5,5,8,8-tetramethyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-one | 102296-82-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5,5,8,8-tetramethyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-one
• 英文别名: 2,3,5,6,7,8-hexahydro-5,5,8,8-tetramethylcyclopenta[b]naphthalen-1-one；5,5,8,8-tetramethyl-1,2,6,7-tetrahydrocyclopenta[b]naphthalen-3-one
• CAS: 102296-82-2
• 化学式: C₁₇H₂₂O
• 分子量: 242.361
• InChiKey: HHYYDVAFVOGXBT-UHFFFAOYSA-N

物化性质

• 沸点：
  351.4±42.0 °C(Predicted)
• 密度：
  1.015±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  5,5,8,8-tetramethyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-one 在 sodium tetrahydroborate 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 反应 4.75h， 生成 5,5,8,8-四甲基-5,6,7,8-四氢-1H-环戊二烯并[B]萘
  参考文献：
  名称：

  POLYMERIZATION CATALYSTS

  摘要：

  本公开的实施例针对具有改善乙烯串联和/或改善催化剂生产率的聚合催化剂。例如，本公开提供了一种化学式（I）的聚合催化剂，其中R1至R12中的每一个独立地是C1到C20烷基、芳基或芳基烷基，或氢，其中至少有一个R4到R7不是氢，其中M是第4族金属，且每个X独立地是卤素、C1到C20烷基、芳基烷基或氢。

  公开号：

  US20190263944A1
• 作为产物：
  描述：

  5,5,8,8-四甲基-5,6,7,8-四氢-2-萘甲醛 在 palladium on activated charcoal sodium hydroxide 、 正丁基锂 、 三氯化铝 、 氯化亚砜 、 氢气 、 N,N-二甲基甲酰胺 作用下， 以 乙醇 为溶剂， 反应 9.0h， 生成 5,5,8,8-tetramethyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-one
  参考文献：
  名称：

  Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids

  摘要：

  Alkyl-substituted azobenzene-4-carboxylic acids are potent differentiation inducers of human promyelocytic leukemia cell line HL-60 to mature granulocytes. Their structure-activity relationships are very similar to those of other retinoidal benzoic acids which are generally represented by 4 and named retinobenzoic acids. The structure-activity relationships of azobenzenecarboxylic acids can also be applied to the known retinoid TTNPB (3). Thus, (E)-4-[2-(3,4-diisopropylphenyl)-1-propenyl]benzoic acid (St30 (28] and (E)-4-[2-(3-tert-butylphenyl)ethenyl]benzoic acid (St40 (29], the acyclic alkyl analogues of TTNPB, are nearly as active as retinoic acid. Among the oxidatively derived compounds (Az90, Ep series and Ox series) of azobenzene- or stilbenecarboxylic acids, Az90 (71) and Ep80 (61) have strong activities. However, all the bishydroxylated derivatives of TTNPB are inactive, while a diketo analogue Ox580 (69) has only weak potency. The activities of conformationally restricted compounds of TTNPB offer some information on the stereochemistry of the active form of these retinoidal compounds.

  DOI：

  10.1021/jm00125a027

文献信息

• 전이금속 화합물 및 이를 포함하는 촉매 조성물
  申请人：LG CHEM, LTD. 주식회사 엘지화학(120010134563) Corp. No ▼ 110111-2207995BRN ▼107-81-98139

  公开号：KR20210037461A

  公开（公告）日：2021-04-06

  본 발명은 신규한 리간드 화합물, 전이금속 화합물 및 이를 포함하는 촉매 조성물에 관한 것이다. 본 발명의 신규한 전이금속 화합물은 고온에서 높은 촉매 활성을 나타내며, 올레핀계 중합체의 제조에 있어 중합 반응 촉매로 유용하게 사용될 수 있어, 이를 이용하여 저밀도이면서 초저분자량인 중합체를 얻을 수 있다.

  本发明涉及一种新型的螯合物、过渡金属化合物和包含它们的催化剂组合物。本发明的新型过渡金属化合物在高温下表现出高催化活性，并可用作烯烃类聚合物的制备中的催化剂，从而可以通过其获得低密度且超低分子量的聚合物。
• Tricyclic retinoids, methods for their production and use
  申请人：Ligand Pharmaceuticals, Inc.

  公开号：US05770382A1

  公开（公告）日：1998-06-23

  Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.

  提供具有活性的三环类维甲酸受体和/或维甲酸X受体的类维甲酸类化合物。还提供了包含这些三环类维甲酸类化合物的药物组合物以及它们的治疗用途的方法。
• Synthesis of geometrically defined exocyclic olefins
  作者：Youssef L. Bennani、C.-K. Hwang、Stacie S. Canan Koch、Kristin S. Marron、Laura J. Dar-ti、Beth-Ann Badea、Alex M. Nadzan

  DOI：10.1016/0040-4039(96)01885-0

  日期：1996.11

  bicyclic and tricyclic ketones with lithium ethynyl acetylide, followed by the addition of a catalytic amount of CSA or p-TSA, affords the corresponding exocyclic olefinic ester in good yields, and geometric ratios up to 13:1 favoring the cis olefin. This procedure represents an addition to the repertoire of olefination methods and can readily be extended to other cyclic and acyclic systems.

  用乙炔基乙炔化锂处理双环和三环酮，然后加入催化量的CSA或p-TSA，可得到高产率的相应环外烯烃酯，且几何比高达13：1，有利于顺式烯烃。该方法是对烯烃化方法的补充，可以很容易地扩展到其他环状和非环状体系。
• Integrated process for preparation of diene complexes
  申请人：The Dow Chemical Company

  公开号：US06127563A1

  公开（公告）日：2000-10-03

  Disclosed is a process for preparing bridged Group 4 metal complexes containing a neutral diene ligand starting from the corresponding novel, metal diene containing complexes by reaction thereof with the divalent derivative of a bridged bidentate ligand compound. The novel, intermediate metal diene complexes, their formation from tetravalent metal salts and an integrated process combining both process steps are claimed.

  本发明公开了一种制备含有中性二烯配体的桥联第四族金属配合物的方法，该方法从相应的新型金属二烯配合物出发，通过与桥联双齿配体化合物的二价衍生物反应而得到。本发明还声明了所述新型中间体金属二烯配合物、其从四价金属盐中形成的方法以及将两个过程步骤组合在一起的综合过程。
• Polymerization catalysts
  申请人：Univation Technologies, LLC

  公开号：US10982024B2

  公开（公告）日：2021-04-20

  Embodiments of the present disclosure directed towards polymerization catalysts having improved ethylene enchainment and/or improved catalyst productivity. As an example, the present disclosure provides a polymerization catalyst of Formula (I), wherein each of R1 to R12 is independently a C1 to C20 alkyl, aryl or aralkyl group, or a hydrogen, wherein at least one of R4 to R7 is not a hydrogen, wherein M is a Group 4 metal, and wherein, each X is independently a halide, C1 to C20 alkyl, aralkyl or hydrogen.

  本公开的实施方案针对具有改进的乙烯链化和/或改进的催化剂生产率的聚合催化剂。作为一个例子，本公开提供了一种式（I）的聚合催化剂，其中 R1 至 R12 中的每一个都独立地为 C1 至 C20 烷基、芳基或芳烷基或氢，其中 R4 至 R7 中的至少一个不是氢，其中 M 为第 4 族金属，并且其中每一个 X 都独立地为卤化物、C1 至 C20 烷基、芳烷基或氢。