2-fluoro-6-((6-vinylbicyclo[3.2.0]heptan-6-yl)oxy)pyridine | 1345831-16-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-fluoro-6-((6-vinylbicyclo[3.2.0]heptan-6-yl)oxy)pyridine
• 英文别名: 2-[(6-Ethenyl-6-bicyclo[3.2.0]heptanyl)oxy]-6-fluoropyridine；2-[(6-ethenyl-6-bicyclo[3.2.0]heptanyl)oxy]-6-fluoropyridine
• CAS: 1345831-16-4
• 化学式: C₁₄H₁₆FNO
• 分子量: 233.286
• InChiKey: YNNFUDYFZJRVTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  bicyclo[3.2.0]heptan-6-one 在 sodium hydride 作用下， 以 四氢呋喃 、 二甲基亚砜 、 mineral oil 为溶剂， 反应 0.5h， 生成 2-fluoro-6-((6-vinylbicyclo[3.2.0]heptan-6-yl)oxy)pyridine
  参考文献：
  名称：

  Elimination versus Ring Opening: A Convergent Route to Alkylidene-Cyclobutanes

  摘要：

  Functionalized alkylidene-cyclobutanes have been prepared from 2-fluoropyridinyl-6-oxy precursors derived from vinyl cyclobutanols by a radical addition elimination process. A wide range of functional groups is tolerated, and the alkylidene-cyclobutanes can be further elaborated Into cyclopentanones. The limitation of this approach resides in the competition with opening of the cyclobutane ring.

  DOI：

  10.1021/ol202798r

文献信息

• Elimination versus Ring Opening: A Convergent Route to Alkylidene-Cyclobutanes
  作者：Julien Brioche、Michal Michalak、Béatrice Quiclet-Sire、Samir Z. Zard

  DOI：10.1021/ol202798r

  日期：2011.12.2

  Functionalized alkylidene-cyclobutanes have been prepared from 2-fluoropyridinyl-6-oxy precursors derived from vinyl cyclobutanols by a radical addition elimination process. A wide range of functional groups is tolerated, and the alkylidene-cyclobutanes can be further elaborated Into cyclopentanones. The limitation of this approach resides in the competition with opening of the cyclobutane ring.