tri-tert-butyl 2,2',2"-(10-(4-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate | 607706-70-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tri-tert-butyl 2,2',2"-(10-(4-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
• 英文别名: Tert-butyl 2-[4,7-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-10-[(4-nitrophenyl)methyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate
• CAS: 607706-70-7
• 化学式: C₃₃H₅₅N₅O₈
• 分子量: 649.828
• InChiKey: IADARNZWAYHSRU-UHFFFAOYSA-N

物化性质

• 沸点：
  677.3±55.0 °C(Predicted)
• 密度：
  1.103±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  138
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  tri-tert-butyl 2,2',2"-(10-(4-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate 在 palladium 10% on activated carbon 、 氢气 、 三氟乙酸 作用下， 以 甲醇 为溶剂， 反应 60.0h， 生成 1,4,7-tris(carboxymethyl)-10-<(4-aminophenyl)methyl>-1,4,7,10-tetraazacyclodecane
  参考文献：
  名称：

  化合物、试剂盒、及用作光磁双模态探针的用途

  摘要：

  本申请涉及一种式(I)的化合物，涉及式(I)化合物的制备方法，涉及包含式(I)化合物的试剂盒，以及涉及用作光磁双模态探针的用途

  公开号：

  CN115785117A
• 作为产物：
  描述：

  对硝基溴化苄 在 sodium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 5.0h， 生成 tri-tert-butyl 2,2',2"-(10-(4-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
  参考文献：
  名称：

  荧光稀土络合标记物及其制备和用其进行时间分辨荧光分析的方法与试剂盒

  摘要：

  一种新型荧光稀土络合标记物及其制备和用其进行时间分辨荧光分析的方法与试剂盒，该类络合标记物可通过采用化学修饰的功能性基团与蛋白质、多肽、激素等生物分子进行共价结合，进而对各种微量生物活性物质进行时间分辨荧光测定；与常规荧光标记物相比，具有高荧光强度、稳定性、容易标记且成本低、制备简单的特点；与现有技术中的络合标记物相比，具有灵敏度高，成本较低，标记率高，使用范围广泛等优点。

  公开号：

  CN110950817A

文献信息

• Compounds Comprising a Biological Target Recognizing Part, Coupled to a Signal Part Capable of Complexing Gallium
  申请人：Port Marc

  公开号：US20110092806A1

  公开（公告）日：2011-04-21

  The invention concerns compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium. The invention also concerns methods for obtaining said compounds, screening methods capable of selecting such compounds for chemical synthesis thereof and their diagnostic applications, in particular in PET, PET/IRM, PET CT imaging.

  本发明涉及化合物，包括生物靶标识别部分和能够与镓形成配合物的信号部分。本发明还涉及获得这些化合物的方法，筛选方法能够选择这些化合物进行化学合成以及它们的诊断应用，特别是在PET、PET/IRM、PET CT成像中。
• Lanthanide-Based Protease Activity Sensors for Time-Resolved Fluorescence Measurements
  作者：Shin Mizukami、Kazuhiro Tonai、Masahiro Kaneko、Kazuya Kikuchi

  DOI：10.1021/ja800322b

  日期：2008.11.5

  Lanthanide-based luminescent sensors are noteworthy because their long-lifetime luminescence enables time-resolved fluorescence measurements. After exploring suitable antenna groups, we designed and synthesized lanthanide-based luminogenic sensors detecting protease activities. This sensor yielded strong luminescence on addition of proteases such as calpain I and leucine aminopeptidase (LAP). Since the luminescence lifetimes of the probes were very long, the sensors could be applied to time-resolved measurements that exclude background fluorescence signals derived from protiens or other impurities. This sensing principle could be applicable to general time-resolved fluorescence assays for other proteases.
• Lanthanide-Sensitized Lanthanide Luminescence:  Terbium-Sensitized Ytterbium Luminescence in a Trinuclear Complex
  作者：Stephen Faulkner、Simon J. A. Pope

  DOI：10.1021/ja035634v

  日期：2003.9.1

  A heterotrinuclear lanthanide complex has been prepared which contains two terbium ions in DO3A-derived binding sites and a single ytterbium ion in a DTPA-like site. The luminescence properties of the system have been investigated, showing that the terbium remains in a seven-coordinate binding site throughout the synthesis, while the ytterbium occupies the eight-coordinate site. Pumping the 488 nm absorption band of the terbium ion results in energy transfer to ytterbium with emission at 980 nm.
• COMPOSES COMPRENANT UNE PARTIE DE RECONNAISSANCE D'UNE CIBLE BIOLOGIQUE, COUPLEE A UNE PARTIE DE SIGNAL CAPABLE DE COMPLEXER LE GALLIUM
  申请人：GUERBET

  公开号：EP1940841B1

  公开（公告）日：2016-12-07
• ENCAPSULATING SYSTEM FOR CEST IMAGING WITH CHELATE Q GREATER THAN OR EQUAL TO 2
  申请人：Port Marc

  公开号：US20110243859A1

  公开（公告）日：2011-10-06

  The present invention relates to the use of a CEST contrast agent in a method of CEST imaging, wherein the contrast agent is a composition comprising an encapsulating system ES encapsulating at least one CEST agent, wherein the at least one CEST agent is constituted of a monomeric chelate of a chelate of q≧2 type, or of a multimer of monomeric chelates of q≧2 type, and wherein said chelate is free inside the encapsulating system.