4-(2-methoxyethoxy)pyridine | 86450-37-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2-methoxyethoxy)pyridine
• CAS: 86450-37-5
• 化学式: C₈H₁₁NO₂
• mdl: MFCD18802535
• 分子量: 153.181
• InChiKey: UVBGINQLWGPQLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 4-(2-methoxyethoxy)pyridine 在 lithium diisopropyl amide 作用下， 生成 4-(2-methoxyethoxy)-3-trimethylsilylpyridine
  参考文献：
  名称：

  Wada, Akimori; Kanatomo, Shoichi; Nagai, Sotoo, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 3, p. 1016 - 1022

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯吡啶 、 二氧化碳 在 sodium 作用下， 以 乙二醇甲醚 为溶剂， 生成 4-(2-methoxyethoxy)pyridine
  参考文献：
  名称：

  Cephem compounds

  摘要：

  该发明涉及具有高抗微生物活性的头孢类化合物，其化学式为：##STR1## 其中R.sup.1是氨基或受保护的氨基基团；R.sup.2是较低的烷基，可能被取代为一个羧基，较低的烯基，较低的炔基，环(较低)烷基或环(较低)烯基；R.sup.3是较低的烷基氨基，N-(较低)烷酰基(较低)烷基氨基，二(较低)烷基氨基，磺酸(较低)烷基氨基，羟基(较低)烷基氨基，N-(较低)烷酰羟基(较低)烷基氨基，酰氧(较低)烷基，烯酰氧(较低)烷基，较低的烷氧(较低)烷氧(较低)烷基，二(较低)烷基氨基(较低)烷基，较低的烷基硫(较低)烷基，较低的烷基硫，较低的烷氧，较低的烷氧(较低)烷氧，羟基(较低)烷氧，较低的烷磺酰基(较低)烷基，羟基(较低)烷硫，二(较低)烷基氨基(较低)烷硫，四唑基，四唑基硫，四唑基硫(较低)烷基或二氢三嗪基硫(较低)烷基，取代为醛基、羟基和较低烷基；R.sup.4是氢或较低烷基；以及其药学上可接受的盐。

  公开号：

  US04521413A1

文献信息

• SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS
  申请人：PLAYER Mark R.

  公开号：US20110218197A1

  公开（公告）日：2011-09-08

  The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

  本发明涉及替代的氮杂双环咪唑衍生物，含有它们的药物组合物以及它们在治疗由TRP M8调节的疾病和症状中的用途，包括但不限于炎症性疼痛、炎症性过敏症、炎症性过敏性疾病、神经病性疼痛、神经性寒冷痛觉过敏、炎症性体感过敏、炎症性内脏过敏、受寒加重的心血管疾病和受寒加重的肺部疾病。
• Rhodanine Derivatives, a Process for the Preparation Thereof and Pharmaceutical Composition Containing the Same
  申请人：Ryu Seong Eon

  公开号：US20090042872A1

  公开（公告）日：2009-02-12

  Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.

  本文披露了罗丹宁衍生物、其制备方法以及含有相同物质的药物组合物。这些罗丹宁衍生物具有对蛋白磷酸酶（PPase）如PTP1B、Prl-3、LAR、CD45、Cdc25A、Cdc25B、Cdc25C、Yop、PP1和VHR的抑制活性，并可用于预防和治疗PPase引起的疾病，包括自身免疫疾病、糖尿病、糖耐量受损、胰岛素抵抗、肥胖、癌症等，当其抑制活性被调节时。
• Multifunctional self-decontaminating surface coating
  申请人：Wynne H. James

  公开号：US20070122438A1

  公开（公告）日：2007-05-31

  A coating having an adhesive hydrophilic polymer and an amphiphilic additive. The amphiphilic additive has a hydrophilic chain, a biocidal functional group bonded to the hydrophilic chain, and a hydrophobic moiety bonded to the hydrophilic chain or to the biocidal functional group. A method of forming a biocidal surface by providing an article, and coating the article with the above coating. A compound having the formula: Y—(O—Ch 2 —Ch 2 ) n —R—(CH 2 ) m —CH 3 . Y is CH 3 or H. R is X is a halogen, and m and n are independently selected positive integers.

  一种具有粘附性亲水聚合物和两性表面活性剂的涂层。两性表面活性剂具有亲水链，生物杀灭功能基固定在亲水链上，以及疏水基固定在亲水链或生物杀灭功能基上。通过提供物品并使用上述涂层对物品进行涂覆来形成生物杀灭表面的方法。化合物的公式为：Y—（O—Ch2—Ch2）n—R—（CH2）m—CH3。其中，Y为CH3或H。R为X为卤素，m和n是独立选择的正整数。
• MULTIFUNCTIONAL SELF-DECONTAMINATING SURFACE COATING
  申请人：Wynne H. James

  公开号：US20080102281A1

  公开（公告）日：2008-05-01

  A coating having an adhesive hydrophilic polymer and an amphiphilic additive. The amphiphilic additive has a hydrophilic chain, a biocidal functional group bonded to the hydrophilic chain, and a hydrophobic moiety bonded to the hydrophilic chain or to the biocidal functional group. A method of forming a biocidal surface by providing an article, and coating the article with the above coating. A compound having the formula:

  一种具有粘附性亲水聚合物和两性添加剂的涂层。该两性添加剂具有亲水链，生物杀菌功能基团与亲水链结合，以及与亲水链或生物杀菌功能基团结合的疏水基团。通过提供一种物品并使用上述涂层对该物品进行涂覆的方法形成生物杀菌表面。一种具有以下公式的化合物：
• New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and intermediate products for their preparation
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0074653A2

  公开（公告）日：1983-03-23

  New cephem cumpounds of the formula: wherein R' is ammo or a protected amino group. R2 is lower aliphatic hydrocarbon group which may be substituted with suitable substituent(s), cylclopower)lalkyl or cyclo(lower)alkenyl; R3 defines certain subsituents, R4 is hydrogen or lower alkyl, and pharmaceutically acceptable salts thereof, processes for their preparation, and a pharmaceutrcal antibacterial composition comprising the above compound in associationwith a pharmaceutically acceptable substantially carrier or excipient.The Invention refers also to compounds of the formula

  式中的新头孢化合物： 式中 R' 是氨基或受保护的氨基。 R2 是可被适当取代基取代的低级脂肪烃基、环烷基或环（低级）烯基； R3 定义某些亚基、 R4 是氢或低级烷基，及其药学上可接受的盐、制备工艺，以及由上述化合物与药学上可接受的基本载体或赋形剂组成的药用抗菌组合物。