5-diethylamino-2-methylpentan-2-ol | 124009-06-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-diethylamino-2-methylpentan-2-ol
• 英文别名: 5-(Diethylamino)-2-methylpentan-2-ol
• CAS: 124009-06-9
• 化学式: C₁₀H₂₃NO
• 分子量: 173.299
• InChiKey: AUVHIVIQQPTOTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-diethylamino-2-methylpentan-2-ol 在 硫酸 、 溶剂黄146 、 乙腈 、 盐酸 、 sodium hydroxide 、 sodium carbonate 作用下， 以 水 为溶剂， 反应 40.0h， 生成 N¹,N¹-diethyl-4-methylpentane-1,4-diamine
  参考文献：
  名称：

  [EN] PYRIDIN-4-YLAMINE COMPOUNDS USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN
  [FR] COMPOSES DE PYRIDIN-4-YLAMINE CONVENANT POUR LE TRAITEMENT DE LA DOULEUR NEUROPATHIQUE

  摘要：

  本发明涉及一种在治疗神经病性疼痛中使用三唑吡啶化合物的方法。本发明还涉及在治疗精神和情绪障碍，如精神分裂症、焦虑、抑郁、躁郁症和恐慌，以及在治疗疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍（如倒班引起的睡眠障碍和时差反应）、药物成瘾、药物滥用、药物戒断和其他疾病中使用三唑吡啶化合物的方法。本发明还涉及选择性结合到Ca通道α2δ-1亚基的新型三唑吡啶化合物。

  公开号：

  WO2005051915A1
• 作为产物：
  描述：

  methyl 4-(diethylamino)-4-oxobutanoate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 11.0h， 生成 5-diethylamino-2-methylpentan-2-ol
  参考文献：
  名称：

  De; Seth; Chandra, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1989, vol. 28, # 2, p. 146 - 149

  摘要：

  DOI：

文献信息

• METAL ALKOXIDE COMPOUND, THIN-FILM-FORMING MATERIAL, METHOD FOR PRODUCING THIN FILM, AND ALCOHOL COMPOUND
  申请人：ADEKA CORPORATION

  公开号：US20150175642A1

  公开（公告）日：2015-06-25

  Disclosed is a metal alkoxide compound having physical properties suitable for a material for forming thin films by CVD, and particularly, a metal alkoxide compound having physical properties suitable for a material for forming metallic-copper thin films. A metal alkoxide compound is represented by general formula (I). A thin-film-forming material including the metal alkoxide compound is described as well. (In the formula, R 1 represents a methyl group or an ethyl group, R 2 represents a hydrogen atom or a methyl group, R 3 represents a C 1-3 linear or branched alkyl group, M represents a metal atom or a silicon atom, and n represents the valence of the metal atom or silicon atom.

  揭示了一种具有适合用于CVD形成薄膜材料的物理性质的金属烷氧化物化合物，特别是一种具有适合用于形成金属铜薄膜材料的金属烷氧化物化合物。金属烷氧化物化合物由通式（I）表示。还描述了包括金属烷氧化物化合物的薄膜形成材料。（在公式中，R1代表甲基基团或乙基基团，R2代表氢原子或甲基基团，R3代表C1-3直链或支链烷基基团，M代表金属原子或硅原子，n代表金属原子或硅原子的价。
• THIN-FILM FORMING RAW MATERIAL FOR USE IN ATOMIC LAYER DEPOSITION METHOD, THIN-FILM FORMING RAW MATERIAL, METHOD FOR PRODUCING THIN-FILM, AND COMPOUND
  申请人：ADEKA CORPORATION

  公开号：US20210340162A1

  公开（公告）日：2021-11-04

  The present invention provides a thin-film forming raw material, which is used in an atomic layer deposition method, including a compound represented by the following general formula (1): where R 1 to R 4 each independently represent an alkyl group having 1 to 5 carbon atoms, and A 1 represents an alkanediyl group having 1 to 5 carbon atoms.

  本发明提供了一种薄膜形成原料，用于原子层沉积方法，包括由以下一般式（1）表示的化合物：其中R1至R4分别独立表示具有1至5个碳原子的烷基基团，A1表示具有1至5个碳原子的烷二基基团。
• RAW MATERIAL FOR FORMING THIN FILM BY ATOMIC LAYER DEPOSITION METHOD AND METHOD FOR PRODUCING THIN FILM
  申请人：ADEKA CORPORATION

  公开号：US20210155638A1

  公开（公告）日：2021-05-27

  Provided is a thin-film forming raw material, which is used in an atomic layer deposition method, including a magnesium compound represented by the following general formula (1): where R 1 represents an isopropyl group, a sec-butyl group, or a tert-butyl group. A thin-film containing a magnesium atom is produced on a surface of a substrate with high productivity through use of the raw material.

  提供了一种用于原子层沉积方法的薄膜形成原料，包括由以下一般式（1）表示的镁化合物： 其中，R1代表异丙基基团、仲丁基团或叔丁基团。通过使用该原料，在基板表面上高效地生产含有镁原子的薄膜。
• Pyridin-4-ylamine compounds useful in the treatment of neuropathic pain
  申请人：Lim Jongwon

  公开号：US20070099950A1

  公开（公告）日：2007-05-03

  The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders—such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α 2 δ-1 subunit of Ca channels.

  本发明涉及使用三唑-吡啶嗪化合物治疗神经病性疼痛的方法。本发明还涉及使用三唑-吡啶嗪化合物治疗精神和情绪障碍，例如精神分裂症、焦虑、抑郁、双相情感障碍和惊恐症，以及治疗疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍，如倒班工作引起的睡眠障碍和时差反应，药物成瘾、药物滥用、戒断症状和其他疾病。本发明还涉及新型的三唑-吡啶嗪化合物，它们选择性地结合到钙通道的α2δ-1亚单位上。
• New Spin Probes: Tri- and Hexacationic Derivatives of Stable Tetrathiatriarylmethyl Radicals
  作者：D. V. Trukhin、O. Yu. Rogozhnikova、T. I. Troitskaya、A. A. Kuzhelev、E. V. Amosov、H. J. Halpern、V. V. Koval’、V. M. Tormyshev

  DOI：10.1134/s1070428019030035

  日期：2019.3

  The reaction of Finland trityl with tertiary aliphatic alcohols containing a terminal tertiary amino group, followed by quaternization of the amino groups, afforded new highly polar tri- and hexacationic derivatives. The obtained compounds are characterized by a sharp singlet signal in the EPR spectrum and are soluble in water over a wide pH range.

  芬兰三苯甲基与含有末端叔氨基的脂肪族叔醇反应，然后对氨基进行季铵化，得到了新的高极性三阳离子和六阳离子衍生物。所获得的化合物的特征在于EPR光谱中的尖峰单峰信号，并且在宽pH范围内可溶于水。