1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrole-2-carboxylic acid 4-methoxybenzylamide | 1615684-98-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrole-2-carboxylic acid 4-methoxybenzylamide
• 英文别名: 1-(1-hydroxy-3H-2,1-benzoxaborol-6-yl)-N-[(4-methoxyphenyl)methyl]pyrrole-2-carboxamide
• CAS: 1615684-98-4
• 化学式: C₂₀H₁₉BN₂O₄
• 分子量: 362.193
• InChiKey: SDFGVTJXXROIDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.63
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  72.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-溴-4-硝基苯甲酸 在 盐酸 、 锂硼氢 、 正丁基锂 、 氯化亚砜 、 tin(II) chloride dihdyrate 、 1-羟基苯并三唑 、 silver nitrate 、 1,2-二氯乙烷 、 三乙胺 、 sodium hydroxide 、 三氯氧磷 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 反应 15.25h， 生成 1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)pyrrole-2-carboxylic acid 4-methoxybenzylamide
  参考文献：
  名称：

  Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei

  摘要：

  Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei. The development of novel antitrypanosomal agents is urgently needed. Here we report the synthesis and structure-activity relationship of a new class of benzoxaboroles as antitrypanosomal agents. These compounds showed antiparasitic IC50 values ranging from 4.02 to 0.03 mu g/mL and satisfactory cytotoxicity profile. Three of the lead compounds were demonstrated to cure the parasitic infection in a murine acute infection model. The structure activity relationship of the pyrrolobenzoxaboroles are also discussed. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.04.079

文献信息

• Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei
  作者：Puhua Wu、Jiong Zhang、Qingqing Meng、Bakela Nare、Robert T. Jacobs、Huchen Zhou

  DOI：10.1016/j.ejmech.2014.04.079

  日期：2014.6

  Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei. The development of novel antitrypanosomal agents is urgently needed. Here we report the synthesis and structure-activity relationship of a new class of benzoxaboroles as antitrypanosomal agents. These compounds showed antiparasitic IC50 values ranging from 4.02 to 0.03 mu g/mL and satisfactory cytotoxicity profile. Three of the lead compounds were demonstrated to cure the parasitic infection in a murine acute infection model. The structure activity relationship of the pyrrolobenzoxaboroles are also discussed. (C) 2014 Elsevier Masson SAS. All rights reserved.