2-(5-巯基-1,3,4-噻二唑-2-硫代)琥珀酸 | 125605-97-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2-(5-巯基-1,3,4-噻二唑-2-硫代)琥珀酸
• 中文别名: 2-(5-巯基-1,3,4-噻二唑-2-硫基)琥珀酸；2-(5-巯基 -1,3,4-噻二唑-2-硫代)琥珀酸
• 英文名称: 2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]butanedioic acid
• 英文别名: 2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)sulfanyl]butanedioic acid
• CAS: 125605-97-2
• 化学式: C₆H₆N₂O₄S₃
• 分子量: 266.323
• InChiKey: YUMSRJNRCPVTBZ-UHFFFAOYSA-N

物化性质

• 沸点：
  421.9±55.0 °C(Predicted)
• 密度：
  1.94±0.1 g/cm3(Predicted)
• 溶解度：
  >39.9 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  182
• 氢给体数：
  3
• 氢受体数：
  8

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  iron (III) chloride hexahydrate 、 2-(5-巯基-1,3,4-噻二唑-2-硫代)琥珀酸 在 三乙胺 作用下， 以 水 为溶剂， 以94.2%的产率得到
  参考文献：
  名称：

  Venter, Monica M.; Goga, Firuţa; Bercean, Vasile N., Revue Roumaine de Chimie, 2014, vol. 59, # 11-12, p. 989 - 996

  摘要：

  DOI：

文献信息

• [EN] METHODS AND USE OF BIFUNCTIONAL ENZYME-BUILDING CLAMP-SHAPED MOLECULES<br/>[FR] PROCÉDÉS ET UTILISATION DE MOLÉCULES EN FORME DE PINCE GÉNÉRANT UNE ENZYME BIFONCTIONNELLE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2012125913A1

  公开（公告）日：2012-09-20

  This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for inhibiting cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, and methods for treating these disorders.

  这项发明涉及癌症治疗领域。更具体地，它涉及一些化合物，这些化合物是用于抑制细胞增殖异常的有效药物，特别是那些由EGFR过度活跃和/或不适当活跃引起的疾病，包括EGFR相关的癌症，并提供了治疗这些疾病的方法。
• RESIST POLYMER, RESIST COMPOSITION, PROCESS FOR PATTERN FORMATION, AND STARTING COMPOUNDS FOR PRODUCTION OF THE RESIST POLYMER
  申请人：Momose Hikaru

  公开号：US20090198065A1

  公开（公告）日：2009-08-06

  To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like. In formulas (1) and (2), n represents an integer of 2 to 24; J represents a single bond or a divalent hydrocarbon group which may have a substituent/heteroatom when n=2, or represents an n-valent hydrocarbon group which may have a substituent/heteroatom when n≧3; E represents a residue of a polymerization terminator, a chain transfer agent or a polymerization initiator; K 1 and K 2 each represent at least one selected from alkylene, cycloalkylene, oxyalkylene, arylene, a divalent thiazoline ring, a divalent oxazoline ring and a divalent imidazoline ring; L 1 and L 2 each represent at least one selected from —C(O)O—, —C(O)— and —OC(O)—; M 1 , M 2 and M 3 each represent at least one selected from alkylene, cycloalkylene, oxyalkylene and arylene; Y, Y 1 and Y 2 each represent an acid-decomposable linkage; k1, k2, l1, l2, m1, m2, and m3 each represent 0 or 1; and R 1 represents H or a methyl group.

  提供一种抗蚀聚合物，其由一个具有结构式（1）或（2）所表示的酸分解单元作为结构单元，能够在DUV准分子激光微影或类似工艺中表现出小的线边粗糙度并产生少量缺陷。在式（1）和（2）中，n表示2至24的整数；J表示单键或二价碳氢基团，当n=2时可以具有取代基/杂原子，或者当n≥3时可以表示n价碳氢基团，可以具有取代基/杂原子；E表示聚合终止剂、链转移剂或聚合引发剂的残基；K1和K2分别表示至少选择自烷基、环烷基、氧烷基、芳烃、二价噻唑环、二价噁唑环和二价咪唑环中的至少一种；L1和L2分别表示至少选择自—C（O）O—、—C（O）—和—OC（O）—中的至少一种；M1、M2和M3分别表示至少选择自烷基、环烷基、氧烷基和芳烃中的至少一种；Y、Y1和Y2分别表示酸分解键；k1、k2、l1、l2、m1、m2和m3分别表示0或1；R1表示H或甲基基团。
• RESIN COMPOSITION AND SEMICONDUCTOR DEVICE BOARD
  申请人：Osaku Yumi

  公开号：US20140087136A1

  公开（公告）日：2014-03-27

  A resin composition which contains a binder resin (A), radiation-sensitive compound (B), silane-modified resin (C), and antioxidant (D), wherein a content of the silane-modified resin (C) is 0.1 to 150 parts by weight with respect to 100 parts by weight of the binder resin (A), a content of the antioxidant (D) is 0.1 to 10 parts by weight with respect to 100 parts by weight of the binder resin (A), and an amount of warping is 14 μm or less when using the resin composition to form a thickness 2 to 3 μm resin film and baking the formed resin film at 230° C. is provided.

  一种树脂组合物，包含粘合剂树脂（A），辐射敏感化合物（B），硅改性树脂（C）和抗氧化剂（D），其中硅改性树脂（C）的含量相对于100份粘合剂树脂（A）为0.1至150份重量，抗氧化剂（D）的含量相对于100份粘合剂树脂（A）为0.1至10份重量，并且使用该树脂组合物形成2至3μm厚度的树脂膜并在230°C下烘烤形成的树脂膜翘曲量为14μm或以下。
• INORGANIC-ORGANIC HYBRID MATERIAL, OPTICAL MATERIAL USING SAME, AND INORGANIC-ORGANIC COMPOSITE COMPOSITION
  申请人：Nippon Kasei Chemical Company Limited

  公开号：EP2586826A1

  公开（公告）日：2013-05-01

  The disclosed inorganic-organic hybrid material can realize an optical material that combines the conflicting properties of flexibility and high index of refraction, has a low degree of yellowness, and is highly transparent. Said inorganic-organic hybrid material contains both an inorganic component and an organic component, with the inorganic component constituting between 20% and 80% of the mass of the inorganic-organic hybrid material, and has an index of refraction of at least 1.60. When said inorganic-organic hybrid material is used to fabricate a strip specimen 1,000 µm thick, 5 mm wide, and 70 mm long, said specimen does not crack when wrapped 180° around a cylindrical metal rod with a diameter of 10 mm at 25°C. Also disclosed is an inorganic-organic composite composition that contains: a radiation-curable monomer; inorganic particles that have crystallite diameters between 1 and 10 nm as calculated from the half-height width of a crystalline peak as per X-ray diffraction; and a sulfur-containing organic compound. The curable monomer includes a monofunctional radiation-curable monomer and a polyfunctional radiation-curable monomer. In terms of sulfur-atom content, the sulfur-containing organic compound constitutes between 1.5% and 10% of the inorganic-organic composite composition by mass.

  所公开的无机-有机杂化材料可以实现一种兼具柔韧性和高折射率这两种相互矛盾的特性、低黄度和高透明性的光学材料。所述无机-有机杂化材料包含无机成分和有机成分，其中无机成分占无机-有机杂化材料质量的 20% 至 80%，折射率至少为 1.60。当上述无机-有机杂化材料用于制造厚度为 1,000 微米、宽度为 5 毫米、长度为 70 毫米的带状试样时，在 25°C 温度下，当试样 180° 缠绕在直径为 10 毫米的圆柱形金属棒上时，不会出现裂纹。还公开了一种无机-有机复合材料组合物，其中包含：辐射固化单体；无机颗粒，根据 X 射线衍射结晶峰的半高宽度计算，无机颗粒的结晶直径在 1 到 10 纳米之间；以及含硫有机化合物。固化单体包括单官能团辐射固化单体和多官能团辐射固化单体。就硫原子含量而言，含硫有机化合物占无机-有机复合材料组合物质量的 1.5% 至 10%。
• RESIN COMPOSITION, RESIN FILM, AND ELECTRONIC COMPONENT
  申请人：Zeon Corporation

  公开号：EP3434731A1

  公开（公告）日：2019-01-30

  A resin composition comprising a cyclic olefin polymer (A) having a protonic polar group, a cross-linking agent (B), and an organic solvent (C), wherein the organic solvent (C) contains diethylene glycol ethyl methyl ether, and a content of diethylene glycol dimethyl ether contained in the organic solvent (C) is 10 ppm by weight or less when a content of the diethylene glycol ethyl methyl ether is 100 wt%, is provided.

  本发明提供了一种树脂组合物，该树脂组合物由具有质子极性基团的环烯烃聚合物（A）、交联剂（B）和有机溶剂（C）组成，其中有机溶剂（C）含有二乙二醇乙基甲基醚，当二乙二醇乙基甲基醚的含量为 100 wt%时，有机溶剂（C）中所含的二乙二醇二甲醚的含量为 10 ppm 或以下（按重量计）。