2-Butyl-3,3-dimethylbicyclo[2.2.1]heptan-2-ol | 37710-45-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-Butyl-3,3-dimethylbicyclo[2.2.1]heptan-2-ol
• 英文别名: 2-butyl-3,3-dimethylbicyclo[2.2.1]heptan-2-ol
• CAS: 37710-45-5
• 化学式: C₁₃H₂₄O
• 分子量: 196.333
• InChiKey: QCAOXOLQTFLTBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  正丁基锂 、 3,3-二甲基二环[2.2.1]庚烷-2-酮 以 正己烷 为溶剂， 生成 2-Butyl-3,3-dimethylbicyclo[2.2.1]heptan-2-ol
  参考文献：
  名称：

  Reaction of lithium alkyls with aldehydes and ketones. General study

  摘要：

  DOI：

  10.1021/jo00945a012

文献信息

• [EN] DERIVATIVES OF MECAMYLAMINE<br/>[FR] DÉRIVÉS DE MÉCAMYLAMINE
  申请人：PROVOST FELLOWS & SCHOLARS COLLEGE OF THE HOLY UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

  公开号：WO2013026852A2

  公开（公告）日：2013-02-28

  Mecamylamine is a general nicotinic acetylcholine receptor (nAChR) antagonist that was one of the first anti-hypertensive agents. Since its demise as an anti-hypertensive drug, mecamylamine has been shown to aid smoking cessation (in humans), reduce cue induced craving in human cocaine addicts and heavy drinkers. The present invention provides for novel derivatives of mecamylamine and inventive synthetic routes to these compounds.
• Reaction of lithium alkyls with aldehydes and ketones. General study
  作者：Jerry D. Buhler

  DOI：10.1021/jo00945a012

  日期：1973.3