烯丙基-1,1,2,2-四氟乙基醚 | 1428-33-7

• 物质功能分类: 化学试剂 - 有机试剂 - 烯烃（环状与无环状）
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 烯丙基-1,1,2,2-四氟乙基醚
• 中文别名: 四氟丙烯酸乙酯
• 英文名称: 1,1,2,2-tetrafluoroethyl allyl ether
• 英文别名: 2H-Perfluoroethyl allyl ether；allyl-(1,1,2,2-tetrafluoro-ethyl)-ether；Allyl-(1,1,2,2-tetrafluor-aethyl)-aether；1,1,2,2-tetrafluorethylpropen(2)-1-yl-ether；3-(1,1,2,2-tetrafluoroethoxy)propene；HCF2CF2OCH2CH=CH2；Allyl 1,1,2,2-tetrafluoroethyl ether；3-(1,1,2,2-tetrafluoroethoxy)prop-1-ene
• CAS: 1428-33-7
• 化学式: C₅H₆F₄O
• mdl: MFCD00043822
• 分子量: 158.096
• InChiKey: DTDFWYZVBJYVPL-UHFFFAOYSA-N

物化性质

• 沸点：
  76-78°C
• 密度：
  1,2 g/cm3
• 闪点：
  -5°C
• 大气OH速率常数：
  1.90e-11 cm3/molecule*sec

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 危险等级：
  3.1
• 危险品标志：
  F,Xn
• 危险类别码：
  R20/22,R11
• 危险品运输编号：
  UN 3271
• 海关编码：
  2909199090
• 包装等级：
  II
• 危险类别：
  3.1
• 安全说明：
  S16,S23,S33

SDS

Name:	Allyl 1 1 2 2-tetrafluoroethyl ether 99% Material Safety Data Sheet
Synonym:	Non
CAS:	1428-33-7

Section 1 - Chemical Product MSDS Name:Allyl 1 1 2 2-tetrafluoroethyl ether 99% Material Safety Data Sheet
Synonym:Non

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1428-33-7	Allyl 1,1,2,2-Tetrafluoroethyl ether	99%	215-847-3

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
Inhalation:
The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use dry sand or earth to smother fire. Use water spray to cool fire-exposed containers.
Autoignition Temperature: Not available.
Flash Point: Not available.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Use only in a chemical fume hood.
Storage:
Keep away from heat, sparks, and flame. Store in a cool, dry place.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local, explosion-proof ventilation to keep airborne levels to acceptable levels.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Not available.
Appearance: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Decomposition Temperature: Not available.
Solubility: Not available.
Specific Gravity/Density: Not available.
Molecular Formula: Not available.
Molecular Weight: Not available.

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Has not been fully evaluated.
Conditions to Avoid:
Light, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1428-33-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Allyl 1,1,2,2-Tetrafluoroethyl ether - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION
For further information, contact Fisher Scientific.

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

CDG/CPL
IMO
Not regulated as a hazardous material.
IATA
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
Canadian TDG
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 1428-33-7:
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
WHMIS: Not available.
CAS# 1428-33-7 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 1428-33-7 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  烯丙基-1,1,2,2-四氟乙基醚 在 dihydrogen hexachloroplatinate 二氯硅烷 作用下， 生成 Dichlor-<3-(1,1,2,2-tetrafluor-aethoxy)-propyl>-silan
  参考文献：
  名称：

  Ponomarenko,V.A. et al., Journal of applied chemistry of the USSR, 1960, vol. 33, p. 2714 - 2720

  摘要：

  DOI：
• 作为产物：
  描述：

  四氟乙烯 、 烯丙醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 生成 烯丙基-1,1,2,2-四氟乙基醚
  参考文献：
  名称：

  作为眼镜蛇毒磷脂酶 A2 抑制剂的磷脂类似物的合成和评价

  摘要：

  Synthese d'analogues de phosphatidylcholine ou le groupe situen en 2 est remplace par des oxo-2alkane ou des hydroxy-2烷基

  DOI：

  10.1021/ja00260a020

文献信息

• Process for preparing fluoroalkyl-containing organosilicon compounds,
  申请人：Huels Aktiengesellschaft

  公开号：US05869728A1

  公开（公告）日：1999-02-09

  Fluoroalkyl organosilicon compounds are prepared by reacting fluoroolefins with organosilicon compounds that contain at least one H--Si group, in the presence of a Pt(0) complex catalyst. Further, fluoroalkylalkoxy organosilicon compounds are prepared by esterifying fluoroalkyl organosilicon compounds. The process proceeds uniformly under mild conditions with high yields and selectivities.

  氟烷基有机硅化合物是通过在Pt（0）复合催化剂存在下，将含有至少一个H-Si基团的有机硅化合物与氟烯烃反应制备而成。此外，通过酯化氟烷基有机硅化合物，可以制备氟烷基烷氧基有机硅化合物。该过程在温和条件下均匀进行，产率和选择性高。
• Kinetic Study for the Reactions of Several Hydrofluoroethers with Chlorine Atoms
  作者：Vassileios C. Papadimitriou、Kyriakos G. Kambanis、Yannis G. Lazarou、Panos Papagiannakopoulos

  DOI：10.1021/jp031081z

  日期：2004.4.1

  Arrhenius expressions for the studied reactions are (in cm3 molecule-1 s-1, 2σ uncertainties):  k1 = (5.49 ± 1.51) × 10-12 exp(−928 ± 155/T), k2 = (1.99 ± 0.12) × 10-12 exp(−36 ± 33/ T), k3 = (1.95 ± 0.72) × 10-12 exp(−1616 ± 202/T), k4 = (8.72 ± 2.93) × 10-12 exp(−1112 ± 186/T), and k5 = (5.54 ± 1.96) × 10-13 exp(821 ± 214/T). The title reactions proceed via hydrogen atom metathesis, with the exception of

  氯原子与氢氟醚 CHF2CF2OCH3 (1)、CHF2CF2OCH2CH3 (2)、CHF2CF2OCH2CF3 (3)、CF3CHFCF2OCH3 (4) 和 CH2CHCH2OCF2CHF2 (5) 的反应动力学在 273-363 K 温度范围内的气相中进行了研究。通过监测两种反应物，在配备有四极质谱仪的分子流系统中，在非常低的压力 (<3 mTorr) 下进行了实验。所研究反应的建议 Arrhenius 表达式为（cm3 分子-1 s-1，2σ 不确定性）：k1 = (5.49 ± 1.51) × 10-12 exp(-928 ± 155/T), k2 = (1.99 ± 0.12 ) × 10-12 exp(-36 ± 33/T), k3 = (1.95 ± 0.72) × 10-12 exp(-1616 ± 202/T), k4 = (8.72 ± 2.93) × 10-12 exp(-
• Preparative Flow Techniques; 1. Low-Temperature Organometallic Reactions: Synthesis of Ethyl 2,2-Difluoro-4-pentenoate
  作者：Michael Kolb、Fritz Gerhart、Jean-Paul François

  DOI：10.1055/s-1988-27608

  日期：——

  A convenient preparation of the synthetically useful ethyl 2,2-difluoro-4-pentenoate using the low-temperature flow technique is described. The method is suitable for small-scale as well as for large-scale application.

  本文介绍了使用低温流动技术合成有用的2,2-二氟-4-戊烯酸乙酯的便捷方法。该方法适用于小规模以及大规模应用。
• Monakhova,A.T. et al., Journal of Organic Chemistry USSR (English Translation), 1969, vol. 5, p. 1884 - 1887
  作者：Monakhova,A.T. et al.

  DOI：——

  日期：——
• Cyclizations of 5-Hexenyl, 6-Heptenyl, 7-Octenyl, and 8-Nonenyl Radicals. The Kinetic and Regiochemical Impact of Fluorine and Oxygen Substituents
  作者：Anrong Li、Alexander B. Shtarev、Bruce E. Smart、Zhen-Yu Yang、Janusz Lusztyk、Keith U. Ingold、Anna Bravo、William R. Dolbier

  DOI：10.1021/jo990544n

  日期：1999.8.1

  Using competition kinetic methodology, rate constants for cyclizations of a series of hydrofluorocarbon (HFC) and ether 5-hexenyl, 6-heptenyl, and 7-octenyl radicals have been determined. Remarkably large rate constants (>10(7) s(-1)) have been observed for 6-exo-cyclizations of 1,1,2,2-tetrafluoro- and 1,1,2,2,3,3,4,4,-octafluoro-6-heptenyl radicals (>10(3) those of analogous hydrocarbon radicals), whereas HFC hexenyl and heptenyl ethers exhibit lower cyclization reactivity, as do HFC 7-octenyl radical systems, which cyclize in an endo manner. HFC 8-nonenyl radicals were not observed to cyclize. The results can be rationalized in terms of transition state polar influences, though other factors may also play significant roles.