2-(5-环丙基-四唑-2-基)-乙胺 | 1056623-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(5-环丙基-四唑-2-基)-乙胺
• 英文名称: 2-(5-cyclopropyl-tetrazol-2-yl)-ethylamine
• 英文别名: 2-(5-cyclopropyltetrazol-2-yl)ethanamine
• CAS: 1056623-36-9
• 化学式: C₆H₁₁N₅
• 分子量: 153.187
• InChiKey: RMUABEPMDOCNLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(5-环丙基-四唑-2-基)-乙胺 、 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 1-[6-[5-(Tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-[2-(5-cyclopropyltetrazol-2-yl)ethyl]urea
  参考文献：
  名称：

  Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation

  摘要：

  Dual PI3K gamma/delta inhibitors have recently been shown to be suitable targets for inflammatory and respiratory diseases. In a recent study we described the discovery of selective PI3K gamma inhibitors based on a triazolopyridine scaffold. Herein, we describe the elaboration of this structural class into dual PI3K gamma/delta inhibitors with excellent selectivity over the other PI3K isoforms and the general kinome. Structural optimization led to the identification of two derivatives which showed significant efficacy in an acute model of lung inflammation. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.05.121
• 作为产物：
  描述：

  5-甲基四氮唑 、 5-环丙基-2H-1,2,3,4-四唑 生成 2-(5-环丙基-四唑-2-基)-乙胺
  参考文献：
  名称：

  5-Phenyl-4-Methyl-Thiazol-2-Yl-Amine Derivatives as Inhibitors of Phosphatidylin Ositol 3 Kinase Enzymes (PI13) For Treatment of Inflammatory Diseases

  摘要：

  在自由或盐形式中，其中Ra，Rb，R2，R3，R4和R5具有规范中指示的含义，对于治疗由磷脂酰肌醇3-激酶介导的疾病是有用的。还描述了含有该化合物的药物组合物以及制备该化合物的过程。

  公开号：

  US20080280871A1

文献信息

• [EN] FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS<br/>[FR] COMPOSÉS BICYCLIQUES FUSIONNÉS ET UTILISATIONS DE CEUX-CI COMME INHIBITEURS DE P13K
  申请人：MERCK SERONO SA

  公开号：WO2009133127A1

  公开（公告）日：2009-11-05

  The invention relates to compounds of formula (I), for the regulation of phosphoinositides 3-kinases activity and related diseases.

  这项发明涉及到式(I)的化合物，用于调节磷脂酰肌醇3-激酶的活性和相关疾病。
• [EN] FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE<br/>[FR] COMPOSÉS BICYCLIQUES FUSIONNÉS UTILISÉS COMME INHIBITEURS DE LA PI3 KINASE
  申请人：MERCK SERONO SA

  公开号：WO2010100144A1

  公开（公告）日：2010-09-10

  The invention relates to compounds of formula (I) for the regulation of phosphoinositides 3-kinases activity and related diseases.

  该发明涉及用于调节磷脂酰肌醇3-激酶活性及相关疾病的化合物（I）的公式。
• [EN] BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROARYLIQUES BICYCLIQUES ET LEUR UTILISATION COMME INHIBITEURS DE KINASE
  申请人：NOVARTIS AG

  公开号：WO2009010530A1

  公开（公告）日：2009-01-22

  Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

  磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药用盐及其前药；新化合物的组合物，可以单独使用或与至少一种额外治疗剂联合使用，携带药用载体；新化合物的用途，可以单独使用或与至少一种额外治疗剂联合使用，用于预防或治疗由生长因子、蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性所特征化的增殖性疾病。
• 5-Phenyl-4-Methyl-Thiazol-2-Yl-Amine Derivatives as Inhibitors of Phosphatidylin Ositol 3 Kinase Enzymes (PI13) For Treatment of Inflammatory Diseases
  申请人：Bloomfield Graham Charles

  公开号：US20080280871A1

  公开（公告）日：2008-11-13

  in free or salt form, wherein R a , R b , R 2 , R 3 , R 4 and R 5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

  在自由或盐形式中，其中Ra，Rb，R2，R3，R4和R5具有规范中指示的含义，对于治疗由磷脂酰肌醇3-激酶介导的疾病是有用的。还描述了含有该化合物的药物组合物以及制备该化合物的过程。
• PI3 KINASE INHIBITORS AND METHODS OF THEIR USE
  申请人：Ni Zhi-Jie

  公开号：US20100075965A1

  公开（公告）日：2010-03-25

  Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.

  磷脂酰肌醇（PI）3激酶抑制剂化合物及其药学上可接受的盐和前药；新化合物的组合物，可以单独使用或与至少一种其他治疗药物结合，与药学上可接受的载体；以及新化合物的用途，可以单独使用或与至少一种其他治疗药物结合，用于预防或治疗增殖性疾病，其特征是生长因子、蛋白质丝氨酸/苏氨酸激酶、磷脂酰肌醇激酶、G蛋白偶联受体和磷酸酶的异常活性。