1,4,7-tris(tert-butoxycarbonylmethyl)-10-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane | 607706-71-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,4,7-tris(tert-butoxycarbonylmethyl)-10-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane
• 英文别名: 4-aminobenzyl DO3A tert-butyl ester；Tert-butyl 2-[4-[(4-aminophenyl)methyl]-7,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate
• CAS: 607706-71-8
• 化学式: C₃₃H₅₇N₅O₆
• 分子量: 619.845
• InChiKey: FQGSSRYSCDSFPC-UHFFFAOYSA-N

物化性质

• 沸点：
  669.7±55.0 °C(Predicted)
• 密度：
  1.070±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  44
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  1,4,7-tris(tert-butoxycarbonylmethyl)-10-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane 在 三氟乙酸 作用下， 以99 %的产率得到1,4,7-tris(carboxymethyl)-10-<(4-aminophenyl)methyl>-1,4,7,10-tetraazacyclodecane
  参考文献：
  名称：

  化合物、试剂盒、及用作光磁双模态探针的用途

  摘要：

  本申请涉及一种式(I)的化合物，涉及式(I)化合物的制备方法，涉及包含式(I)化合物的试剂盒，以及涉及用作光磁双模态探针的用途

  公开号：

  CN115785117A
• 作为产物：
  描述：

  tri-tert-butyl 2,2',2"-(10-(4-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以99 %的产率得到1,4,7-tris(tert-butoxycarbonylmethyl)-10-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane
  参考文献：
  名称：

  化合物、试剂盒、及用作光磁双模态探针的用途

  摘要：

  本申请涉及一种式(I)的化合物，涉及式(I)化合物的制备方法，涉及包含式(I)化合物的试剂盒，以及涉及用作光磁双模态探针的用途

  公开号：

  CN115785117A

文献信息

• Reductive Amination - A Convenient Method for Generating Diverse, Mono-Functionalised 5,10,15,20-Tetraphenyl Porphyrins
  作者：Stephen Archibald、Ross Boyle、Chris Welch

  DOI：10.1055/s-0028-1083335

  日期：2009.2

  Formylation followed by reductive amination of 5,10,15,20-tetraphenyl porphyrin (TPP) is shown to be a versatile synthetic procedure for monosubstitution of the porphyrin core regiospecifically at one β-position. A diverse range of substituents can be introduced in this way in good yields, including cyclen aza-crown macrocycles. porphyrin - substitution - cyclen - amination - regioselective

  甲酰化后再进行5,10,15,20-四苯基卟啉（TPP）的还原胺化反应是一种通用的合成方法，可在一个β位上将卟啉核心区域特异性地单取代。可以这种方式以高收率引入各种范围的取代基，包括环烷氮杂-皇冠大环。 卟啉-取代-循环-胺化-区域选择性
• Compounds Comprising a Biological Target Recognizing Part, Coupled to a Signal Part Capable of Complexing Gallium
  申请人：Port Marc

  公开号：US20110092806A1

  公开（公告）日：2011-04-21

  The invention concerns compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium. The invention also concerns methods for obtaining said compounds, screening methods capable of selecting such compounds for chemical synthesis thereof and their diagnostic applications, in particular in PET, PET/IRM, PET CT imaging.

  本发明涉及化合物，包括生物靶标识别部分和能够与镓形成配合物的信号部分。本发明还涉及获得这些化合物的方法，筛选方法能够选择这些化合物进行化学合成以及它们的诊断应用，特别是在PET、PET/IRM、PET CT成像中。
• Lanthanide-Based Protease Activity Sensors for Time-Resolved Fluorescence Measurements
  作者：Shin Mizukami、Kazuhiro Tonai、Masahiro Kaneko、Kazuya Kikuchi

  DOI：10.1021/ja800322b

  日期：2008.11.5

  Lanthanide-based luminescent sensors are noteworthy because their long-lifetime luminescence enables time-resolved fluorescence measurements. After exploring suitable antenna groups, we designed and synthesized lanthanide-based luminogenic sensors detecting protease activities. This sensor yielded strong luminescence on addition of proteases such as calpain I and leucine aminopeptidase (LAP). Since the luminescence lifetimes of the probes were very long, the sensors could be applied to time-resolved measurements that exclude background fluorescence signals derived from protiens or other impurities. This sensing principle could be applicable to general time-resolved fluorescence assays for other proteases.
• Lanthanide-Sensitized Lanthanide Luminescence:  Terbium-Sensitized Ytterbium Luminescence in a Trinuclear Complex
  作者：Stephen Faulkner、Simon J. A. Pope

  DOI：10.1021/ja035634v

  日期：2003.9.1

  A heterotrinuclear lanthanide complex has been prepared which contains two terbium ions in DO3A-derived binding sites and a single ytterbium ion in a DTPA-like site. The luminescence properties of the system have been investigated, showing that the terbium remains in a seven-coordinate binding site throughout the synthesis, while the ytterbium occupies the eight-coordinate site. Pumping the 488 nm absorption band of the terbium ion results in energy transfer to ytterbium with emission at 980 nm.
• COMPOSES COMPRENANT UNE PARTIE DE RECONNAISSANCE D'UNE CIBLE BIOLOGIQUE, COUPLEE A UNE PARTIE DE SIGNAL CAPABLE DE COMPLEXER LE GALLIUM
  申请人：GUERBET

  公开号：EP1940841B1

  公开（公告）日：2016-12-07