3-Isopropyloxetan-2-one | 25250-54-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-Isopropyloxetan-2-one
• 英文别名: beta-Isopropyl-beta-propiolactone；3-propan-2-yloxetan-2-one
• CAS: 25250-54-8
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: JFLMBMOAMWVCRC-UHFFFAOYSA-N

物化性质

• 沸点：
  163.8±9.0 °C(Predicted)
• 密度：
  1.031±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Isopropyloxetan-2-one 在 sodium hydrogensulfide 作用下， 以 乙醇 为溶剂， 生成 3-甲基-2-(硫烷基甲基)丁酸
  参考文献：
  名称：

  Cignarella,G. et al., Farmaco, Edizione Scientifica, 1963, vol. 18, p. 907 - 919

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-2-亚甲基-丁酸 在 sodium hydroxide 、 氢溴酸 作用下， 以 氯仿 、 溶剂黄146 为溶剂， 反应 2.0h， 生成 3-Isopropyloxetan-2-one
  参考文献：
  名称：

  Sakai, Naoko; Ageishi, Satoru; Isobe, Hiroshi, Journal of the Chemical Society. Perkin transactions I, 2000, # 1, p. 71 - 78

  摘要：

  DOI：

文献信息

• Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
  申请人：The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone

  公开号：US11376242B2

  公开（公告）日：2022-07-05

  Provided are methods and compositions for identifying candidate agents for treatment of obesity, liver disease, and/or diabetes. Such methods include, e.g., contacting a mammalian cell or cell population with a test agent, and measuring an expression level and/or activity level of ClpP in the mammalian cell or in cells of the cell population. Also provided are methods and compositions for treating an individual (e.g., one who is obese and/or has diabetes). Treatment methods include administering an inhibitor of ClpP to the individual (e.g., to prevent or reduce weight gain, to increase insulin sensitivity, and/or to increase glucose tolerance).

  本文提供了用于鉴定治疗肥胖症、肝病和/或糖尿病的候选药物的方法和组合物。这些方法包括，例如，用测试剂接触哺乳动物细胞或细胞群，并测量哺乳动物细胞或细胞群中 ClpP 的表达水平和/或活性水平。还提供了治疗个体（如肥胖和/或糖尿病患者）的方法和组合物。治疗方法包括给个体施用ClpP抑制剂（例如，防止或减少体重增加、增加胰岛素敏感性和/或增加葡萄糖耐量）。
• METHODS AND COMPOSITIONS FOR TREATING OBESITY AND/OR DIABETES AND FOR IDENTIFYING CANDIDATE TREATMENT AGENTS
  申请人：The J. David Gladstone Institutes

  公开号：EP3429567A1

  公开（公告）日：2019-01-23
• Method for preparing polymers containing cyclopentanone structures
  申请人：IM&T Research, Inc.

  公开号：US20030081432A1

  公开（公告）日：2003-05-01

  A method to electrolytically polymerize aromatic hydrocarbons and oxidize cyclopentane structures within the hydrocarbons into cyclopentanone structures is disclosed including a method to electrolyse fluorene in the presence of an ester to produce poly(9-fluorenone). A method to electrolytically oxidize polymers having cyclopentane structures to polymers having cycloppentanone structures is also disclosed including a method to electrolyze poly(fluorene) to produce poly(9-fluorenone). In addition, a method to chemically oxidize polymers containing cyclopentane structures into polymers containing cyclopentanone structures is disclosed, including a method to oxidize poly(fluorene), with a chemically prepared oxidizing agent, to produce poly(9-fluorenone).
• TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20140243255A1

  公开（公告）日：2014-08-28

  The technology described herein relates to treatments for tuberculosis which target the ClpP1P2 protease complex, including ClpC1. Further embodiments relate to assays and screens for modulators of the ClpP1P2 protease complex, including ClpC1.
• US6835296B2
  申请人：——

  公开号：US6835296B2

  公开（公告）日：2004-12-28