2-(5-环丙基吡啶-2-基)乙酸 | 121131-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(5-环丙基吡啶-2-基)乙酸
• 英文名称: (5-cyclopropylpyridin-2-yl)acetic acid
• 英文别名: 2-(5-cyclopropylpyridin-2-yl)acetic acid；2-(5-Cyclopropylpyridin-2-yl)acetic acid
• CAS: 121131-75-7
• 化学式: C₁₀H₁₁NO₂
• 分子量: 177.203
• InChiKey: VOUJQDKBSFYLTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane 、 2-(5-环丙基吡啶-2-基)乙酸 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 以10%的产率得到7-[(5-cyclopropylpyridin-2-yl)acetyl]-2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane
  参考文献：
  名称：

  Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

  摘要：

  Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor (GHS-R1a) inverse agonists. Efforts to improve pharmacokinetic and safety profile was achieved by modulating physicochemical properties and, more specifically, emphasizing increased polarity of our chemical series. ortho-Carboxamide containing compounds provided optimal physicochemical, pharmacologic, and safety profile. pH-dependent chemical stability was also assessed with our series.

  DOI：

  10.1021/ml500414n
• 作为产物：
  描述：

  2-溴-5-环丙基吡啶 在 盐酸 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 37.08h， 生成 2-(5-环丙基吡啶-2-基)乙酸
  参考文献：
  名称：

  Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

  摘要：

  Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor (GHS-R1a) inverse agonists. Efforts to improve pharmacokinetic and safety profile was achieved by modulating physicochemical properties and, more specifically, emphasizing increased polarity of our chemical series. ortho-Carboxamide containing compounds provided optimal physicochemical, pharmacologic, and safety profile. pH-dependent chemical stability was also assessed with our series.

  DOI：

  10.1021/ml500414n

文献信息

• [EN] T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF<br/>[FR] ANTAGONISTES DE CANAL CALCIQUE DE TYPE T, ET UTILISATIONS DE CEUX-CI
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2022216386A3

  公开（公告）日：2023-01-12
• IMIDAZO-PYRAZINE DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
  申请人：Merck Sparp & Dohme Corp.

  公开号：US20170107236A1

  公开（公告）日：2017-04-20

  A compound of Formula II or a pharmaceutically acceptable salt thereof, are capable of monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula II, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula II or a pharmaceutically acceptable salt thereof.
• US9796733B2
  申请人：——

  公开号：US9796733B2

  公开（公告）日：2017-10-24
• Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists
  作者：Suvi T. M. Orr、Ramsay Beveridge、Samit K. Bhattacharya、Kimberly O. Cameron、Steven Coffey、Dilinie Fernando、David Hepworth、Margaret V. Jackson、Vishal Khot、Rachel Kosa、Kimberly Lapham、Paula M. Loria、Kim F. McClure、Jigna Patel、Colin Rose、James Saenz、Ingrid A. Stock、Gregory Storer、Maria von Volkenburg、Derek Vrieze、Guoqiang Wang、Jun Xiao、Yingxin Zhang

  DOI：10.1021/ml500414n

  日期：2015.2.12

  Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor (GHS-R1a) inverse agonists. Efforts to improve pharmacokinetic and safety profile was achieved by modulating physicochemical properties and, more specifically, emphasizing increased polarity of our chemical series. ortho-Carboxamide containing compounds provided optimal physicochemical, pharmacologic, and safety profile. pH-dependent chemical stability was also assessed with our series.