2-(1-ethyl-propoxy)-ethanol | 89910-58-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1-ethyl-propoxy)-ethanol
• 英文别名: Pentanol-(3)-(2-hydroxy-aethylaether)；2-(1-Aethyl-propoxy)-aethanol；2-(1-ethylpropoxy)ethanol；2-Hydroxy-1-<1-aethyl-propyl-(1)-oxy>-aethan；2-(Pentan-3-yloxy)ethan-1-ol；2-pentan-3-yloxyethanol
• CAS: 89910-58-7
• 化学式: C₇H₁₆O₂
• 分子量: 132.203
• InChiKey: MZXGXWPUTAHLFU-UHFFFAOYSA-N

物化性质

• 沸点：
  172.6 °C(Press: 746.4 Torr)
• 密度：
  0.9151 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-戊醇 在 palladium 10% on activated carbon 氢气 、 sodium hydride 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.25h， 生成 2-(1-ethyl-propoxy)-ethanol
  参考文献：
  名称：

  [EN] ETHER DERIVATIVES OF BICYCLIC HETEROARYLS
  [FR] DÉRIVÉS ÉTHERS D'HÉTÉROARYLES BICYCLIQUES

  摘要：

  这项发明涉及到式(I)的化合物，其中取代基如规范中所定义；制备这种化合物的方法；包含这种化合物的药物组合物；这种化合物作为药物；这种化合物用于治疗增殖性疾病。

  公开号：

  WO2011029915A1

文献信息

• PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF
  申请人：MIURA Tomoya

  公开号：US20130085132A1

  公开（公告）日：2013-04-04

  The present invention provides a pyrazole compound of the following general Formula [Ib] having SGLT1 inhibitory activity, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and its pharmaceutical use: wherein each symbol is the same as defined in the description.

  本发明提供了一种具有SGLT1抑制活性的下式[Ib]所示的吡唑化合物、或其药物可接受的盐、包含该化合物的药物组合物及其医药用途： 其中每个符号如说明书中所定义。
• 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE
  申请人：Sekiguchi Yoshinori

  公开号：US20100081825A1

  公开（公告）日：2010-04-01

  Disclosed is a pharmaceutical composition comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, which has an antagonistic activity on a melanin-concentrating hormone receptor. The pharmaceutical composition is useful, due to its antagonistic activity on a MCH receptor, for the prevention or treatment of a disease such as depression, anxiety disorders (e.g., generalized anxiety disorder, post traumatic stress disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder), attention deficit disorder, mania, manic-depressive disorder, schizophrenia, mood disorders, stress, sleep disorder, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, a cardiovascular diseases, hypertension, dyslipidemia, cardiac infarction, movement disorder (e.g., Parkinson's disease, epilepsy, convulsion, tremor), drug abuse and drug addiction.

  本发明揭示了一种药物组合物，其包括一种由式(I)表示的化合物或其药学上可接受的盐作为活性成分，该化合物具有对黑色素浓集激素受体的拮抗活性。该药物组合物由于其对MCH受体的拮抗活性，可用于预防或治疗抑郁症、焦虑障碍（例如广泛性焦虑症、创伤后应激障碍、恐慌症、强迫症、社交焦虑症）、注意力缺陷障碍、躁狂、躁郁症、精神分裂症、情绪障碍、压力、睡眠障碍、发作、记忆障碍、认知障碍、痴呆、健忘症、谵妄、肥胖症、进食障碍、食欲障碍、过度进食、暴食症、食物恐惧症、糖尿病、心血管疾病、高血压、脂质代谢异常、心肌梗塞、运动障碍（例如帕金森病、癫痫、抽搐、震颤）、药物滥用和药物成瘾等疾病的预防或治疗。
• ETHER DERIVATIVES OF BICYCLIC HETEROARYLS
  申请人：Chen Bei

  公开号：US20120165310A1

  公开（公告）日：2012-06-28

  The invention relates to compounds of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; such compounds as a medicament; such compounds for the treatment of a proliferative disease.

  本发明涉及式I的化合物，其中取代基如规范中所定义；制备此类化合物的方法；包含此类化合物的制药组合物；此类化合物作为药物；此类化合物用于治疗增生性疾病。
• Modified Polyamide Resin with Heat Resistance, Moldability and Whiteness and Method for Preparing the Same Using Polyester Resin
  申请人：Cheil Industries Inc.

  公开号：EP2607402A2

  公开（公告）日：2013-06-26

  A modified polyamide resin includes repeating units derived from dicarboxylic acid; and repeating units derived from aliphatic saturated diamines in its chain. The repeating units derived from aliphatic saturated diamines includes repeating units derived from an aliphatic saturated C2 to C6 diamine and from an aliphatic saturated C6 to C12 diamine which is different from the aliphatic saturated C2 to C6 diamine.

  改性聚酰胺树脂包括二羧酸衍生的重复单元；以及其链中脂肪族饱和二胺衍生的重复单元。由脂肪族饱和二胺衍生的重复单元包括由脂肪族饱和 C2 至 C6 二胺衍生的重复单元和由脂肪族饱和 C6 至 C12 二胺衍生的重复单元，后者不同于脂肪族饱和 C2 至 C6 二胺。
• PYRAZOLE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：Japan Tobacco, Inc.

  公开号：EP2784074A1

  公开（公告）日：2014-10-01

  A compound of the following general Formula [Ib]: , wherein each symbol is the same as defined in the description; or a pharmaceutically acceptable salt thereof.

  以下通式[Ib]的化合物： 其中各符号与描述中定义的相同；或其药学上可接受的盐。