烟醇酒石酸盐 | 6164-87-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 烟醇酒石酸盐
• 中文别名: 烟碱醇酒石酸盐；烟碱醇酒石酸酯
• 英文名称: Nicotinyl alcohol tartrate
• 英文别名: (2R,3R)-2,3-dihydroxybutanedioic acid;pyridin-3-ylmethanol
• CAS: 6164-87-0
• 化学式: C10H13NO7
• 分子量: 259.21
• InChiKey: NPORIZAYKBQYLF-LREBCSMRSA-N

物化性质

• 熔点：
  147-148°
• 碰撞截面：
  119.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

• 辛醇/水分配系数(LogP)：
  -1.55
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  148
• 氢给体数：
  5
• 氢受体数：
  8

安全信息

• WGK Germany：
  3

文献信息

• SUBSTITUTED BIPIPERIDINYL DERIVATIVES
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US20160318866A1

  公开（公告）日：2016-11-03

  The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

  该发明涉及新型取代的双哌啶衍生物，涉及它们的制备方法，涉及它们用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防糖尿病微血管病变、四肢糖尿病溃疡，特别是促进糖尿病足溃疡愈合、糖尿病心力衰竭、糖尿病冠状微血管心脏疾病、外周和心脏血管疾病、血栓栓塞疾病和缺血、外周循环障碍、雷诺现象、CREST综合征、微循环障碍、间歇性跛行以及外周和自主神经病变的治疗和/或预防。
• PRODRUGS AND THE USE THEREOF
  申请人：Diedrichs Nicole

  公开号：US20120122820A1

  公开（公告）日：2012-05-17

  The present application relates to prodrug derivatives of 2-amino-6-([2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.

  本申请涉及2-氨基-6-([2-(4-氯苯基)-1,3-噻唑-4-基]甲基}硫)-4-[4-(2-羟乙氧基)苯基]吡啶-3,5-二氰基的前药衍生物，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制造用于治疗和/或预防疾病的药物，特别是心血管疾病。
• AMINO ACID ESTER PRODRUGS AND THE USE THEREOF
  申请人：Meibom Daniel

  公开号：US20110237629A1

  公开（公告）日：2011-09-29

  The present application relates to amino acid ester prodrug derivatives of 2-amino-6-([2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitriles, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.

  本申请涉及2-氨基-6-([2-(4-氯苯基)-1,3-噁唑-4-基]甲基}硫基)-4-(4-[2,3-二羟基丙基]氧基}苯基)吡啶-3,5-二羧腈的氨基酸酯前药衍生物，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制造用于治疗和/或预防疾病的药物，特别是心血管疾病。
• MODIFIED RELAXIN POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCER AND USES THEREOF
  申请人：Bristol-Myers Squibb Company

  公开号：US20180222960A1

  公开（公告）日：2018-08-09

  The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

  本公开涉及改良的Relaxin多肽，例如改良的人类Relaxin 2多肽，包括与药代增强剂相连的非自然编码氨基酸，并且这些多肽的治疗用途，例如用于治疗心血管疾病（如心力衰竭）和/或与纤维化相关的疾病。
• NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS
  申请人：Nell Peter

  公开号：US20100093728A1

  公开（公告）日：2010-04-15

  The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

  本发明涉及新型取代的2,4′-和3,4′-联吡啶衍生物，涉及它们的制备方法，涉及它们用于治疗和/或预防疾病的用途，以及涉及它们用于制备用于治疗和/或预防疾病的药物，优选用于治疗和/或预防高血压和其他心血管疾病。