2-((1-ethynylcyclohexyl)oxy)-6-fluoropyridine | 1594110-03-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-((1-ethynylcyclohexyl)oxy)-6-fluoropyridine
• 英文别名: 2-(1-Ethynylcyclohexyl)oxy-6-fluoropyridine；2-(1-ethynylcyclohexyl)oxy-6-fluoropyridine
• CAS: 1594110-03-8
• 化学式: C₁₃H₁₄FNO
• 分子量: 219.259
• InChiKey: SAOMSAOCZSOCFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-((1-ethynylcyclohexyl)oxy)-6-fluoropyridine 在 copper(l) iodide 、 三苯基膦双(三氟甲磺酰亚胺)金 、 bis(tri-phenylphosphine)palladium(II) dichloride 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 4.0h， 生成 1-(2-cyclohexylidene-1-(4-methoxyphenyl)vinyl)-6-fluoropyridin-2(1H)-one
  参考文献：
  名称：

  Divergent Product Selectivity in Gold- versus Silver-Catalyzed Reaction of 2-Propynyloxy-6-fluoropyridines with Arylamines

  摘要：

  A study of the reaction of easily accessible 2-propynyloxy-6-fluoropyridines with arylamines under gold or silver catalysis is described. It has been shown that two types of isomeric oxazolopyridine imine derivatives, which represent unusual heterocyclic motifs, can be selectively obtained in moderate to excellent yields depending on the nature of the metal employed.

  DOI：

  10.1021/ol500939v
• 作为产物：
  描述：

  2,6-二氟吡啶 、 炔环己醇 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 以60%的产率得到2-((1-ethynylcyclohexyl)oxy)-6-fluoropyridine
  参考文献：
  名称：

  Divergent Product Selectivity in Gold- versus Silver-Catalyzed Reaction of 2-Propynyloxy-6-fluoropyridines with Arylamines

  摘要：

  A study of the reaction of easily accessible 2-propynyloxy-6-fluoropyridines with arylamines under gold or silver catalysis is described. It has been shown that two types of isomeric oxazolopyridine imine derivatives, which represent unusual heterocyclic motifs, can be selectively obtained in moderate to excellent yields depending on the nature of the metal employed.

  DOI：

  10.1021/ol500939v

文献信息

• Divergent Product Selectivity in Gold- versus Silver-Catalyzed Reaction of 2-Propynyloxy-6-fluoropyridines with Arylamines
  作者：Colombe Gronnier、Pierre Faudot dit Bel、Guilhem Henrion、Søren Kramer、Fabien Gagosz

  DOI：10.1021/ol500939v

  日期：2014.4.18

  A study of the reaction of easily accessible 2-propynyloxy-6-fluoropyridines with arylamines under gold or silver catalysis is described. It has been shown that two types of isomeric oxazolopyridine imine derivatives, which represent unusual heterocyclic motifs, can be selectively obtained in moderate to excellent yields depending on the nature of the metal employed.