3,3,5c-trimethyl-cyclohexan-r-ol | 147332-78-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3,5c-trimethyl-cyclohexan-r-ol
• 英文别名: trans-3,3,5-trimethylcyclohexanol；trans-3.3.5-Trimethyl-cyclohexanol-(1)；trans-3,3,5-Trimethyl-cyclohexanol；trans-3,5,5-Trimethylcyclohexanol；3e-5,5-Trimethylcyclohexanol；(1S,5R)-3,3,5-trimethylcyclohexan-1-ol
• CAS: 147332-78-3
• 化学式: C₉H₁₈O
• mdl: MFCD30479494
• 分子量: 142.241
• InChiKey: BRRVXFOKWJKTGG-YUMQZZPRSA-N

物化性质

• 沸点：
  187.7±8.0 °C(Predicted)
• 密度：
  0.878±0.06 g/cm3(Predicted)
• 保留指数：
  1119

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,3,5c-trimethyl-cyclohexan-r-ol 生成 甲基反式-3,3,5-三甲基环己基碳酸酯
  参考文献：
  名称：

  Cycloalkyl carbonates

  摘要：

  公式为## STR1 ##的碳酸酯，其中R.sub.1是从烷基环己基、烯烃基环己基、炔烃基环己基和环烷基组成的群体中选择的具有8至12个碳原子的成员，R.sub.2是从具有1至5个碳原子的烷基、具有2至5个碳原子的烯烃基和具有2至5个碳原子的炔烃基组成的群体中选择的成员，这些化合物具有愉悦和持久的香味，以及生产它们的过程和含有它们的香水组合物。

  公开号：

  US04033993A1
• 作为产物：
  描述：

  3,3,5-三甲基环己酮 在 phosphate buffer 、 Fermipan(R) Red 作用下， 反应 48.0h， 生成 (S)-3,3,5-trimethylcyclohexanone 、 trans-3,3,5-trimethylcyclohexanol 、 3,3,5c-trimethyl-cyclohexan-r-ol 、 (R)-3,3,5-trimethylcyclohexanone
  参考文献：
  名称：

  Stereoselectivity and Substrate Specificity in the Kinetic Resolution of Methyl-Substituted 1-Oxaspiro[2.5]octanes by Rhodotorula glutinis Epoxide Hydrolase

  摘要：

  [GRAPHICS]The kinetic resolution of a range of methyl-substituted 1-oxaspiro[2.5]octanes by yeast epoxide hydrolase (YEH) from Rhodotorula glutinis has been investigated. The structural determinants of substrate specificity and stereoselectivity of YEH toward these substrates appeared to be the configuration of the epoxide ring and the substitution pattern of the cyclohexane ring. For all compounds tested, O-axial epoxides were hydrolyzed faster than the corresponding O-equatorial compounds. In concern of the ring substituents,.YEH preferred methyl groups on the Re side of the ring. Placement of substituents close to the spiroepoxide carbon decreased the reaction rate but increased enantioselectivity. YEH-catalyzed kinetic resolutions of 4-methyl 1-oxaspiro [2.5] octane epimers were most enantioselective,(E > 100).

  DOI：

  10.1021/jo050533w

文献信息

• [EN] 2-AMINOQUINOLINES AS MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS<br/>[FR] 2-AMINOQUINOLINES SERVANT D'ANTAGONISTES DE RECEPTEUR DE L'HORMONE DE CONCENTRATION DE MELANINE
  申请人：ABBOTT LAB

  公开号：WO2003105850A1

  公开（公告）日：2003-12-24

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

  本发明涉及公式(I)的化合物，或其治疗上适用的盐或前药，这些化合物通过黑素浓集激素受体拮抗黑素浓集激素（MCH）的效果，并且用于预防或治疗进食障碍、体重增加和肥胖。
• Process for producing vinyl ether compounds
  申请人：——

  公开号：US20030083529A1

  公开（公告）日：2003-05-01

  A process produces vinyl ether compounds and includes allowing a vinyl ester compound represented by following Formula (1): 1 wherein R 1 , R 2 , R 3 and R 4 are the same or different and are each a hydrogen atom or an organic group, to react with a hydroxy compound represented by following Formula (2): R 5 OH  (2) wherein R 5 is an organic group, in the presence of at least one transition element compound to thereby yield a vinyl ether compound represented by following Formula (3): 2 wherein R 2 , R 3 , R 4 and R 5 have the same meanings as defined above. Such transition element compounds include iridium compounds and other compounds containing Group VIII elements.

  该过程生产乙烯醚化合物，包括使得由以下化学式（1）表示的乙烯酯化合物发生反应：其中R1、R2、R3和R4相同或不同，每个都是氢原子或有机基团，与由以下化学式（2）表示的羟基化合物反应：其中R5是有机基团，在至少一种过渡元素化合物存在下，从而产生由以下化学式（3）表示的乙烯醚化合物：其中R2、R3、R4和R5的含义与上述定义相同。这样的过渡元素化合物包括铱化合物和其他含有第VIII族元素的化合物。
• 3,3,5-trimethylcyclohexyl 2-methylpropionate derivatives, their method
  申请人：Panmedica

  公开号：US05310757A1

  公开（公告）日：1994-05-10

  Derivatives of 3,3,5-trimethylcyclohexanol methyl-2-propionate, preparation method, and therapeutical compositions containing them. Such derivatives have general formula (I). ##STR1##

  3,3,5-三甲基环己醇甲基-2-丙酸酯的衍生物，其制备方法以及含有它们的治疗组合物。这些衍生物具有一般式(I)。 ##STR1##
• 2-Aminoquinolines as melanin concentrating hormone receptor antagonists
  申请人：——

  公开号：US20040063756A1

  公开（公告）日：2004-04-01

  The present invention is related to compounds of formula (I), 1 or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

  本发明涉及式(I)的化合物，或其治疗上适宜的盐或前药，通过黑素浓集激素受体拮抗黑素浓集激素（MCH）的作用，并且对于预防或治疗进食障碍、体重增加和肥胖症是有用的。
• THERMOPLASTIC RESIN COMPOSITION, WATER-BASED COMPOSITION, HEAT-SENSITIVE PRESSURE-SENSITIVE ADHESIVE, AND HEAT-SENSITIVE SHEET
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP0989162A1

  公开（公告）日：2000-03-29

  The thermoplastic resin composition of the present invention, which is a thermoplastic resin composition containing a thermoplastic resin and a solid plasticizer, is characterized in that the solid plasticizer is at least one compound selected from the group of three kinds of compounds (i) a multiester compound of (A) (A1) an alcohol having a substituted cyclohexane ring or a substituted cyclohexene ring substituted by at least one of an alkyl group and having at least 3 carbons in the alkyl group, or (A2) an alcohol having a bridged ring containing at least one of a six-membered carbon ring with (B) a polybasic acid, (iia) a phosphorus compound having a melting point of 55 to 100°C, etc., and (iiia) a diester compound of (C) (c1) hydroquinone or lesorcinol wherein benzene ring may be substituted by an alkyl group, or (c2) catechol wherein benzene ring is substituted by an alkyl group with (D) an organic monobasic acid. Further, the thermoplastic resin composition of the present invention is high in safeness to human genital organs. The thermoplastic resin composition can be employed as a thermally- and pressure-sensitive adhesive, and there can be obtained a thermally- and pressure-sensitive adhesive sheet having an excellent blocking resistance by coating it over a base material sheet.

  本发明的热塑性树脂组合物是一种含有热塑性树脂和固体增塑剂的热塑性树脂组合物，其特征在于固体增塑剂至少是一种选自以下三类化合物的化合物 (i) (A)的多元酯化合物 (A1)具有取代环己烷环或被至少一个烷基取代的取代环己烯环且烷基中至少有 3 个碳的醇、(A1) 具有至少一个烷基且烷基中至少有 3 个碳的取代环己烷环或取代环己烯环的醇，或 (A2) 具有至少一个六元碳环的桥环的醇，且桥环中含有 (B) 多基酸、(iia) 熔点为 55 至 100°C 的磷化合物等。,和(iiia)(C)(c1)对苯二酚或间苯二酚（其中苯环可被烷基取代）或(c2)邻苯二酚（其中苯环被烷基取代）与(D)有机单碱基酸的二酯化合物。此外，本发明的热塑性树脂组合物对人体生殖器官的安全性高。本发明的热塑性树脂组合物可用作热敏和压敏粘合剂，通过在基材板材上涂覆本发明的热敏和压敏粘合剂，可获得抗阻塞性极佳的热敏和压敏粘合剂板材。