文献信息

• 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amide
  申请人：Novartis Corporation

  公开号：US05719141A1

  公开（公告）日：1998-02-17

  Compounds of the formula I ##STR1## in which R.sub.1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a carbonyl or methylene group, R.sub.2 and R.sub.3 independently of one another are hydrogen or lower alkyl or, together with the carbon atom with which they are bonded, are a cycloalkylidene radical, R.sub.4 is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl, R.sub.5 is hydroxyl, lower alkanoyloxy or lower alkoxycarbonyloxy, R.sub.6 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl-lower alkyl, aryl-lower alkyl or heteroaryl-lower alkyl having 5 to 7 ring atoms in the heteroaryl ring and R.sub.7 is hydrogen or lower alkyl, or R.sub.6 and R.sub.7, together with the carbon atom with which they are bonded, are a cydoalkylidene radical and R.sub.8 denotes an aliphatic, cycloaliphatic-aliphatic or heteroarylaliphatic radical, and their salts can be used as active ingredients for medicaments for treatment of high blood pressure.

  公式I的化合物##STR1##中，其中R.sub.1是芳基氨基，N-芳基-N-(较低烷氧基-较低烷基)-氨基，N-芳基-N-芳基-较低烷基-氨基或通过环碳原子连接的杂环基，X是羰基或亚甲基基团，R.sub.2和R.sub.3彼此独立地是氢或较低烷基，或者与它们连接的碳原子一起是环烷基亚甲基基团，R.sub.4是氢，较低烷基，较低烷酰基或较低烷氧羰基，R.sub.5是羟基，较低烷酰氧基或较低烷氧羰氧基，R.sub.6是氢，较低烷基，较低烯基，较低炔基，环烷基，环烷基-较低烷基，芳基-较低烷基或杂环芳基-较低烷基，在杂环芳基环中有5到7个环原子，R.sub.7是氢或较低烷基，或者R.sub.6和R.sub.7与它们连接的碳原子一起是环烷基亚甲基基团，R.sub.8表示脂肪，环脂肪-脂肪或杂环脂肪基团，它们的盐可用作治疗高血压药物的活性成分。