trans-Hexahydro-α-benzosuberon

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-Hexahydro-α-benzosuberon
• 英文别名: (+/-)-trans-decahydro-benzocyclohepten-5-one；(+/-)-trans-Decahydro-benzocyclohepten-5-on；(4aS,9aR)-1,2,3,4,4a,6,7,8,9,9a-decahydrobenzo[7]annulen-5-one
• 化学式: C₁₁H₁₈O
• 分子量: 166.263
• InChiKey: VXKGUFHXCQYSLH-ZJUUUORDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  trans-Hexahydro-α-benzosuberon 在 乙醇 、 铂 作用下， 生成 (+-)-4-nitro-benzoic acid-((4ar,9at)-decahydro-benzocyclohepten-5c(?)-yl ester)
  参考文献：
  名称：

  脂环族研究-X：双环-（5：4：0）-2-十一碳烷

  摘要：

  讨论了双环-（5：4：0）-2-十一烷酮的立体化学。顺式酮是通过苯并亚砜的催化还原而获得的，并通过用甲醇钠处理将其转化为反式酮。描述了两种异构体的脱氢实验。

  DOI：

  10.1016/0040-4020(57)85003-0
• 作为产物：
  描述：

  (+/-)-(4ar,9ac)-decahydro-benzocyclohepten-5t-ol 在 chromium(VI) oxide 、 甲醇 、 sodium methylate 、 溶剂黄146 作用下， 生成 trans-Hexahydro-α-benzosuberon
  参考文献：
  名称：

  脂环族研究-X：双环-（5：4：0）-2-十一碳烷

  摘要：

  讨论了双环-（5：4：0）-2-十一烷酮的立体化学。顺式酮是通过苯并亚砜的催化还原而获得的，并通过用甲醇钠处理将其转化为反式酮。描述了两种异构体的脱氢实验。

  DOI：

  10.1016/0040-4020(57)85003-0

文献信息

• The reaction of cycloalkanes with carbon monoxide
  作者：A.T. Balaban、C.D. Nenitzescu

  DOI：10.1016/0040-4020(60)85007-7

  日期：1960.1

  The condensation of some cycloalkanes with carbon monoxide under pressure, in the presence of AlCl3 at normal or slightly higher temperature has been investigated. Cyclopentane leads to cyclopentanecarboxylic acid. Methylcyclopentane yields the same products as cyclohexane, namely cyclohexanecarboxylic acid and 2-methylcyclohexanone. From methylcyclohexane, cyclohexyl methyl ketone is obtained together

  已经研究了在常温或稍高温度下，在AlCl 3存在下，某些环烷烃在压力下与一氧化碳的缩合反应。环戊烷生成环戊烷羧酸。甲基环戊烷产生与环己烷相同的产物，即环己烷羧酸和2-甲基环己酮。由甲基环己烷可得到环己基甲基酮，以及反式-2-甲基-环己烷甲酸与3-和/或4-甲基异构体的混合物。由十氢化萘制得反式-反式-1-萘烷羧酸和反式-六氢-α-苯并亚砜。讨论了这些反应的机理。
• The Development of the Surgical Treatment of Morbid Obesity
  作者：Mervyn Deitel、Scott A. Shikora

  DOI：10.1080/07315724.2002.10719237

  日期：2002.10

  Morbid obesity is defined as obesity with a body mass index greater than or equal to40, or greater than or equal to35 with secondary serious diseases. Conservative medical therapies in these individuals generally fail to sustain weight loss. Thus, surgical operations have evolved which are based on gastric restriction and/or malabsorption. Historically, the intestinal bypass operation was followed by the gastric bypass operation (in some instances combined with intestinal bypass) or by the gastric restriction operations (gastroplasty or gastric banding), Laparoscopic techniques are now being used for these operations, but require surgical expertise in both the bariatric operations and advanced laparoscopic skills. All operations may have complications, but these occur in a very small percent. Postoperative follow-up and nutritional surveillance are mandatory. The operations result in significant weight loss, and the current operations have a mean lasting weight loss of about 50 percent of excess body weight, with improvement or resolution of most obesity-associated conditions. There is evidence that even modest to moderate weight loss in these individuals has significant medical benefit.
• Alicyclic studies—X
  作者：David Ginsburg、Walter J. Rosenfelder

  DOI：10.1016/0040-4020(57)85003-0

  日期：1957.1

  The stereochemistry of the bicyclo-(5:4:0)-2-undecanones is discussed. The cis-ketone is obtained by catalytic reduction of benzosuberone and is converted into the trans-ketone by treatment with sodium methoxide. Dehydrogenation experiments of both isomers are described.

  讨论了双环-（5：4：0）-2-十一烷酮的立体化学。顺式酮是通过苯并亚砜的催化还原而获得的，并通过用甲醇钠处理将其转化为反式酮。描述了两种异构体的脱氢实验。